Effect of a home-based inspiratory muscular training programme on functional capacity in patients with chronic COVID-19 after a hospital discharge: protocol for a randomised control trial (InsCOVID trial)퇴원 후 만성 COVID-19 환자의 기능 능력에 대한 가정 기반 흡기 근육 훈련 프로그램의 효과: 무작위 대조 시험 프로토콜(InsCOVID 시험)Article Published on 2022-07-012022-09-11 Journal: BMJ Open Respiratory Research [Category] 임상, [키워드] 1:1 acute respiratory syndrome acute respiratory syndrome coronavirus Admission analysis of variance approved baseline blinded coronavirus COVID-19 COVID-19 patients Declaration of Helsinki discharged Effect eight eligible patient enrolled Ethics evaluate exercise exercise intolerance fatigue finding functional functional capacity groups Helsinki hospital Hospital admission hospital discharge IMPROVE inspiratory muscle Intervention muscles muscular National outcome Patient peer-reviewed Pneumonia primary endpoint protocol pulmonary rehabilitation randomised randomised controlled trial receive registration number Regulation Research Research Ethics Research Ethics Committee respiratory muscles Supervised exercise Symptom symptomatic Symptoms the primary endpoint Trial usual care usual care alone variance [DOI] 10.1136/bmjresp-2022-001255 PMC 바로가기 [Article Type] Article
A telerehabilitation programme in post-discharge COVID-19 patients (TERECO): a randomised controlled trialRandomized Controlled Trial Published on 2022-07-012022-10-05 Journal: Thorax [Category] 임상, [키워드] 1:1 95% CI aerobic Block randomisation China COVID-19 COVID-19 patient demonstrated Dyspnoea Effect Exercise capacity Follow-up form greater hospital hospitalised increase Jiangsu lower limb muscle Lung function maximum voluntary ventilation outcome physical Pulmonary function pulmonary rehabilitation Quality of life randomised randomised controlled trial rehabilitation secondary survivor Thoracic treatment effect Trial walking distance were assessed [DOI] 10.1136/thoraxjnl-2021-217382 PMC 바로가기 [Article Type] Randomized Controlled Trial
Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trialRandomized Controlled Trial Published on 2022-06-302022-10-04 Journal: The British Journal of General Practice [Category] COVID19(2023년), SARS, 임상, [키워드] Adaptive platform trial Admission analysed Bayesian models benefit co-primary endpoint Colchicine colchicine group Community Comorbidity Complication COVID-19 COVID-19-related admission CrI criterion death determine hazard ratio Health higher risk hospital IMPROVE median time multi-arm multicentre Odds ratio Open-label other treatment participant positive primary analysis Primary Health Care Probability Prospective randomised randomised controlled trial reduce SARS-CoV-2 Shortness of breath time Time to recovery Treatment Trial usual care with COVID-19 [DOI] 10.3399/BJGP.2022.0083 PMC 바로가기 [Article Type] Randomized Controlled Trial
Prophylaxis in healthcare workers during a pandemic: a model for a multi-centre international randomised controlled trial using Bayesian analysesRandomized Controlled Trial Published on 2022-06-272022-10-05 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] acid acquisition acute respiratory syndrome adaptive Admission Analysis Bayesian Bayesian analysis Bayesian method coronavirus Coronavirus disease 2019 COVID-19 COVID-19 case determine Effect effective Efficacy expected fixed Follow-up futility greater had no hazard ratio HCQ HCW healthcare worker hospitalisation Hydroxychloroquine imperative Infection intensive care International Intervention Ireland less log mechanical ventilation Mortality multicentre New occur occurred Open-label outcome pandemic Pandemics parallel-group participant Pathogens posterior probability Pragmatic primary endpoint proceed Prophylactic Prophylaxis randomised randomised controlled trial RCT recruitment reducing reduction in risk Sample size SARS-CoV-2 SARS-COV-2 infection secondary shown Stopping Treatment Trial Trial registration variable [DOI] 10.1186/s13063-022-06402-w PMC 바로가기 [Article Type] Randomized Controlled Trial
A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes Research Published on 2022-06-242022-10-05 Journal: Nature Communications [Category] 임상, 진단, [키워드] agonist Analysis baseline blood glucose China Chinese patient clinically Cohort cohorts conducted decreased appetite develop diarrhoea effective Efficacy effort eight enrolled evaluate Glucose Haemoglobin investigator involved MOST nausea nine obesity Open-label outcome Patient patients Placebo placebo-controlled plasma randomised randomised controlled trial receive receiving receptor reduced reductions in safety profile secondary subcutaneously T2D Tolerability Tolerance treat Treatment treatment-emergent adverse event type 2 diabete [DOI] 10.1038/s41467-022-31328-x [Article Type] Research
Virtual reality as a teaching method for resuscitation training in undergraduate first year medical students during COVID-19 pandemic: a randomised controlled trialRandomized Controlled Trial Published on 2022-06-222022-10-05 Journal: BMC Medical Education [Category] 임상, [키워드] analysed basic Basic Life Support benefit chain Chain of survival clinical examination Combination computer-generated control group COVID-19 COVID-19 pandemic CsA double-blinded effective Effectiveness enrolled improvement Improvement of procedural skills Intervention intervention group learning Learning gain life mean difference outcome primary endpoint randomised randomised controlled trial reduced reported Research secondary outcome significantly two group virtual reality [DOI] 10.1186/s12909-022-03533-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Experimental pre-tests of public health communications on the COVID-19 vaccine: A null finding for medical endorsement, risk and altruismRandomized Controlled Trial Published on 2022-06-152022-10-05 Journal: Vaccine [Category] COVID19(2023년), SARS, 임상, [키워드] assigned Behavioural Science benefit communication Control COVID-19 COVID-19 vaccine effective eight Government Guidance Health policy hospital information Intention Intervention less no effect outcome participant positive Poster PROTECT Public public health public health communication randomised controlled trial Randomly reaction Research risk risk of COVID-19 Risk perception tested the vaccine vaccination Vaccine hesitancy Vaccine Intention. [DOI] 10.1016/j.vaccine.2022.05.029 PMC 바로가기 [Article Type] Randomized Controlled Trial
Baricitinib in hospitalised patients with COVID-19: A meta-analysis of randomised controlled trialsResearch article Published on 2022-06-032022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 28-day mortality 95% CI Analysis Anti-inflammatory Anti-viral Baricitinib COVID COVID19 database death Dexamethasone discharge disease duration of hospitalisation ECMO Efficacy finding funding hospitalised patient improved mortality IMV inhibitor Invasive mechanical ventilation Jak Janus kinase Janus kinase inhibitors Meta-analysis outcome patients patients with COVID-19 performed positive pressure ventilation progression PROSPERO database random-effects model randomised controlled trial RCT reduce mortality reduced Registered Respiratory failure searched severe disease shown Standard of care Standard therapy statistically significant statistically significant reduction Tocilizumab Treatment with COVID-19 [DOI] 10.1016/j.eclinm.2022.101489 [Article Type] Research article
Comparative-effectiveness research of COVID-19 treatment: a rapid scoping reviewCOVID-19 치료의 비교 효과 연구: 신속한 범위 검토Review Published on 2022-06-032022-09-11 Journal: BMJ Open [Category] 임상, 치료제, [키워드] age Antibiotics Antiviral average average age biorxiv/medrxiv Care category Characteristics children clinical clinical trials Community community care conducted controlled trials convalescent plasma COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 treatment death drug enrolled evaluated Evidence Evidence synthesis hospital Hydroxychloroquine Immunosuppressant immunosuppressants inception information knowledge knowledge synthesis mild symptoms Network meta-analysis on children outcome Participants Patient Primary outcome randomised controlled trial Rapid Remdesivir Research Respiratory medicine scoping review steroid Steroids stimulated study duration systematic review systematic reviews therapeutic Therapeutics Therapies Tocilizumab Treatment [DOI] 10.1136/bmjopen-2020-045115 PMC 바로가기 [Article Type] Review
Virtual respiratory therapy delivered through a smartphone app: a mixed-methods randomised usability study스마트폰 앱을 통해 전달되는 가상 호흡 요법: 혼합 방법 무작위 사용성 연구Article Published on 2022-06-012022-09-11 Journal: BMJ Open Respiratory Research [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] affecting arising artefact breath Breath sound chronic condition comparable COPD COPD exacerbations COVID-19 credibility cystic fibrosis detect dimension distance effective Effectiveness Efficiency effort Engagement evaluate exercise feature Features fibrosis Gamification healthy volunteer healthy volunteers improvement Improvements Incentive spirometry include less Look and feel management participant performed persistence Pneumonia postoperative preference proximal pulmonary rehabilitation questionnaire randomised randomised controlled trial Randomised controlled trials reduction in rehabilitation repeated reported Research respiratory infection respiratory therapy SARS-CoV-2 Satisfaction selective spirometry therapy timer Usability [DOI] 10.1136/bmjresp-2022-001221 PMC 바로가기 [Article Type] Article