Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study)Observational Study Published on 2022-01-012022-10-05 Journal: Inflammation research : official journal of the Eu [Category] 임상, [키워드] Accuracy Activation Admission admitted to ICU adult COVID-19 patients Analysis blood sample calprotectin can be used characterized collected COVID-19 COVID-19 patients Critical dysregulated immune response evaluate ICU ICU admission ICU patient independent intensive care unit Intubated Invasive mechanical ventilation involved Laboratory tests multicenter neutrophil neutrophil activation Neutrophil activation. patients predict Primary outcome prospective observational study Prospective Study reflect required ROC AUC secondary outcome serum severe COVID-19 severe respiratory failure severity significantly higher [DOI] 10.1007/s00011-021-01516-4 PMC 바로가기 [Article Type] Observational Study
Two-dose ChAdOx1 nCoV-19 vaccine protection against COVID-19 hospital admissions and deaths over time: a retrospective, population-based cohort study in Scotland and Brazil시간 경과에 따른 COVID-19 입원 및 사망에 대한 2회 접종 ChAdOx1 nCoV-19 백신 보호: 스코틀랜드와 브라질의 인구 기반 코호트 후향 연구Articles Published on 2022-01-012022-09-10 Journal: Lancet (London, England) [Category] Fulltext, SARS, 변종, [키워드] (Medical Research Council) 95% CI 95% CIs Abstract Acute respiratory infection Analysis association Booster vaccine Brazil Carlos Chaga Carlos Chagas ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 against ChAdOx1 nCoV-19 vaccine challenge Cohort cohort study cohorts COVID-19 COVID-19 vaccine database dataset death defined dominant dose Effectiveness estimate rate ratio estimate rate ratios Fazer finding Follow-up funding Health Data Research UK Hospital admission Hospital admissions Industrial Innovation investigated Laboratory testing material Medical Research Council mortality data National new SARS-CoV-2 outcome pattern Poisson regression population-based cohort rate ratios reflect report respiratory respiratory infection retrospective Rio de Janeiro risk RRs Scottish second dose severe COVID-19 Strategy Suspected translation vaccination Vaccine vaccine dose was used [DOI] 10.1016/S0140-6736(21)02754-9 PMC 바로가기 [Article Type] Articles
Correlation of population mortality of COVID-19 and testing coverage: a comparison among 36 OECD countriesCOVID-19의 인구 사망률과 검사 범위의 상관관계: OECD 36개국 비교Short Paper Published on 2021-12-282022-09-12 Journal: Epidemiology and Infection [Category] MERS, SARS, 진단, [키워드] available data benefit calculated correlated country Coverage COVID-19 COVID-19 pandemic Critical death development disease Fatality rate generate identify infection control Metrics Mortality organization outcome outcomes proportion reflect SARS-CoV-2 Scatter plot sensitive indicator sensitivity Spearman correlation coefficient Taiwan testing coverage threshold were used [DOI] 10.1017/S0950268820003076 PMC 바로가기 [Article Type] Short Paper
Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations신장 오르가노이드 및 임상 인구에서 SARS-CoV-2 반응의 교차 검증Research Article Published on 2021-12-222022-09-10 Journal: JCI Insight [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] Alpha ameliorated Apoptosis Beta blocked Cell cell types Clinical data comparable COVID-19 Critical Critically ill Critically ill patient critically ill patients Cross-validation feature gene expression pattern gene expression patterns Genetic diseases infect Infection interferon interferon pathway iPS cells Kidney disease kidney infection kidney organoid kidneys mechanism Molecular pathology morphology Nephrology organ Organoid organoids peptides polycystic kidney polycystic kidney disease Population populations proteomic proximal proximal tubules reflect reflected replicating virus response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral susceptibility target organs Therapeutics Therapies Treatment tropism upregulation Urine variant Viral viral fitness [DOI] 10.1172/jci.insight.154882 PMC 바로가기 [Article Type] Research Article
Identification of transcriptional regulatory network associated with response of host epithelial cells to SARS-CoV-2SARS-COV-2에 대한 숙주 상피 세포의 반응과 관련된 전사 조절 네트워크의 확인Article Published on 2021-12-142022-09-10 Journal: Scientific Reports [Category] SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] addition analyses approach BTK change Combination complications of COVID-19 Computational biology and bioinformatics computational tool contribute COVID-19 disease epithelial cell epithelial cells exacerbate Gene Expression Gene regulatory networks Host host cell host cells identification identify Immunity Infection Inflammation involved kinase kinases MAPK14 mechanism mitigate organ damage other respiratory virus Other respiratory viruses pathway Pathways provide reflect Regulation Regulatory regulatory network respiratory SARS-CoV-2 Signaling Systems biology therapeutic target transcriptional virus viruses [DOI] 10.1038/s41598-021-03309-5 PMC 바로가기 [Article Type] Article
Immunogenicity after Second ChAdOx1 nCoV-19 (AZD1222) Vaccination According to the Individual Reactogenicity, Health Status and LifestyleArticle Published on 2021-12-132022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acquisition adverse effect age antibody assays AZD1222 blood sample BMI body mass cellular Cellular immune response cellular immunity ChAdOx1 nCoV-19 chill collected correlated correlation creatinine ELISA female had no Health Health status humoral Humoral immunity identify IgG Immunity immunogenicity individual intensity investigated muscle mass neutralizing antibody Questionnaires Rash reactogenicity reflect response SARS-CoV-2 SARS-CoV-2 neutralizing antibody second second dose Sex Side effects status vaccination Vaccine Vaccines virus neutralization test were used [DOI] 10.3390/vaccines9121473 PMC 바로가기 [Article Type] Article
The Pandemic, Infodemic, and People’s Resilience in India: ViewpointViewpoint Published on 2021-12-082022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, SARS, [키워드] acute respiratory syndrome affected build Care caused chronic conditions confirmed COVID-19 case coronavirus country COVID-19 COVID-19 case COVID-19 pandemic COVID-19 vaccination death develop Digital health dissolve driving effort greater Health highlight hospital implementation India Infodemics measure mitigate oxygen cylinder pandemic Patient preventive measure Promoting reflect remote monitoring reported required research finding Resilience SARS-CoV-2 SDGs Stress Support sustainable development goal Sustainable Development Goals wearable technology widespread [DOI] 10.2196/31645 PMC 바로가기 [Article Type] Viewpoint
Physiology labs during a pandemic: What did we learn?A Personal View Published on 2021-12-012022-10-28 Journal: Advances in physiology education [Category] Coronavirus, SARS, [키워드] approach Course COVID-19 COVID-19 pandemic effort facilitate Features information lab Laboratory online learning Physiology physiology laboratory promote reflect remote instruction respond scientific teaching Support transitioned [DOI] 10.1152/advan.00022.2021 PMC 바로가기 [Article Type] A Personal View
Soluble ST2 concentrations associate with in-hospital mortality and need for mechanical ventilation in unselected patients with COVID-19가용성 ST2 농도는 COVID-19로 선택되지 않은 환자의 병원 내 사망률 및 기계적 환기의 필요성과 관련이 있습니다.Observational Study Published on 2021-12-012022-09-11 Journal: Open Heart [Category] SARS, 바이오마커, 임상, [키워드] association baseline Biobank Biomarker Biomarkers cardiovascular disease Chronic kidney disease collected Comparisons Concentration COVID-19 demonstrated determine diabetes disease severity elevated Endothelial dysfunction enrolled fibrosis heart failure hospitalisation hospitalised patient Hospitalised patients hypertension hypoxaemia ICU ICU treatment In-hospital In-hospital death in-hospital mortality independent independent of Inflammation Inflammatory intensive care intensive care unit IQR Kidney disease lower oxygen saturation lung Lungs Male sex mechanical ventilation median Myocardial myocardial fibrosis non-survivor Non-survivors Older age outcome outcomes oxygen pathophysiological pathophysiology patients died patients with COVID-19 produced reflect registration number respiratory rate Risk factors robust SARS-CoV-2 smoking ST2 survivor thrombosis Treatment Viraemia with COVID-19 [DOI] 10.1136/openhrt-2021-001884 PMC 바로가기 [Article Type] Observational Study
Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging studyResearch article Published on 2021-12-012022-10-05 Journal: Brain, Behavior, & Immunity - Health [Category] 바이오마커, [키워드] acute COVID-19 Anxiety approach association Brain Brain imaging clearance contribute correlated COVID COVID-19 Depression depressive Diffusion-tensor imaging disease distress functional Functional connectivity Grey matter Hypothesis immune response Inflammation Inflammatory biomarker insular cortex lesions magnetic resonance imaging measure medical illness MRI neutrophil overlapping peripheral lymphocyte Perspective Platelet post-traumatic predicted PTSD reflect Resting state SARS-CoV-2 severity SII Support survivor Survivors syndrome systemic systemic inflammation virus Volume White matter widespread with COVID-19 [DOI] 10.1016/j.bbih.2021.100387 [Article Type] Research article