Associations Between the Use of Renin–Angiotensin System Inhibitors and the Risks of Severe COVID-19 and Mortality in COVID-19 Patients With Hypertension: A Meta-Analysis of Observational StudiesCardiovascular Medicine Published on 2021-04-262022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 95% CI 95% confidence interval ACEi ACEIs acute respiratory syndrome all-cause mortality Angiotensin converting enzyme inhibitors angiotensin receptor blocker Angiotensin receptor blockers angiotensin-converting enzyme 2 appear ARB ARBs articles association Cochrane Library coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients death disease severity drug duration of hospitalization eligible entry of SARS-CoV-2 enzyme host cells hypertension inhibitor mean difference Meta-analysis Mortality no significant difference observational study participant patients with COVID-19 receptor reduction in remains uncertain risk SARS-CoV-2 Seven severe COVID-19 severe disease significant effect significantly Support System target receptor Treatment two group upregulation was performed [DOI] 10.3389/fcvm.2021.609857 PMC 바로가기 [Article Type] Cardiovascular Medicine
Transmission of SARS-CoV-2 before and after symptom onset: impact of nonpharmaceutical interventions in ChinaCovid-19 Published on 2021-04-212022-10-31 Journal: European Journal of Epidemiology [Category] COVID-19, MERS, SARS, [키워드] Asymptomatic baseline China Contact tracing COVID-19 Effect effective Frequency indicate Infection Intervention Isolation less limit nonpharmaceutical intervention Nonpharmaceutical interventions NPI observation population level post-symptom onset presymptomatic presymptomatic transmission quarantine reduce reduced reducing reduction in reductions in remains uncertain SARS-CoV-2 Spread Stage supplementary material Symptom symptom onset Transmission was reduced [DOI] 10.1007/s10654-021-00746-4 PMC 바로가기 [Article Type] Covid-19
Effect of Information about COVID-19 Vaccine Effectiveness and Side Effects on Behavioural Intentions: Two Online ExperimentsArticle Published on 2021-04-132022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] addressed benefit clinical trials communication COVID-19 COVID-19 vaccination COVID-19 vaccines Effect Effectiveness Efficacy engage Evidence Hesitancy highlighting Immunity information Intention limitation maintain not reduce offer participant protective behaviour public health measure receive reduce remains uncertain side Side effects significantly social distancing Transmission vaccinated individual vaccination Vaccine vaccine messaging Vaccines virus widespread [DOI] 10.3390/vaccines9040379 PMC 바로가기 [Article Type] Article
Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational studyObservational Study Published on 2021-03-192022-10-04 Journal: Critical Care [Category] 임상, [키워드] acute respiratory distress adopted adult COVID-19 patient age analyzed approved ARDS Arterial blood ga Brain Carbon dioxide removal cerebral Cerebral oxygenation change conducted coronavirus correlated correlation COVID-19 patient COVID-19 patients Critically ill Effect Effectiveness Efficacy evaluate Inhaled Italy Liguria lung male mechanically ventilated median nitric oxide oxygen oxygen saturation Oxygenation PaO pathophysiological mechanisms patients performed Prone position prone positioning prospective observational study protocol recruitment Recruitment maneuvers reduction Registration remains uncertain rescue Rescue therapies Result resulting significant increase significantly Study protocol supplementary material syndrome Therapies therapy ventilatory [DOI] 10.1186/s13054-021-03537-1 PMC 바로가기 [Article Type] Observational Study
Determination of the Concentration of IgG against the Spike Receptor-Binding Domain That Predicts the Viral Neutralizing Activity of Convalescent Plasma and Serum against SARS-CoV-2Article Published on 2021-03-102022-10-28 Journal: Biology [Category] COVID-19, [키워드] activity Anti-RBD IgG antibody B-cell Cohort Concentration convalescent convalescent patient convalescent plasma coronavirus coronavirus disease correlated COVID-19 COVID-19 convalescent patient death detection system Determination diagnosed disease severity Donor donors Efficacy ELISA ELISA test Gender Health help Hyperimmune plasma IgG IgG antibody immunization in vitro independent induce Infection large cohort Neutralizing Neutralizing activity passive immunization Patient patients with COVID-19 plasma plasma concentration predict Prevent Quantitative RBD RBD IgG remains uncertain responses SARS-CoV-2 SARS-COV-2 infection serum significantly simple spike receptor-binding domain the Spike therapeutic treatment for COVID-19 virus [DOI] 10.3390/biology10030208 PMC 바로가기 [Article Type] Article
Quantifying asymptomatic infection and transmission of COVID-19 in New York City using observed cases, serology, and testing capacity430 Published on 2021-03-022022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] acute respiratory syndrome aggregate assumed assumption Asymptomatic Asymptomatic case asymptomatic infection asymptomatic transmission average basic reproductive number changes in community transmission contribute coronavirus COVID-19 determine develop Epidemic epidemiological Epidemiological model epidemiological parameter estimates estimate faster force of infection generates Health Immunity include infected case Infection information Intervention New York City outbreak presymptomatic proportion recent reduce remains uncertain reproductive required Secondary infection serology Significance Spread structures subpopulation Surveillance symptomatic symptomatic and asymptomatic symptomatic case symptomatic infections Symptoms testing submodel the epidemic Transmissibility Transmission [DOI] 10.1073/pnas.2019716118 PMC 바로가기 [Article Type] 430
Distinct pattern of microsusceptibility changes on brain magnetic resonance imaging (MRI) in critically ill patients on mechanical ventilation/oxygenationDiagnostic Neuroradiology Published on 2021-03-012022-10-29 Journal: Neuroradiology [Category] COVID-19, MERS, SARS, [키워드] abnormality affected association Brain callosum change changes in conducted corpus Critically ill patient described ECMO etiology extracorporeal membrane oxygenation Extracorporeal membrane oxygenation (ECMO) FIVE foci Hypoxemia ICU ICU patient Infection intensive care unit magnetic resonance imaging Magnetic resonance imaging (MRI) mechanical ventilation median age Microbleeds MRI Neurological complication nuclei over Patient patients remains uncertain Respiratory failure Result Retrospective study subcortical susceptibility was performed [DOI] 10.1007/s00234-021-02663-5 PMC 바로가기 [Article Type] Diagnostic Neuroradiology
Potential Mechanisms of Cardiac Injury and Common Pathways of Inflammation in Patients With COVID-19COVID-19 환자의 심장 손상 및 일반적인 염증 경로의 잠재적 기전Review Published on 2021-03-012022-09-11 Journal: Critical pathways in cardiology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute infectious disease Acute myocarditis acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor Apoptosis association autopsy studies binding affinity biologic Biomarker Biomarkers C-reactive protein cardiac cardiac injury cardiovascular complication cardiovascular complications Clinical studies clinical study common controlled clinical studies coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine secretion demonstrated despair disease pathogenesis effort Epidemic Genetic genetic recombination High-sensitivity C-reactive protein higher risk histopathological hypoxia in-hospital mortality Inflammation Injury lack lethal disease linear correlation management mechanism morbidity and mortality Myocardial myocarditis other coronaviruses outbreak Outbreaks pandemic Pathogenesis Patient patients hospitalized plasma poor prognosis positive linear correlation Potential potential mechanism Protein Randomized Receptor binding Recombination remains uncertain reported Research risk factor Risk factors significantly spike Spike protein Strong systemic inflammation the disease therapeutic tissue damage Treatment troponin T virus virus spike protein with COVID-19 [DOI] 10.1097/HPC.0000000000000227 PMC 바로가기 [Article Type] Review
The Effect of IL-6 Inhibitors on Mortality Among Hospitalized COVID-19 Patients: A Multicenter Study입원한 COVID-19 환자의 사망률에 대한 IL-6 억제제의 영향: 다기관 연구Multicenter Study Published on 2021-02-242022-09-12 Journal: The Journal of Infectious Diseases [Category] MERS, 진단, [키워드] 95% confidence interval acute respiratory syndrome adjusted analyzed average Comorbidities Comorbidity confidence interval confounder coronavirus coronavirus disease COVID-19 cytokine release Cytokine release syndrome demographics disease severity Effect effect size Effectiveness estimate hospital IL-6 in-hospital mortality inhibitor inhibitors interleukin 6 inhibitors. interleukin-6 Logistic multicenter study Odds ratio Patient patients polymerase chain Population positive Precision Probability reducing reduction in regions remains uncertain sensitivity analysis suggested Treatment Weighting [DOI] 10.1093/infdis/jiaa717 PMC 바로가기 [Article Type] Multicenter Study
The impact of COVID-19 pandemic outbreak on education and mental health of Chinese children aged 7–15 years: an online surveyResearch Article Published on 2021-02-242022-10-28 Journal: BMC Pediatrics [Category] COVID-19, MERS, [키워드] affecting Analysis authority caused children China Chinese COVID-19 COVID-19 epidemic COVID-19 pandemic Depression depressive symptom Depressive symptoms Effect effective effective intervention Effectiveness evaluate Factor FIVE knowledge media mental health multiple logistic regression online education outbreak parent Post-traumatic stress disorder proportion Psychological psychological problem PTSD question questionnaire Region remains uncertain Research Result significantly significantly higher Symptom Symptoms triggered WeChat [DOI] 10.1186/s12887-021-02550-1 PMC 바로가기 [Article Type] Research Article