Effect of COVID-19 medications on corrected QT interval and induction of torsade de pointes: Results of a multicenter national survey교정 QT 간격 및 Torsade de Pointes 유도에 대한 COVID-19 약물의 영향: 다기관 국가 조사 결과Multicenter Study Published on 2021-07-012022-09-11 Journal: International journal of clinical practice [Category] SARS, 치료제, [키워드] addressed administration Amiodarone arrhythmia Atazanavir Azithromycin Chloroquine Cohort Combination combination therapy coronavirus coronavirus disease COVID-19 COVID-19 patient Critical death demonstrated during treatment Effect Favipiravir female gender furosemide heart failure hepatic dysfunction hospital hospitalised Hydroxychloroquine hypokalaemia incidence inclusion criteria Iran life-threatening Lopinavir Lopinavir-ritonavir Lopinavir/ritonavir medication medications multicenter National occurred oseltamivir Patient patients predicted Primary outcome Prospective Study QT interval QT prolongation QTc QTC prolongation Remdesivir renal reported Repurposed drug Repurposed drugs Result risk Ritonavir secondary outcome Secondary outcomes Side effect therapy Torsade de Pointes treated Treatment [DOI] 10.1111/ijcp.14182 PMC 바로가기 [Article Type] Multicenter Study
A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase뉴클레오사이드 유사체와 SARS-CoV-2 RNA 의존성 RNA 중합효소의 상호작용에 대한 고찰Review Published on 2021-06-302022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] Antiviral antiviral drugs approved clinical development computational analysis CoV COVID-19 CoVs drug Efficacy ExoN ExoN proofreading Favipiravir human CoV human CoVs Infection information inhibitor Interaction lack nucleoside nucleoside analogue Nucleoside analogues outbreak platform preserved RdRP Remdesivir Repurposed drug ribavirin RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 sofosbuvir tenofovir Vaccine [DOI] 10.1016/j.ijbiomac.2021.03.112 PMC 바로가기 [Article Type] Review
Does Covera-19 know ‘when to hold ‘em or ‘when to fold ‘em? A translational thought experimentReview Published on 2021-06-302022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] Acidic amino acid sequence change changes conformational change COVID-19 Effect electrical experiment Extracellular function furin histidine Host human host induce Protein receptor Repurposed drug Research SARS-CoV-2 survival thought translational Treatment [DOI] 10.1186/s41231-021-00090-5 PMC 바로가기 [Article Type] Review
Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics SimulationsTMPRSS2 프로테아제와 Leupeptin의 강력한 결합은 SARS-CoV-2 용도 변경 약물에 대해 Camostat 및 Nafamostat의 대안이 될 수 있습니다: 분자 도킹 및 분자 역학 시뮬레이션에서 평가Article Published on 2021-06-012022-08-31 Journal: Applied biochemistry and biotechnology [Category] MERS, SARS, 신약개발, 치료제, [키워드] Acute respiratory infection Amino acid amino acids bind binding binding affinity camostat Camostat mesylate caused clinical trial Complete complete cure coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 disease docking study drug drug target drugs Dynamics evaluate form Host human cell humans Infection information inhibit inhibiting Interaction key amino acid key amino acids less leupeptin life MD simulation MD simulations molecular molecular docking molecular dynamics nafamostat outbreak performed protease reported Repurposed drug Repurposed drugs respiratory respiratory infection reveal RMSD RMSF SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection Serine serine 2 Simulation stability Strong tested the SARS-CoV-2 virus TMPRSS2 TMPRSS2 protein transmembrane transmembrane protease serine 2 virus entry virus infection Wuhan Wuhan, China [DOI] 10.1007/s12010-020-03475-8 PMC 바로가기 [Article Type] Article
Chemoprophylaxis trial designs in epidemics: insights from a systematic review of COVID-19 study registrations전염병에 대한 화학 예방 실험 설계: COVID-19 연구 등록에 대한 체계적인 검토에서 얻은 통찰력Review Published on 2021-05-292022-09-10 Journal: Trials [Category] SARS, 변종, 치료기술, 치료제, [키워드] adaptive adaptive design Adaptive platform trial Adults alignment Analysis attack rate attack rates Care Chain Reaction Chemoprophylaxis Chloroquine clinically collaboration component control group coronavirus country COVID-19 COVID-19 vaccines database detect effect size effective Efficacy Efficacy and safety eligibility enrolment Epidemic Epidemics epidemiologically Evidence evidence of exit feasible feature focus followed by General population generate healthcare worker Healthcare workers Hydroxychloroquine implementation Infection Infectious disease Infectious diseases information International IQR less Long-term care Lopinavir Lopinavir/ritonavir mechanism median median size novel vaccines offer Older older adult Older adults pandemic patients polymerase chain reaction Polymerase chain reaction testing PrEP Primary outcome Prophylaxis protocol provided public health randomised Rapid recruitment Registered Repurposed drug Repurposed drugs required Result review Ritonavir robust safety analysis SARS-CoV-2 screened searched Serological testing study population supplementary material Supporting systematic review target population Trial trial infrastructure Trial registration trials utility Vaccine Vaccines virus variants was used were assessed widespread without symptom [DOI] 10.1186/s13063-021-05323-4 PMC 바로가기 [Article Type] Review
Clinical Management of COVID-19: A Review of Pharmacological Treatment OptionsReview Published on 2021-05-282022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] administration of corticosteroid antivirals applied approval approved casirivimab/imdevimab Chloroquine clinical clinical experience Clinical management clinical study conducted convalescent plasma COVID-19 COVID-19 pandemic COVID-19 therapeutics curtail disease drug drugs Effect Efficacy Efficacy and safety effort Emergency evaluated Evidence Favipiravir FDA global pandemic global scientific community Google Scholar Hydroxychloroquine immunoglobulins interferons intravenous lack management Molecular biology off-label option outbreak pathophysiology pharmacological agent public health reduce REGN-CoV2 Remdesivir Repurposed drug review risk SARS-CoV-2 Scientific community shown Spread standard treatment subsequent the disease therapeutic therapy tissue plasminogen activator Tocilizumab Treatment umifenovir Vaccine Volume while [DOI] 10.3390/ph14060520 PMC 바로가기 [Article Type] Review
Medication of Hydroxychloroquine, Remdesivir and Convalescent Plasma during the COVID-19 Pandemic in Germany—An Ethical AnalysisArticle Published on 2021-05-262022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Affect Analysis analyzed assist Clinical ethics clinical setting clinical study conditions convalescent plasma COVID-19 COVID-19 pandemic disease outbreak distribution drug early stage Effect Epidemic ethical guideline excluded expand facilitate Germany group groups inclusion criteria maintain Medicine off-label pandemic Patient Perspective pharmaceutical preparations public health reaction reduce Remdesivir Repurposed drug SARS-CoV-2 Treatment use of hydroxychloroquine [DOI] 10.3390/ijerph18115685 PMC 바로가기 [Article Type] Article
Biomedical Text Link Prediction for Drug Discovery: A Case Study with COVID-19Article Published on 2021-05-262022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome Algorithm Anti-inflammatory antiviral therapy Artemisinin Biotin Bone marrow calculated Chloroquine complement complex Complex networks coronavirus Coronaviruses COVID-19 data sets Diseases drug drug candidate Drug discovery Efficacy envelope proteins heterogeneous identify include inhibitors interferon knowledge leukocyte literature review machine learning MERS methotrexate natural language processing nucleoside analogs occur outbreak predict predicted prediction protease inhibitors Proteins Repurposed drug Repurposed drugs SARS Coronavirus SARS-CoV-2 SARS-CoV-2 treatment Side effects Suramin syndrome text text mining Therapies treat vaccination with COVID-19 [DOI] 10.3390/pharmaceutics13060794 PMC 바로가기 [Article Type] Article
Prediction of repurposed drugs for Coronaviruses using artificial intelligence and machine learningResearch Article Published on 2021-05-242022-10-04 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, [키워드] Abstract ACE AI Alatrofloxacin Algorithm analyses antiviral drug antiviral drugs applicability approved artificial assist binding affinity caused Chemical descriptors complex computational method coronavirus coronavirus 2 Coronaviruses COVID-19 COVID-19 pandemic datasets deep develop domain drug candidate Drug repurposing DrugBank Epidemics feature filtered forest independent lack learning Leuprolide machine learning MERS Metergoline molecular docking network Neural Pearson’s correlation coefficient predict predicted molecule prediction Predictive model receptor Repository Repurposed drug Rescinnamine respiratory responsible robust SARS-CoV-2 selected support vector machine Telotristat ethyl the Coronaviridae the spike protein unique Verteporfin virus viruses were used [DOI] 10.1016/j.csbj.2021.05.037 PMC 바로가기 [Article Type] Research Article
Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study코로나19 환자의 용도 변경 및 보조제 사용: 다국적 네트워크 코호트 연구Research Published on 2021-05-112022-09-10 Journal: The BMJ [Category] Fulltext, SARS, 신약개발, [키워드] antagonists Antibiotics Azithromycin benefit ceftriaxone China cohort study common Corticosteroid Corticosteroids COVID-19 pandemic declined Dexamethasone drug Electronic health record Electronic health records enoxaparin FIVE H2 receptor hospital Hospital admission Hydroxychloroquine in hospital patient Lopinavir LOPINAVIR AND RITONAVIR Lopinavir-ritonavir management Multiple objective outcome measure pandemic participant Patient prescription Prescriptions receptor antagonists remained Repurposed drug Repurposed drugs Result risk Ritonavir setting South Korea Spain The United States Treatment umifenovir United States Variation Vitamin D were used [DOI] 10.1136/bmj.n1038 PMC 바로가기 [Article Type] Research