A computational and bioinformatic analysis of ACE2: an elucidation of its dual role in COVID-19 pathology and finding its associated partners as potential therapeutic targetsACE2의 컴퓨터 및 생물정보학 분석: COVID-19 병리학에서 ACE2의 이중 역할에 대한 설명 및 잠재적인 치료 표적으로서 관련 파트너 찾기Article Published on 2022-03-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acting acute respiratory distress acute respiratory distress syndrome Acute respiratory distress syndrome Predicted ACE2 structure Analysis analyzed angiotensin Angiotensin-converting enzyme Angiotensin-converting enzyme -2 angiotensin-converting enzyme 2 ARDS bioinformatic analysis CDS Cell coding COVID-19 pandemic COVID-19 pathology determine Differentially expressed genes disease distress DNA sequence downregulation effort enzyme FOS FOXO4 FOXP2 healthy human lung tissue involved list low expression mechanism MiR-212-5p miRNA miRNA target miRNA targets miRNA-1246. pandemic pathological changes potential therapeutic target provide receptor respiratory distress Respiratory distress syndrome Spike protein Spread syndrome transcription factor transcription factors upregulation Vaccine viral entry viral spike protein [DOI] 10.1080/07391102.2020.1833760 PMC 바로가기 [Article Type] Article
Tocilizumab treatment in severe COVID-19: a multicenter retrospective study with matched controls중증 COVID-19에서의 토실리주맙 치료: 대조 대조군을 사용한 다기관 후향적 연구Multicenter Study Published on 2022-03-012022-09-11 Journal: Rheumatology International [Category] 진단, 치료제, [키워드] Activation acute respiratory distress acute respiratory distress syndrome Analysis anti-IL-6R approach ARDS Arm ARMS carried case-control study collected Control coronavirus coronavirus disease COVID-19 criteria Critical cytokine Cytokine storm death develop distress effective Efficacy evaluate feature ferritin Gender hospitalized COVID-19 patients IL-6 in some interleukin interleukin-6 Interleukin-6 (IL-6) intubation logistic regression models Macrophage macrophage activation syndrome multicenter Multiple no significant difference outcome parameters Patient patients Pneumonia Primary outcome procalcitonin progression provided reduced reduction in Regression model reported respiratory distress Respiratory distress syndrome retrospective retrospective cohort Retrospective study SAS severe disease shown significantly Standard of care study population subset syndrome Tocilizumab Treatment was reduced was used [DOI] 10.1007/s00296-021-04965-6 PMC 바로가기 [Article Type] Multicenter Study
Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19심각한 COVID-19의 폐포, 내피 및 장기 손상 마커 역학Observational Study Published on 2022-03-012022-09-11 Journal: American Journal of Respiratory and Critical Care [Category] MERS, SARS, 바이오마커, 임상, [키워드] 95% CI 95% confidence interval alveolar alveolar epithelial cells alveolar injury angiopoietin angiotensin association Biomarker Biomarkers calculated cardiac change changes in contribute coronavirus coronavirus disease COVID-19 COVID-19 severity Day Disease progression distress Dynamics emergency department endothelial endothelial injury endothelial marker Endothelial markers Endothelium enrolled epithelial epithelial cells Health Organization Injury intubated patients invasive ventilation Kidney injury marker measurement multivariable observational study outcome outcomes Patient patients patients with COVID-19 RAGE rationale receptor renal Renin renin-angiotensin system respiratory respiratory distress Respiratory distress syndrome Respiratory Support severe COVID-19 severity significantly single-center syndrome troponin Troponin-I ventilated patient Ventilation ventilatory with COVID-19 World Health Organization [DOI] 10.1164/rccm.202106-1514OC PMC 바로가기 [Article Type] Observational Study
Thrombosis pathways in COVID‐19 vs. influenza‐associated ARDS: A targeted proteomics approachArticle Published on 2022-02-272023-06-14 Journal: Journal of thrombosis and haemostasis : JTH [Category] COVID19(2023년), MERS, SARS, [키워드] COVID‐19 Influenza Pulmonary embolism Respiratory distress syndrome thrombosis [DOI] 10.1111/jth.15671 PMC 바로가기
Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implicationsSARS-CoV-2 ARDS의 프로테아제-항-프로테아제 구획화: 치료적 의미Articles Published on 2022-02-222022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome airway airways Alpha alpha-1 antitrypsin ARDS ARDS patients balance circulation cleavage cleaved detectable down-regulated Effect elevated evaluated finding IL-6 IL-6 level IL-6 receptor implication induction inhibitor interleukin interleukin-6 investigated involved less Level lung lung parenchyma moderate NET neutrophil Neutrophil elastase Neutrophils occurred patients plasma protease Proteins receptor antagonist regulate respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 ARDS SARS-COV-2 infection secretion Standard of care syndrome target therapy tissue Tocilizumab tracheal were measured [DOI] 10.1016/j.ebiom.2022.103894 PMC 바로가기 [Article Type] Articles
High procalcitonin levels associated with increased intensive care unit admission and mortality in patients with a COVID-19 infection in the emergency department응급실에서 COVID-19 감염 환자의 집중 치료실 입원 및 사망률 증가와 관련된 높은 Procalcitonin 수준Research Article Published on 2022-02-212022-09-10 Journal: BMC Infectious Diseases [Category] COVID19(2023년), Fulltext, MERS, SARS, 바이오마커, [키워드] 105 patient 105 patients 95% CI 95% confidence interval acute respiratory distress acute respiratory distress syndrome adjusted Admission age Analysis ARDS assist association AUC Bacterial bacterial coinfections Biomarker Biomarkers C-reactive protein C-reactive protein (CRP calculate center clinical decision Comorbidities Comorbidity Confirmed COVID-19 infection COVID-19 COVID-19 infection COVID-19 infections CRP D-dimer Decision making decision making process defined develop elevated emergency department Erasmus Final final analysis hospital discharge Hospital mortality hyperinflammation ICU ICU admission in-hospital mortality intensive care intensive care unit Logistic regression Mortality multivariable model Netherlands Odds ratio outcome Patient patients with COVID-19 PCT physician Primary outcome procalcitonin procalcitonin level reached required respiratory distress Respiratory distress syndrome Result retrospective cohort study Severe COVID-19 Infection severe COVID-19 infections Sex significantly supplementary material syndrome were measured [DOI] 10.1186/s12879-022-07144-5 PMC 바로가기 [Article Type] Research Article
Silymarin/curcumin loaded albumin nanoparticles coated by chitosan as muco-inhalable delivery system observing anti-inflammatory and anti COVID-19 characterizations in oleic acid triggered lung injury and in vitro COVID-19 experiment키토산으로 코팅된 실리마린/커큐민 로딩 알부민 나노입자는 올레산 유발 폐 손상 및 시험관 내 COVID-19 실험에서 항염증 및 항 COVID-19 특성을 관찰하는 점막 흡입성 전달 시스템Article Published on 2022-02-152022-09-11 Journal: International journal of biological macromolecules [Category] 비임상, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome albumin alveolar Anti-inflammatory anti-viral activity assembly bovine bovine serum albumin BSA C-reactive protein can be used candidate chitosan coated coronavirus COVID-19 edema Efficacy ENhance experiment Health health problem hyaline membrane hyaline membranes hyperplasia identify in vitro infected patient infected patients Inflammation inflammatory process interleukin interleukin-6 Lung injury lung lesion lung lesions moment Mucoadhesive. oleic acid overcome Pneumonia Polymer Protein reduction in respiratory respiratory distress Respiratory distress syndrome septal serum albumin silymarin syndrome treated Treatment treatment of COVID-19 triggered virus [DOI] 10.1016/j.ijbiomac.2021.12.073 PMC 바로가기 [Article Type] Article
Pathophysiology of coronavirus-19 disease acute lung injuryArticle Published on 2022-02-132023-06-15 Journal: Current opinion in critical care [Category] COVID19(2023년), MERS, SARS, [키워드] Coronavirus-19 disease Critical care Physiology respiratory Respiratory distress syndrome SARS-CoV-2 [DOI] 10.1097/MCC.0000000000000911 PMC 바로가기
Galectin-3 as a potential prognostic biomarker of severe COVID-19 in SARS-CoV-2 infected patientsSARS-CoV-2 감염 환자에서 심각한 COVID-19의 잠재적 예후 바이오마커로서의 Galectin-3Observational Study Published on 2022-02-032022-09-10 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 치료기술, [키워드] 95% CI acute respiratory distress acute respiratory distress syndrome Admission Airway inflammation albumin allocation Analysis ARDS binding Biomarker characteristic clinician Combination contributing to correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity CRP Cytokines D-dimer death defined determine discharge Evidence facilitate galectin-3 highest Hyperinflammatory IMV In-hospital death independent Invasive mechanical ventilation Logistic regression analysis marker multi-organ failure multivariable logistic regression Multivariable logistic regression analysis neutrophil neutrophil count neutrophil infiltration NLR Odds ratio outcome outcomes Patient predict Predictive markers pro-inflammatory cytokine pro-inflammatory cytokines prognostic prognostic biomarker receiver operating characteristic resource respiratory distress Respiratory distress syndrome risk ROC RT-PCR SARS-CoV-2 infected patient serum severe COVID-19 significantly syndrome viral infection [DOI] 10.1038/s41598-022-05968-4 PMC 바로가기 [Article Type] Observational Study
Lower Driving Pressure and Neuromuscular Blocker Use Are Associated With Decreased Mortality in Patients With COVID-19 ARDSObservational Study Published on 2022-02-012023-07-07 Journal: Respiratory care [Category] COVID19(2023년), [키워드] COVID-19 Driving pressure mechanical ventilation neuromuscular blockade Respiratory distress syndrome SARS-CoV-2 [DOI] 10.4187/respcare.09577 [Article Type] Observational Study