ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity Research Published on 2021-03-162022-10-05 Journal: Nature Microbiology [Category] SARS, 변종, [키워드] Activation antagonized Antiviral antiviral response caspase caused coronavirus Coronaviruses COVID-19 COVID-19 pandemic domain evade host innate immunity identify IFN response immune evasion Innate immunity interferon ISG15 ISGs MDA5 mechanism Melanoma oligomerization Papain-like protease picornaviruses promote Protein recruitment RIG-I RIG-I-like receptors SARS-CoV-2 the SARS-CoV-2 Trigger upregulating Vaccine Viral RNA viruses [DOI] 10.1038/s41564-021-00884-1 [Article Type] Research
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon ResponseArticle Published on 2021-03-022022-10-06 Journal: Cells [Category] SARS, 진단, [키워드] acute respiratory syndrome antiviral drug antiviral immune response antiviral immunity association characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Gene Expression Host IFN IFN signaling induction Influenza virus inhibited Interaction interferon interferon regulatory factor IRF3 lack modulating molecular motif N protein nonstructural protein 1 nuclear translocation nucleocapsid protein pandemic pathogenesis of SARS-CoV-2 Protein response RIG-I RIG-I like receptors SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein suppressed target TBK1 the SARS-CoV-2 TRIM25 type I urgency Zika virus [DOI] 10.3390/cells10030530 PMC 바로가기 [Article Type] Article
SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocationSARS-CoV-2 nsp12는 IRF3 핵 전위를 억제하여 I형 인터페론 생산을 약화시킵니다Article Published on 2021-02-262022-09-11 Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 변종, 치료제, [키워드] (RdRp) Activation Analysis Antiviral antiviral immunity antiviral responses attenuate COVID-19 dependent on dose-dependent manner global pandemic Host host antiviral responses IFN IFN-β immune evasion impair inducer inhibited inhibiting Innate immunity IRF3 MAVS MDA5 not dependent Nsp12 nuclear translocation overexpression pathogenic Phosphorylation poly(I:C) polymerase promoter provide RdRP respiratory respiratory RNA viruses reveal RIG-I RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp Sendai virus SeV suggested suppresse suppressed triggered type I interferon Viral viral infection viral pathogenesis Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1038/s41423-020-00619-y PMC 바로가기 [Article Type] Article
SARS-CoV-2 Proteins Exploit Host’s Genetic and Epigenetic Mediators for the Annexation of Key Host Signaling PathwaysMolecular Biosciences Published on 2021-01-272022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Aberration Annexation Anomaly antiviral immune response approach autophagy cellular signaling pathway Comorbidities complications COVID-19 COVID-19 patient death deregulated Diabetic differentially expressed disease enrichment analysis Epigenetic epigenetic regulation Factors fatty heart development help helping HIF-1 Host host gene Host immune response host proteins host-virus interactions IL-17 immune evasion immune signaling pathway immune signaling pathways in viral infancy Interaction involved kidney development lung mechanism mediator miRNA modulate pandemic Pathogenesis pathogenic pathophysiology pathway Protein RIG-I SARS-CoV-2 SARS-COV-2 infection Signaling signaling pathway suppressed survival therapeutic intervention toll-like receptor signaling transcription factor understanding Viral protein Viral proteins virus while [DOI] 10.3389/fmolb.2020.598583 PMC 바로가기 [Article Type] Molecular Biosciences
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β ProductionSARS-CoV-2 뉴클레오캡시드 단백질은 RIG-I와 상호작용하고 RIG 매개 IFN-β 생산을 억제합니다Article Published on 2020-12-302022-09-10 Journal: Viruses [Category] MERS, SARS, 치료법, [키워드] ATPase binding cellular clinical Clinical data Coronavirus disease 2019 COVID-19 demonstrated domain downstream highly pathogenic Human IFN IFN-β immunostimulatory Infection initial innate immune interferon interferon beta N protein nucleocapsid pathway Pattern recognition pattern recognition receptor poly(I:C poly(I:C) Production Protein PRR public health represse repressed responsible retinoic acid retinoic acid-inducible gene I RIG-I RNA viruses RNAs SARS-CoV-2 SARS-CoV-2 N protein Sendai virus SeV severe acute respiratory syndrome coronavirus 2 signaling molecule signaling molecules suggested suppresse suppressed the SARS-CoV-2 type I interferon virus infection [DOI] 10.3390/v13010047 PMC 바로가기 [Article Type] Article
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 막(M) 단백질은 RIG-I/MDA-5 신호전달을 표적으로 하여 I형 및 III형 인터페론 생산을 억제합니다Article Published on 2020-12-282022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affected Antiviral antiviral immunity attenuate caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytosolic ectopic expression ENhance evade facilitate IFN Immune suppression individuals Infection Infectious diseases inhibit Innate immunity interact interferon Interpretation IRF3 M protein MAVS mechanism membrane molecular mechanism multiprotein complex nuclear translocation pathogenic pathway Phosphorylation Protein provide Replication reported respiratory RIG-I SARS-CoV-2 SeV severe acute respiratory syndrome Coronavirus Signaling Spread stimulated stomatitis suppresse suppression TBK1 the SARS-CoV-2 TRAF3 type I type I and III IFNs vesicular stomatitis vesicular stomatitis virus Viral viral replication [DOI] 10.1038/s41392-020-00438-7 PMC 바로가기 [Article Type] Article
A role for retinoids in the treatment of COVID-19?Review Published on 2020-10-012023-07-06 Journal: Clinical and experimental pharmacology & physiolog [Category] SARS, [키워드] COVID-19 IFN-I interferons retinoids RIG-I SARS-CoV-2 vitamin A [DOI] 10.1111/1440-1681.13354 [Article Type] Review
β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signalingArticle Published on 2020-09-012023-06-14 Journal: Acta pharmacologica Sinica [Category] Fulltext, 신종인플루엔자, [키워드] acute lung injury Anti-inflammatory IFN-β influenza A virus RIG-I β-sitosterol. [DOI] 10.1038/s41401-020-0403-9 PMC 바로가기
Histone Deacetylase 6 Knockout Mice Exhibit Higher Susceptibility to Influenza A Virus InfectionArticle Published on 2020-07-062023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] CD80 CXCL10 HDAC6 histone deacetylase 6 IAV IL15 influenza A virus knockout mice RIG-I type I interferon [DOI] 10.3390/v12070728 PMC 바로가기 [Article Type] Article
Beyond Anti-viral Effects of Chloroquine/HydroxychloroquineImmunology Published on 2020-07-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 affected anti-inflammatory property anti-viral effect antigen processing Antiviral appear Arthritis Autoimmune diseases autophagy cellular activation Chloroquine country COVID-19 COVID-19 pandemic COVID-19 patients cytosolic decrease detrimental discrepancy Effect Efficacy explain highlight Host immune response Hydroxychloroquine in vitro Inflammation Inflammatory cytokine inflammatory process inhibit interfere interferon limit lysosomal nucleic acids Patient progression receptor remained Replication required RIG-I SARS virus SARS-CoV2 SARS-CoV2 infection secretion Signaling STING therapy TLR Toll-like receptor Treatment type I interferon virus [DOI] 10.3389/fimmu.2020.01409 PMC 바로가기 [Article Type] Immunology