Mutational Hotspot in the SARS-CoV-2 Spike Protein N-Terminal Domain Conferring Immune Escape PotentialSARS-COV-2 스파이크 단백질 N- 말단 도메인 면역 탈출 가능성을 부여하는 돌연변이 핫스팟Article Published on 2021-10-202022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 binding adaptive coronavirus Critical database defined Early detection Efficiency effort escape evaluated Evolution of SARS-CoV-2 exhibiting flexibility Frequency Genotype genotypes geographical location global efforts identify Immune escape increase in independent investigated Lineage Local maintain MONITOR Mutation mutational hotspot Mutational hotspots mutations N-terminal domain Neutralizing antibodies neutralizing antibody NTD Phylogenetic phylogenies Phylogeny positioned Potential Protein Receptor-binding domain recruitment residue SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 lineage sequence sequences spike spike mutations spike NTD Spike protein Substitution Surveillance the receptor-binding domain the SARS-CoV-2 the Spike Viral viral evolution virulence virus W152 [DOI] 10.3390/v13112114 PMC 바로가기 [Article Type] Article
The evolution of the mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and AmericaArticle Published on 2021-10-092022-10-28 Journal: ArXiv [Category] COVID-19, [키워드] America antibody complementary COVID-19 disrupt domain drugs Europe Evolution favor Frequency Infectivity mechanism Mutation natural selection neutralize occurred Occurrence pathway Protein RBD recent reduced SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genomes trajectory Transmission vaccination rate Vaccine vaccine-breakthrough vaccine-resistant mutation viral evolution viral infectivity virus Y449S PMC 바로가기 [Article Type] Article
Review of the mechanisms of SARS-CoV-2 evolution and transmissionArticle Published on 2021-09-152022-10-28 Journal: ArXiv [Category] COVID-19, [키워드] acute respiratory syndrome antibody Beta binding affinity change complementary coronavirus COVID-19 creating deep learning Delta domain driven by E484K Epsilon Evolution expected Gamma Infectivity K417N L452R Lambda mechanism mechanism of evolution molecular mutate Mutation natural selection organism over pathway Persistent homology Population predict RBD RBD residues regulated remained residue review SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variant significantly more T478K the spike protein Therapies Transmission transmission pathway Vaccine vaccine-resistant Vaccines variant variants viral evolution with COVID-19 PMC 바로가기 [Article Type] Article
Emerging vaccine-breakthrough SARS-CoV-2 variantsArticle Published on 2021-09-092022-10-28 Journal: ArXiv [Category] COVID-19, [키워드] acute respiratory syndrome antibodies antibody Belgium Beta Brazil Canada co-mutations coronavirus coronavirus disease COVID-19 COVID-19 vaccines deep learning Delta Denmark develop domain E484K Evolution explain France Gamma genotyping Germany growth India Infection Infectivity Italy K417N L452R Lambda likelihood mAbs mechanism molecular mechanism monoclonal antibody Mutation natural selection Netherland patients populations predict Protein RBD Receptor-binding domain SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 transmission SARS-CoV-2 variant T478K the S protein the United State topological data analysis United Kingdom unvaccinated populations Vaccine vaccine-breakthrough vaccine-escape vaccine-resistant Vaccines variant variants viral evolution virulence PMC 바로가기 [Article Type] Article
Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks급성 SARS-CoV-2 감염은 숙주 내 다양성이 제한적이며 엄격한 전송 병목 현상을 통해 전송됩니다.Research Article Published on 2021-08-232022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] bottleneck can be used characterized circulating Combination Community consensus genome Control Course Critical dataset Diversity epidemiologically Evidence Evolution generate genetic diversity Host hosts Immune escape individual individuals infected individual infected individuals Infection infections iSNVs Laboratory Lineage majority Metrics nucleotide pace phylogenetically raised RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 lineage sequenced Single nucleotide variant Transmission transmitted understanding unique variant variants Variation virions virus viruses [DOI] 10.1371/journal.ppat.1009849 PMC 바로가기 [Article Type] Research Article
Characterization of SARS-CoV-2 worldwide transmission based on evolutionary dynamics and specific viral mutations in the spike protein스파이크 단백질의 진화 역학 및 특정 바이러스 돌연변이를 기반으로 한 SARS-CoV-2 전 세계 전파 특성Research Article Published on 2021-08-212022-09-10 Journal: Infectious Diseases of Poverty [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antibody test antigenicity appear binding affinity caused characterization China clade Cluster Clustering composed coronavirus disease Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 pandemic E484K early stage enzyme evolutionary dynamics facilitate followed by Frequency full-length GISAID database HEK293T cell HEK293T cells immune evasion independent information isolate isolates Italy Japan Malaysia mutants mutated Mutation neutralizing antibody pandemic predicted pseudovirus pseudoviruses R package Receptor-binding domain respiratory Result S477N SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 strain SARS-CoV-2 strains sequence Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 significantly Singapore Spike protein supplementary material tested the binding affinity the receptor-binding domain the spike protein Transmission transmission of SARS-CoV-2 USA V367F Viral viral infectivity viral mutation wild-type counterpart [DOI] 10.1186/s40249-021-00895-4 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamstersArticle Published on 2021-08-172022-10-04 Journal: Nature Communications [Category] MERS, SARS, 진단, [키워드] Anti-inflammatory cause changes in characterized Contact dependent on disease disease manifestation disease severity driven by Efficiency hamster immune increase in intranasal magnitude Manifestations outcome Pathogenesis pathogenic pathology respiratory virus SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 transmission severity subject susceptible Transmission transmission route Viral transmission virus load weight loss [DOI] 10.1038/s41467-021-25156-8 PMC 바로가기 [Article Type] Article
Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodiesSARS-COV-2 스파이크 단백질에서의 시그니처 중화 항체로의 탈출Research Article Published on 2021-08-052022-08-13 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding ACE2 receptor Affect Alter Amino acid amino acid substitution amino acids Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody neutralization binding Cell changes in circulating Combination convalescent core COVID-19 Critical Determining develop diagnostics E484K elicited engage enzyme evade Evolution explanation grid Host host immunity hotspot identify Immune escape immune escape mutants immune evasion in silico increase Infection Interaction K417N lentivirus MONITOR Mutation mutations N501Y Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing-antibody Pandemics Protein provide provided pseudotyped lentiviruses Recognition reduce responses SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus SARS-CoV2 sera shown signature specificity Spike protein target targets tested the spike protein Therapies understanding vaccination Vaccine variants variants of concern Viral Viral protein virion virus [DOI] 10.1371/journal.ppat.1009772 PMC 바로가기 [Article Type] Research Article
A Sanger-based approach for scaling up screening of SARS-CoV-2 variants of interest and concern관심 및 우려의 SARS-CoV-2 변종에 대한 스크리닝을 확대하기 위한 Sanger 기반 접근 방식Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, [키워드] A570D approach B.1.1 characteristic characterized COVID-19 pandemic COVID-19 sample E484K evaluated Frame genetic material identify Laboratory limitation Lineage lineages molecular molecular surveillance N501Y new SARS-CoV-2 P.1 P.2 Patient PCR protocol protocols public health RBD reagent Sanger sequencing SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 surveillance SARS-CoV-2 variant SARS-CoV-2 variants of concern Spread Surveillance Time frame variants of concern virus VoC VOCs WGS whole-genome sequencing worldwide pandemic [DOI] 10.1016/j.meegid.2021.104910 PMC 바로가기 [Article Type] Article
Spike protein mutational landscape in India during the complete lockdown phase: Could Muller’s ratchet be a future game-changer for COVID-19?완전한 잠금 단계 동안 인도의 스파이크 단백질 돌연변이 환경: 뮬러의 래칫이 COVID-19의 미래 게임 체인저가 될 수 있습니까?Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 치료기술, [키워드] analyzed ancestor attachment Complete complex complexes correlated strongly correlation country COVID-19 pandemic D614G variant declining disease severity docked effective Epidemiology Evolution evolutionary dynamics Fatality rate fusion geographic locations GISAID database host cell host receptor increase in India isolate lockdown molecular docking Muller Muller's ratchet Mutation mutation rate Mutational meltdown Prevent preventive measure Protein R 2 SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 virus sequence sequences social distancing spike spike glycoprotein Spike protein stability the spike protein treatment approach treatment approaches unique variant variants Viral evolutionary dynamics. virus Virus evolution virus spread Wuhan [DOI] 10.1016/j.meegid.2021.104874 PMC 바로가기 [Article Type] Article