SARS-CoV-2 strains – Page 6 – Communicable Diseases Research

Development of a genotyping platform for SARS-CoV-2 variants using high-resolution melting analysis

고해상도 용융 분석을 이용한 SARS-CoV-2 변이체 유전자형 플랫폼 개발

Article

Published on 2021-09-012022-09-11
Journal: Journal of infection and chemotherapy : official j [Category] SARS, 변종,

Whole Genome Sequencing of SARS-CoV-2 Strains in COVID-19 Patients From Djibouti Shows Novel Mutations and Clades Replacing Over Time

Medicine

Published on 2021-09-012022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan

파키스탄의 첫 번째 코비드 -19 파에서 SARS-COV-2 게놈에서 관찰 된 더 높은 엔트로피

Research Article

Published on 2021-08-312022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 변종,

[키워드] (RdRp 5’ UTR Analysis B.1 B.6 Capital change clade clades COVID-19 D614G Diversity Evolution except for exhibited Genetic Genome genome sequence genomes glycoprotein highest investigated isolates Laboratory lead material Mutation mutation rate Mutation rates not significant pandemic Phylogeny Q57H RdRP relative Result RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 strain SARS-CoV-2 strains selection pressure sequence sequences Site spike spike glycoprotein stability strain Strains subsequent territory transmitted virus were used
[DOI] 10.1371/journal.pone.0256451 PMC 바로가기 [Article Type] Research Article

Characterization of SARS-CoV-2 worldwide transmission based on evolutionary dynamics and specific viral mutations in the spike protein

스파이크 단백질의 진화 역학 및 특정 바이러스 돌연변이를 기반으로 한 SARS-CoV-2 전 세계 전파 특성

Research Article

Published on 2021-08-212022-09-10
Journal: Infectious Diseases of Poverty [Category] MERS, SARS, 변종, 진단,

[키워드] ACE2 acute respiratory syndrome affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antibody test antigenicity appear binding affinity caused characterization China clade Cluster Clustering composed coronavirus disease Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 pandemic E484K early stage enzyme evolutionary dynamics facilitate followed by Frequency full-length GISAID database HEK293T cell HEK293T cells immune evasion independent information isolate isolates Italy Japan Malaysia mutants mutated Mutation neutralizing antibody pandemic predicted pseudovirus pseudoviruses R package Receptor-binding domain respiratory Result S477N SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 strain SARS-CoV-2 strains sequence Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 significantly Singapore Spike protein supplementary material tested the binding affinity the receptor-binding domain the spike protein Transmission transmission of SARS-CoV-2 USA V367F Viral viral infectivity viral mutation wild-type counterpart
[DOI] 10.1186/s40249-021-00895-4 PMC 바로가기 [Article Type] Research Article

Molecular epidemiology analysis of early variants of SARS-CoV-2 reveals the potential impact of mutations P504L and Y541C (NSP13) in the clinical COVID-19 outcomes

SARS-CoV-2의 초기 변이체에 대한 분자 역학 분석은 임상 COVID-19 결과에서 돌연변이 P504L 및 Y541C(NSP13)의 잠재적 영향을 보여줍니다

Article

Published on 2021-08-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation Amino acid Amino acid variations Analysis analyzed Canada caused Characteristics clade contribute coronavirus country COVID-19 death demonstrated detect Effect Epidemiology Evolution Fatality rate feature functional Genetic variation Genetic variations Genome Genotype global pandemic identify Infection involved Mutation nonsynonymous nsp13 ORF1 ORF1ab outcome outcomes performed Phylogenetic analysis Phylogenetic tree Prevent proportion Report date Result reveal SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 strains. sequence Sequence alignment severe acute respiratory syndrome Coronavirus state strain Strains the United State The United States United States variant variants variants of SARS-CoV-2 Variation variations virus Washington
[DOI] 10.1016/j.meegid.2021.104831 PMC 바로가기 [Article Type] Article

MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19

Research article

Published on 2021-08-012022-10-05
Journal: Journal of Mass Spectrometry and Advances in the Clinical Lab [Category] 바이오마커, 변종, 진단,

[키워드] liquid chromatography mass spectrometry ACE2angiotensin-converting enzyme 2 Analysis analyzed angiotensin-converting enzyme 2 area under the curve Asymptomatic AUCarea under the curve Biomarker Cohort Concordance controls Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 testing COVID-19coronavirus disease 2019 CT cycle threshold demonstrated develop diagnostic Diagnostic method dithiothreitol DTTdithiothreitol E Proteinenvelope protein Emergency use authorization envelope protein EUAemergency use authorization FDAFood and Drug Administration Food and Drug Administration human donor human serum IgAimmunoglobulin A IgGimmunoglobulin G IgMimmunoglobulin M immunoglobulin A Immunoglobulin G immunoglobulin M immunoglobulins inactivated LC-MS limit of detection limitation LoDlimit of detection M Proteinmembrane protein MALDI-ToF MSmatrix-assisted laser desorption/ionization-time of flight mass spectrometry matrix-assisted laser desorption/ionization-time of flight mass spectrometry membrane protein N Proteinnucleocapsid protein nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Non-invasive NPnasopharyngeal nucleocapsid protein pilot study platform positive individuals Protein proteome RBDReceptor Binding Domain receiver operating characteristic Receptor binding domain Reverse transcriptase quantitative polymerase chain reaction Ribonucleic acid RNARibonucleic acid ROCreceiver operating characteristic RT-qPCR S Proteinspike protein Saliva SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 virus SARS-CoV-2severe acute respiratory syndrome coronavirus 2 sensitivity severe acute respiratory syndrome coronavirus 2 specificity specimen Spike protein VEPviral envelope protein viral envelope protein WHOWorld Health Organization with COVID-19 World Health Organization
[DOI] 10.1016/j.jmsacl.2021.09.001 [Article Type] Research article

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage

SARS-CoV-2 스파이크 단백질의 D614G 대체는 강화된 푸린 매개 스파이크 절단을 통해 융합체 형성 및 바이러스 역가를 증가시킵니다

Research Article

Published on 2021-07-272022-09-10
Journal: mBio [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Cell cleavage coronavirus D614G D614G substitution enhanced enhancement expressing S protein Formation furin furin cleavage site furin inhibitor increase isolates mechanism Mutation Plaque assay promote Protein rapid expansion respiratory S protein S proteins SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus significantly higher spike Substitution syncytium syncytium formation the S protein titer Transmissibility Treatment variant Viral viral isolate virus titer
[DOI] 10.1128/mBio.00587-21 PMC 바로가기 [Article Type] Research Article

Viral MicroRNAs Encoded by Nucleocapsid Gene of SARS-CoV-2 Are Detected during Infection, and Targeting Metabolic Pathways in Host Cells

SARS-CoV-2의 뉴클레오캡시드 유전자에 의해 암호화된 바이러스성 MicroRNA는 감염 중에 감지되고 숙주 세포에서 대사 경로를 표적화합니다

Communication

Published on 2021-07-122022-09-11
Journal: Cells [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제,

[키워드] absence association Biomarker Biosynthesis Calu-3 cell lines cellular interactions cellular metabolism conserved COVID-19 COVID-19 patients Critical deep sequencing disease disease pathogenesis DNA and RNA dysregulation effective expression functional Gene Expression host target genes identify immune dysregulation in silico analysis induce infective initial screening mapped mechanism metabolic metabolism microRNA MicroRNAs miRNA miRNAs N gene Pathogenesis pathogenesis of COVID-19 pathophysiology pathway Prevalence RNA sequence RNA viruses SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 strains selected shown Support target targeting the SARS-CoV-2 genome Therapeutic strategies therapeutic strategy Treatment v-miRNA v-miRNAs Vero E6 Viral Viral load viral miRNAs virus virus production viruses
[DOI] 10.3390/cells10071762 PMC 바로가기 [Article Type] Communication

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

Article

Published on 2021-07-102022-11-01
Journal: Cell Reports [Category] COVID-19, SARS,

[키워드] Abstract Administered antibody Antibody neutralization Antibody Response attenuate B.1.1.28 B.1.351 B.1.617.1 Bone marrow chimpanzee adenovirus-vectored vaccine Complete COVID-19 cross-protection cross-protective dose dose response dose-dependent manner Durability Efficacy function IgA IgG Immunity immunization immunogenic induce inhibitory intranasal intranasally long-lived plasma cell Lower respiratory tract mice mucosal immunity neutralized Neutralizing Pathogenesis PROTECT protection Protective provide reported robust SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant secreting serum serum antibody Spike protein trials vaccination Vaccine vaccine dose variant variants of concern viruses
[DOI] 10.1016/j.celrep.2021.109452 PMC 바로가기 [Article Type] Article

Predictive Value of Precision-Cut Lung Slices for the Susceptibility of Three Animal Species for SARS-CoV-2 and Validation in a Refined Hamster Model

Article

Published on 2021-06-302022-10-28
Journal: Pathogens [Category] COVID-19,

[키워드] activity acute respiratory syndrome addition administration Analysis animal animal model animal models Body weight loss can be used Cell culture coronavirus dose evaluated Evidence experiment facilitate group hamster Hamster model hamsters Health histological change histology scores in silico in vitro Inclusion incubated infection with SARS-CoV-2 inoculated intranasal route investigated lung Lung pathology Lungs Model oropharyngeal swab parameter pathology pig precision-cut lung slices quantification Receptor binding reducing replicated Replication Research respiratory tissue robust SARS-CoV-2 SARS-CoV-2 strains scoring system semi-quantitative sensitivity slice Specy susceptibility susceptibility to infection validation value Viral load virus replication viruses was obtained
[DOI] 10.3390/pathogens10070824 PMC 바로가기 [Article Type] Article