The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis
Research Article
[키워드] activate
activating
Activation
acute respiratory syndrome
addition
administration
analyses
assays
caused
Cell
cellular
complementary
confocal microscopy
coronavirus
cytoplasm
decrease
decreased expression
Deleterious
demonstrated
determinant
domain
E protein
Elimination
envelope
Epidemic
exacerbated
functional
genetics
highlight
immune response
immunopathology
in vivo
increase in
induce
infecting
Infection
Inflammation
Inflammatory cytokine
Inflammatory cytokines
inhibitor
interact
Interaction
interactions
involved
lung
lung damage
MAPK
mice
modulating
Mortality
motif
nucleus
overexpression
parental
pathway
potential therapeutic target
Protein
Proteins
proteomic
recombinant
reduce
reduction in
respiratory
SARS-CoV
SARS-CoV E
SARS-CoV infected cells
SARS-CoV infection
siRNA
survival
triggered
triggering
virulence
virus
virus attenuation
was reduced
yeast
[DOI] 10.1371/journal.ppat.1004320 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1004320 PMC 바로가기 [Article Type] Research Article