Safety, immunogenicity, and immune persistence of two inactivated COVID-19 vaccines replacement vaccination in China: An observational cohort studyArticle Published on 2022-09-162022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] administration Adverse reaction All participant anti-SARS-CoV-2 approved BBIBP-CorV can be used China Complete control group COVID-19 COVID-19 vaccine Cytopathic effect dose doses first dose geometric mean concentration geometric mean titer GMCs GMTs healthy immune persistence immunogenicity Immunoglobulin inactivated Inactivated vaccine Mild mitigate moderate NAb National not different not significantly different observation Observational cohort study Pragmatic regimens replacement Replacement vaccine Safety safety profile SARS-CoV-2 strain second dose sera severity Standard subject vaccination WHO [DOI] 10.1016/j.vaccine.2022.08.037 PMC 바로가기
Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived VariantsArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 Basis binding binding affinity binding mechanism changes in complexes coronavirus Cross-species transmission cryo-EM cryo-EM structure demonstrated examined expressing F486L facilitate highlight hosts Human human cell human monoclonal antibodies humans identify indicated Infection information Interaction mechanism Microscopy mink molecular mechanism Mutation N501T neutralized prevented Protein pseudovirus RBD RBD variant RBD variants receptor reduced residue SARS-CoV-2 SARS-CoV-2 variant sera Structure the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 transmitted variant variants virus entry viruses Y453F [DOI] 10.1128/jvi.00814-22 PMC 바로가기
Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2Article Published on 2022-09-142022-10-06 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Analysis antibodies BA.1 BA.2 BNT162b2 vaccine change COVID-19 COVID-19 pandemic D614G determinant domain driven by Evolution examined functional hinge region immune evasion Impact individual introduced MOST Mutation N-terminal neutralization omicron other variant pandemic Protein reduced SARS-CoV-2 SARS-CoV-2 variant sensitivity sera spike Spike protein susceptibility the Spike therapeutic thought Transmission variant variant evolution. [DOI] 10.1016/j.chom.2022.07.006 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patternsArticle Published on 2022-09-142022-10-06 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody antigenic BA.2.12.1 BA.4 BA.5 convalescent COVID-19 Critical effective strategy favor identify immune Immune escape inactive monoclonal antibody MOST Neutralizing Neutralizing antibodies neutralizing antibody omicron polyclonal predominant provide reduction in resistance SARS-CoV-2 sensitivity sera serum sublineages. susceptibility Treatment vaccinated individual vaccinee variants viral evolution [DOI] 10.1016/j.chom.2022.07.002 PMC 바로가기 [Article Type] Article
Cross-Reactivity of SARS-CoV-2 Nucleocapsid-Binding Antibodies and Its Implication for COVID-19 Serology TestsArticle Published on 2022-09-142022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] Adequate Analysis analyzed antibody antibody tests B.1 can be used caused characterized conserved convalescent sera COVID-19 COVID-19 patient cross-reactive cross-reactivity diagnostic domain ELISA test epitope global pandemic Humoral immunity immunogenic Infection magnitude new coronavirus SARS-CoV-2 nucleocapsid Nucleocapsid phosphoprotein patients positive correlation Protein raised RBD Recombinant protein reduced SARS-CoV-2 SARS-CoV-2 strain selective sensitivity sera serology test serology tests spike Spread Test the SARS-CoV-2 Vaccine variants of concern virus VoC VOCs [DOI] 10.3390/v14092041 PMC 바로가기
Improved Neutralisation of the SARS-CoV-2 Omicron Variant following a Booster Dose of Pfizer-BioNTech (BNT162b2) COVID-19 VaccineArticle Published on 2022-09-132022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] B.1.1.529 BNT162b2 collected COVID-19 dose evade Immunity Improved Lineage Mutation neutralisation assay neutralise neutralising Neutralising Antibodies neutralising antibody titre omicron Pfizer-BioNTech Pfizer-BioNTech BNT162b2 raising reduced SARS-CoV-2 sera the receptor-binding domain the SARS-CoV-2 the spike protein Vaccine variant virus VoC World Health Organization [DOI] 10.3390/v14092023 PMC 바로가기
Antigenic cartography using sera from sequence-confirmed SARS-CoV-2 variants of concern infections reveals antigenic divergence of OmicronArticle Published on 2022-09-132022-11-15 Journal: Immunity [Category] SARS, 변종, 진단, [키워드] antibodies antigenic antigenic cartography circulating variants convalescent COVID-19 D614G death Effectiveness elicited Evolution had more Hospitalization Immune escape Immunity individual Infection neutralization Neutralizing activity omicron other variants Patient prevented question responses reveal SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant Seasonal influenza sera strain vaccination Vaccine Vaccines variants of concern virus VoC VOCs [DOI] 10.1016/j.immuni.2022.07.018 PMC 바로가기
Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection KineticsArticle Published on 2022-09-122022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome addition Analysis B.1 B.1.617.2 BAC BAC mutagenesis backbone Bacterial bronchial epithelial cells Carrying chromosome clinical comparable coronavirus Cytopathic effect disease Efficiency en passant mutagenesis epithelial cell line evaluate generate glycoprotein human lung Infection Infectious virus inhibitors isolate isolates Kinetics less Microscopy monoclonal antibody Mutagenesis Mutation neutralization nonstructural proteins nucleocapsid Numerous Post-vaccine Potential progression raise recombinant RNA role SARS-CoV-2 sera severity spike spike mutation spike mutations Spike protein Substitution suggested susceptible Syncytia Transmissibility Treatment variant viral fitness viral spike virus Virus life cycle VoC [DOI] 10.3390/v14092017 PMC 바로가기
Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunityArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] antibody archive authority Breakthrough infection cellular cellular immunity Coalition Council Delta delta variant early immune response European healthy controls Horizon Human immune response in healthy individual increase in individual Infection Inflammatory mediators inflammatory parameters information interferon gamma median time Mild Neutralizing activity Norway Nucleocapsid proteins omicron Patient Protein RBD Regional Result SARS-CoV-2 sera symptom onset the receptor-binding domain the SARS-CoV-2 university vaccinated individual vaccinated individuals Vaccine vaccine dose Vaccine-induced immunity variant Whole blood [DOI] 10.3389/fimmu.2022.964525 PMC 바로가기
Serum Proteome Signatures of Anti-SARS-CoV-2 Vaccinated Healthcare Workers in Greece Associated with Their Prior Infection StatusArticle Published on 2022-09-052022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected All participant analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 vaccination approach bioinformatics blood sample BNT162b2 mRNA Characteristics collected contribute contributed controls Course COVID-19 COVID-19 vaccination COVID-19 vaccine database differentially expressed down-regulated Gene ontology Greece humoral immune response identify IgG immune response Immune status individuals infected patient KEGG knowledge Kyoto LC-MS/MS majority mechanism molecular over pandemic pathogenic pathway Pfizer/BioNTech processed profiling analysis Protein proteome proteomics provided Quantitative RBD-specific IgG recipients Research SARS-CoV-2 SARS-COV-2 infection sera serum signature significantly status the SARS-CoV-2 Thessaloniki titer vaccinated individual vaccination Vaccine virus worker [DOI] 10.3390/ijms231710153 PMC 바로가기