Low-dose tocilizumab is associated with improved outcome and a low risk of secondary infection in severe COVID-19 pneumonia저용량 토실리주맙은 중증 COVID-19 폐렴에서 개선된 결과 및 낮은 2차 감염 위험과 관련이 있습니다Article Published on 2021-12-012022-09-12 Journal: International journal of clinical practice [Category] 진단, [키워드] age APACHE II score cause Clinical data clinical feature Comorbidity control group control patient Coronavirus disease 2019 COVID-19 Critical Cytokine storm death demographic died distinguishing dose Effect evaluated groups High-dose high-dose group hyper-inflammation IL-6 receptor Infection infection rate infiltration intravenously less low dose low-dose lower mortality lung damage mechanical ventilation Mortality mortality rate Non-invasive outcome Patient radiological receiving respiratory Retrospective study risk Risk factors Secondary infection Severe COVID-19 pneumonia severe pneumonia survived Symptom Tocilizumab tocilizumab administration treated two group [DOI] 10.1111/ijcp.14997 PMC 바로가기 [Article Type] Article
Real-life study on the pharmacokinetic of remdesivir in ICU patients admitted for severe COVID-19 pneumonia중증 코로나19 폐렴으로 입원한 중환자실 환자의 렘데시비르 약동학 실생활 연구Article Published on 2021-12-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] adenosine adenosine triphosphate AUC C max Cell Concentration COVID-19 GS-441524 ICU ICU patient ICU Patients intravenous intravenous infusion Liquid chromatography mass spectrometry metabolite nine nucleoside Patient patients pharmacokinetic pharmacokinetics plasma Pneumonia preliminary report RDV Remdesivir SARS-CoV-2 SARS-COV-2 infection Severe COVID-19 pneumonia Tandem mass spectrometry These data Treatment triphosphate UHPLC Variability [DOI] 10.1111/bcp.14895 PMC 바로가기 [Article Type] Article
ANI and BIS variations in supine and prone position during closed-tracheal suction in sedated and myorelaxed ICU patients with severe COVID-19: A retrospective study중증 COVID-19가 있는 진정 및 근이완 중환자실 환자에서 기관 폐쇄 흡입 중 앙와위 및 엎드린 자세에서의 ANI 및 BIS 변화: 후향적 연구Article Published on 2021-12-012022-09-11 Journal: Journal of clinical monitoring and computing [Category] SARS, 치료기술, [키워드] Analgesia Analgesia/nociception index ANIm ANOVA Bispectral index Care COVID-19 COVID-19 pneumonia detect groups heart rate ICU ICU patient index intensive care intensive care unit median monitoring no difference noxious stimuli Patient patients hospitalized Prone position prone positioning repeated measure repeated measures retrieved Retrospective study SBP Sedation Severe COVID-19 pneumonia significantly statistically significant suction supine Supine position Systolic blood pressure tracheal Tracheal suction. Variation [DOI] 10.1007/s10877-020-00612-w PMC 바로가기 [Article Type] Article
Association between coronary artery calcifications and 6-month mortality in hospitalized patients with COVID-19코로나19로 입원한 환자의 관상동맥 석회화와 6개월 사망률의 연관성Observational Study Published on 2021-12-012022-09-11 Journal: Diagnostic and interventional imaging [Category] SARS, 임상, 치료기술, [키워드] 95% CI age association calcium cardiovascular disease categories Computed tomography conducted Coronary artery Coronary artery calcification Coronary artery disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 pneumonia detect evaluate Follow-up groups hospitalized patient initial magnitude material men Mild moderate Mortality mortality rate myocardial injury outcomes Patient patients hospitalized performed Pneumonia preventive treatment prospective observational cohort risk of death Severe COVID-19 pneumonia single-center Treatment with COVID-19 [DOI] 10.1016/j.diii.2021.06.007 PMC 바로가기 [Article Type] Observational Study
Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia A Randomized Clinical TrialCOVID-19 폐렴을 가진 입원 환자에서 중증 호흡 부전 또는 사망으로의 진행에 대한 하이 튜터 회복기 혈장의 효과 무작위 임상 시험Randomized Controlled Trial Published on 2021-11-292022-08-13 Journal: JAMA Network Open [Category] MERS, SARS, 임상, [키워드] 1:1 95% CI Adverse adverse events age clinical clinical end point clinical trial Composite control group convalescent plasma convalescent plasma group COVID-19 COVID-19 pneumonia CP and ST CP group CP plus ST CP plus standard therapy death defined did not reduce Effect Efficacy eligible enrolled Enrollment evaluate event experimental group failure finding fraction Glucocorticoids heparin high-titer anti–SARS-CoV-2 CP high-titer CP hospitalized patient hospitalized patients Importance infused intravenous IQR Italy Low–molecular weight heparin maximum measure mechanical ventilation Microneutralization test moderate to severe moderate to severe COVID-19 pneumonia modified intention-to-treat not significantly different objective occurred Odds ratio Open-label oxygen partial pressure participant Patient patients patients with COVID-19 patients with moderate plasma Pneumonia Point primary end point Primary outcome progression randomization randomized clinical trial randomized patient receive recommendations Registration Relevance Remdesivir respiratory Respiratory failure Result setting Severe COVID-19 pneumonia severe respiratory failure ST alone standard care Standard therapy the median treat treated Trial Volume volume of infused CP with COVID-19 worsening worsening respiratory failure [DOI] 10.1001/jamanetworkopen.2021.36246 PMC 바로가기 [Article Type] Randomized Controlled Trial
Treatment of COVID-19 Patients: Insights into the Use of Bone Marrow-Derived Mesenchymal Stem CellsConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 유전자 메커니즘, [키워드] 24 hour acute phase acute respiratory distress Administered administration administration of methylprednisolone adverse effect adverse event adverse events affected age alveolar ARDS association benefit bone Cell chronic obstructive Clinical improvement clinical trial Complete consolidation contributed Corticosteroid COVID-19 COVID-19 complications COVID-19 disease criteria CRP level death decrease defined discharged distress dose doses download drug Efficacy ferritin figure glucocorticoid High dose high mortality rate High-dose Hypothesis immunomodulatory effect include Inclusion increased risk Infection Inflammatory marker inflammatory markers insight intravenous dose intubation large cohort lung male marker median median age median time Methylprednisolone MSC observational study one patient Organizing pneumonia outcomes PaCO2 paO2/fiO2 PaO2/FiO2 ratio parameter Patient patient survival patients died patients with COVID-19 PCO2 phase primary endpoint procalcitonin pulmonary disease Pulmonary infection Randomized controlled trial reactive reducing reported respiratory parameters SARS-CoV-2 second dose secondary endpoint secure Severe COVID-19 pneumonia severity STEM stem cell suggested syndrome therapeutic option therapy Thorax tissue treat treated Treatment Trial Two patient Ventilator-associated pneumonia worsening [DOI] 10.1182/blood-2021-154291 [Article Type] Conference abstract
Effect of Intubation Timing on the Outcome of Patients With Severe Respiratory Distress Secondary to COVID-19 PneumoniaAnesthesiology Published on 2021-11-162022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 24 hour acute respiratory distress syndrome [ards] airway intubation Analysis analyzed baseline characteristics benefit Comorbidities coronavirus disease COVID-19 covid-19 respiratory failure Critically ill patient death deteriorate Detroit discharge distress Effect group groups healthcare providers Henry Ford High flow nasal canula higher risk hospital Hospital admission intensive care Intubated intubation Kaplan-Meier Kaplan-Meier survival curves mechanical ventilation Mortality nasal Observational cohort study observé organ dysfunction Organ failure outcome outcomes overall mortality Oxygenation pandemic Patient patients with COVID-19 performed Pneumonia post-hoc analysis Primary outcome question raised reduced risk respiratory respiratory rate Result Resuscitation retrospective risk ROX ROX index secondary secondary to Severe COVID-19 pneumonia Severe respiratory distress severe respiratory failure severe respiratory illness Significant significant difference significantly significantly higher significantly lower significantly more single-center SOFA SOFA score statistically significant difference subgroup of patient survival the timing therapy treated Treatment Ventilation while [DOI] 10.7759/cureus.19620 PMC 바로가기 [Article Type] Anesthesiology
The evolution of clot strength in critically-ill COVID-19 patients: a prospective observational thromboelastography studyResearch Published on 2021-11-062022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] activated acute respiratory distress syndrome (ARDS) Admission amplitude analysed Analysis bleeding Coagulation Coagulopathy Corona virus disease 2019 (COVID-19) COVID-19 COVID-19 coagulopathy COVID-19 patient critically-ill D-dimer difference Disseminated intravascular coagulopathy elevated evaluated Evolution fibrinogen Fibrinogen levels functional hypercoagulability hypercoagulable ICU ICU admission intensive care Laboratory limit mechanical ventilation mechanically ventilated non-survivor Non-survivors observation period parameter Patient patients patients with COVID-19 performed Platelet Prothrombin time reported Result Severe COVID-19 pneumonia significant difference significantly supplementary material survivor Thromboelastography (TEG) thrombosis variable was performed [DOI] 10.1186/s12959-021-00331-5 PMC 바로가기 [Article Type] Research
Sclerosing Encapsulating Peritonitis Following Recovery From COVID-19 PneumoniaEmergency Medicine Published on 2021-11-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abdomen abdominal cocoon abdominal pain acute respiratory syndrome bowel Case report Computed tomography coronavirus Coronavirus disease 2019 COVID-19 Critical demonstrated diagnosed Diagnosis Endotracheal intubation gastrointestinal involvement Injury intensive care manifestation Measures mechanical ventilation membrane Pain Patient patients with COVID-19 peritonitis Pneumonia positive remained reported Resection Respiratory illness Respiratory system RT-PCR SARS-CoV-2 Sclerosing sclerosing encapsulating peritonitis Seven Severe COVID-19 pneumonia the disease the SARS-CoV-2 virus was performed with COVID-19 [DOI] 10.7759/cureus.19306 PMC 바로가기 [Article Type] Emergency Medicine
Detection of Different COVID-19 Pneumonia Phenotypes with Estimated Alveolar Collapse and Overdistention by Bedside Electrical Impedance TomographyResearch article Published on 2021-11-032022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] acute respiratory distress alveolar Analysis ARDS biomedical imaging systems clinical variables collapse conducted control of voluntary movements COVID-19 decision support systems for the control of physiological detection Electrical impedance tomography Estimated help identify impedance IMPROVE information Locomotion outcome Patient patients PEEP phenotype Phenotypes Pneumonia positive reaction Recruitability reported Respiration Severe COVID-19 pneumonia syndrome the patient Treatment Trial [DOI] 10.1016/j.ifacol.2021.10.267 [Article Type] Research article