JAK1: Number one in the family; number one in inflammation?Supplement Papers Published on 2021-05-052024-09-04 Journal: Rheumatology (Oxford, England) [Category] 대상포진, [키워드] Cytokines Inflammation jak inhibitors JAK kinases rheumatoid arthritis Signal transduction spondyloarthritis spondyloarthropathies [DOI] 10.1093/rheumatology/keab024 PMC 바로가기 [Article Type] Supplement Papers
Transcriptional Landscape of Vero E6 Cells during Early Swine Acute Diarrhea Syndrome Coronavirus InfectionArticle Published on 2021-04-142022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] acute diarrhea autophagy cellular cellular transcriptome changes in coronavirus diarrhea differentially expressed gene disease down-regulated early infection enrichment analysis expression pattern gene expression profile highly pathogenic host-virus interaction hpi immune indicated Inflammatory response information investigated involved landscape molecular mechanism molecular mechanisms pathogenicity Post-infection Research RNA-sequencing SADS-CoV Signal transduction syndrome Transcription Transcriptome Vero E6 Vero E6 cell virus [DOI] 10.3390/v13040674 PMC 바로가기 [Article Type] Article
RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving FieldReview Published on 2021-04-042022-10-31 Journal: Cancers [Category] COVID-19, [키워드] αvβ3 αvβ6 accumulated Angiogenesis approach approaches binding Cancer cancer progression Cell cells Clinical studies clinical trials compounds diagnostic disease dose elevated Exosomes expression fibrosis field function functions high accuracy integrin integrin targeted therapy Integrins investigated knowledge Ligand ligands Metastasis molecular molecular imaging motif non-cancerous novel nuclear optical other diseases patient selection pharmacological progression receptors respiratory RGD-binding integrins SARS-CoV-2 SARS-COV-2 infection selective Sepsis Signal transduction simple subtype Subtypes synthetic synthetic integrin ligands target therapeutic target therapeutic targets therapy translation translational Treatment protocol treatment strategy Trial vascular normalization therapy viral infections [DOI] 10.3390/cancers13071711 PMC 바로가기 [Article Type] Review
Integrated intra‐ and intercellular signaling knowledge for multicellular omics analysis다세포 오믹스 분석을 위한 통합된 세포내 및 세포간 신호전달 지식Article Published on 2021-03-222022-09-12 Journal: Molecular Systems Biology [Category] 진단, [키워드] added affected Analysis annotation biological processe Computational biology Cytoscape Data analysis disease downstream facilitate homology individual cell information Interaction interactions intercellular Intercellular communication intercellular signaling intracellular signaling knowledge ligand‐receptor interactions Methods & Resources multicellular Omics integration over Pathways Protein protein complex provide provided Regulation resource resources SARS‐CoV‐2 infection Signal transduction Signaling signaling network transcriptional translation ulcerative colitis [DOI] 10.15252/msb.20209923 PMC 바로가기 [Article Type] Article
ARHGAP45 controls naïve T‐ and B‐cell entry into lymph nodes and T‐cell progenitor thymus seedingArticle Published on 2021-03-152023-08-30 Journal: EMBO Reports [Category] E형 간염, [키워드] ARHGAP45 Cell migration chemotaxis GTPase‐activating protein immunology lymphocyte regenerative medicine Signal transduction [DOI] 10.15252/embr.202052196 PMC 바로가기 [Article Type] Article
Saporin, a Polynucleotide-Adenosine Nucleosidase, May Be an Efficacious Therapeutic Agent for SARS-CoV-2 Infection폴리뉴클레오티드-아데노신 뉴클레오시다아제인 사포린은 SARS-CoV-2 감염에 효과적인 치료제가 될 수 있습니다Article Published on 2021-03-012022-09-11 Journal: SLAS discovery : advancing life sciences R & D [Category] 진단, 치료제, [키워드] (rRNA abasic site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenine agent Apoptosis Cell characteristic conserved coronavirus Coronavirus 2019 COVID-19 drug efficacious therapeutic enzymatic activity eukaryotic cells focus Genomic DNA high stability Hyperactivation Immunotherapy induce Infection inhibitor N-glycosidase Nucleosidase Pathways polymerase Protein protein synthesis residue respiratory ribosomal RNA RNA rRNA saporin. SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signal transduction Stress stress response therapeutic therapeutic agents toxin Treatment type I [DOI] 10.1177/2472555220970911 PMC 바로가기 [Article Type] Article
Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in ChinaPharmacology Published on 2021-02-252022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 3-drugs-3-formulas added Administered Anti-inflammatory Antiviral Antiviral effect build category China Chinese Chinese medicine complementary Complication COVID-19 Cytokine storm database Decoction disease drug Effects FIVE Government injection Laboratory mechanism medical need Medicine novel coronavirus disease outbreak Pathogenesis pathogenesis of COVID-19 pathway public health measure RAS-mediated bradykinin storm RBS Signal transduction Stage STAR systemic inflammation Systems biology TCM treat Treatment unique while [DOI] 10.3389/fphar.2020.615287 PMC 바로가기 [Article Type] Pharmacology
SARS-CoV-2/human interactome reveals ACE2 locus crosstalk with the immune regulatory network in the hostSARS-CoV-2/인간 상호작용체는 숙주의 면역 조절 네트워크와 ACE2 유전자좌 누화를 밝힙니다Article Published on 2021-02-192022-09-11 Journal: Pathogens and disease [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 receptor ACE2/AGT-axis activating Activation acute respiratory syndrome adrenal gland Altered angiotensin angiotensin-converting enzyme 2 approach axis binding blood pressure body tissues carboxypeptidase Cell cell cycle changes in Complication coronavirus COVID-19 cytokine database determine develop event gene expression profile globe Health help Host host immune system host protein Human human Angiotensin-converting enzyme human lung human tissue immune immune modulation immune response in viral Infection infection site Interaction involved kidneys Lineage locus lung Lungs mechanism mechanisms modulate molecular network Occurrence organs pancreas Placenta Primary infection Protein Proteins proteomic RAS receptor regulated regulatory network Renin renin-angiotensin system Replication respiratory reveal SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Severe acute respiratory syndrome Signal transduction small intestine Spike protein Testis tissues vascular remodelling Viral viral infection viral spike protein [DOI] 10.1093/femspd/ftab005 PMC 바로가기 [Article Type] Article
Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress플라스모디움 팔시파룸 구아닐릴 사이클라제-알파와 그 부가된 P4-ATPase 도메인의 활성은 cGMP 합성과 혈액 단계 탈출에 필수적이다.Research Article Published on 2021-01-262024-08-08 Journal: mBio [Category] 말라리아, [키워드] ATPase cyclic GMP malaria Plasmodium Signal transduction [DOI] 10.1128/mBio.02694-20 PMC 바로가기 [Article Type] Research Article
Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence신호 전달 경로 내 및 사이의 다면발광 및 상위성은 진균 독성의 유전적 구조를 정의합니다Research Article Published on 2021-01-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect amphotericin B Analysis antifungal drug resistance approach Author avirulent body temperature CAMP cascade Cell Cell signaling cellular cellular response Cellular responses characterization Combination complex component contribute cross Cryptococcal disease Cryptococcus cyclic AMP disease drug susceptibility drugs ENCODE epistatic interaction Europe Extracellular fungal Genes Genetic genetic architecture genetic difference genetic differences Genetic variation glycerol growth highlight human body Infection information isolate kinase Lineage locus make up mapping microbial modify molecular nucleotide osmolarity osmotic oxidative oxidative stress oxidative stress resistance pathogen pathogenicity Pathogens pathway phenotypic phenotypic variation physiological response pleiotropic polysaccharide capsule progeny promote protein kinase QTL Quantitative quantitative trait locus regulate regulator sensitivity Signal transduction Signaling signaling pathway strain Strains Stress temperate climates thought Tolerance traits underlie Variation virulence virulent [DOI] 10.1371/journal.pgen.1009313 PMC 바로가기 [Article Type] Research Article