COVID-19: No Guaranteed Protection from Future Infection after the Initial DiagnosisCase Series Published on 2021-03-302022-10-31 Journal: Case Reports in Infectious Diseases [Category] COVID-19, [키워드] acute respiratory symptom antibody Antibody Response antigenic Asymptomatic Community comparable COVID-19 COVID-19 research COVID-19 virus evade Future immune response Immunity infected with COVID-19 Infection Influenza Influenza virus initial MERS-CoV Mild new strain occur Patient positive protection question remained SARS-CoV-1 similarities subset Surveillance tested Treatment vaccination varicella virus viruses [DOI] 10.1155/2021/6617719 PMC 바로가기 [Article Type] Case Series
Repurposing of approved drugs with potential to interact with SARS-CoV-2 receptorResearch Article Published on 2021-03-292022-10-04 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] Abstract ACE ACE1 ACE2 addition Amino acid Analysis angiotensin approved drug binding Cell comparable coronavirus 2 COVID-19 distribution domain Drug repurposing entry of SARS-CoV-2 enzyme epithelial expression homolog host cells host-virus interaction human cells human lung Image Infection Interaction interfere low expression organized peptidase predict primary sequence Proteins RBD receptor Receptor binding domain Region reported repurposing respiratory S protein same order SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 spike protein similarities similarity spike glycoprotein Spike protein the SARS-CoV-2 tissue Transmission variety viral spike protein X-ray crystallographic structure [DOI] 10.1016/j.bbrep.2021.100982 PMC 바로가기 [Article Type] Research Article
COVID-19 Discourse on Twitter in Four Asian Countries: Case Study of Risk Communication아시아 4개국 트위터 코로나19 담론: 리스크 커뮤니케이션 사례 연구Multicenter Study Published on 2021-03-162022-09-10 Journal: Journal of Medical Internet Research [Category] SARS, 치료기술, [키워드] aligned Analysis Asian automatically caused collected communication coronavirus country COVID-19 Critical data set discourse disease outbreak early phase evaluated Evolution global effort global efforts global pandemic hate speech Health Organization identify India infodemic infodemiology information infoveillance Internet Iran latent Dirichlet allocation media misinformation natural language natural language processing objective outbreak pandemic plethora Research Result risk Risk communication SARS-CoV-2 similarities similarity social media South Korea suggested the disease the epidemic Topic topic modeling topic phase detection Transition phase Twitter was collected World Health Organization [DOI] 10.2196/23272 PMC 바로가기 [Article Type] Multicenter Study
Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey이탈리아에서 SARS-CoV-2 유행 중 SARS-CoV-2 감염과 일시적으로 연관된 가와사키병 및 소아 염증성 다계 증후군 정의: 국가, 다기관 설문조사 결과Observational Study Published on 2021-03-162022-09-01 Journal: Pediatric Rheumatology Online Journal [Category] SARS, 임상, 진단, [키워드] abnormality Acetylsalicylic acid age cardiac Cardiogenic shock characterized Chi square Chi square test Child child health children Clinical characteristics clinical feature Clinical features clinical manifestation clinical manifestations Cohort collected Complication complications Coronary artery Coronary artery abnormalities CRP levels database deaths demographic determine diagnosed disease elevated enrolled Evidence exact Fisher test ferritin Florence glucocorticoid Glucocorticoids group hospital Hypotension ICU admission Immunoglobulin immunoglobulins Inflammatory inflammatory disease Inflammatory diseases information IRCCS Italian IVIG Kawasaki disease laboratory data lymphopenia Mann-Whitney test Maternal multicenter Multisystem inflammatory syndrome associated with coronavirus disease myocarditis National no statistical difference Occurrence Older Older age outcome Patient patients pediatric Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection PIMS positive relationship respiratory response to treatment Result risk SARS-CoV-2 SARS-CoV-2 epidemic SARS-COV-2 infection Shock significantly similarities similarity Society supplementary material syndrome Treatment Treatment response Trieste troponin Troponin-T two groups were used [DOI] 10.1186/s12969-021-00511-7 PMC 바로가기 [Article Type] Observational Study
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of deathCOVID-19 투석 환자의 종단 단백질 프로파일링은 사망의 중증도 및 예측 인자를 나타냅니다Research Article Published on 2021-03-112022-09-10 Journal: eLife [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] adhesion molecules analyses Biomarkers Blood blood protein blood proteins blood sample CCL2 CCL7 changed circulating Clinical severity Combination correlated COVID-19 COVID-19 patient COVID-19 patients CTSD Cytokines damage death determine dialysis differentially expressed disease disease severity displaying drug end-stage kidney disease epithelial fatal COVID-19 fatal disease GDF15 help high risk hospitalised Human identifying IL18BP IL6 in some increased risk Inflammation Injury innate immune activation integrin Integrins Interaction involved joint kidney Kidney disease Kidney failure KRT19 linear mixed model longitudinal machine-learning marker Mild mild illness monocyte neutrophil neutrophil activation non-hospitalised non-infected Older other diseases pathology Patient patients patients with COVID-19 predict predictor problems profile Protein proteinase Proteins proteomic proteomics recruitment resource reveal severe COVID-19 severe disease severe disease progression severity similarities statistical survival analysis targets These data tissue tissue injury tissues [DOI] 10.7554/eLife.64827 PMC 바로가기 [Article Type] Research Article
The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 PandemicS2의 경우: COVID-19 팬데믹과 싸우는 면역원으로서 SARS-CoV-2 스파이크 단백질의 S2 서브유닛의 잠재적 이점Immunology Published on 2021-03-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] Accessibility Affect antibodies antibody Antibody-dependent enhancement Antigen antigen competition B-cells benefit common cold common cold Coronaviruses conserved coronavirus COVID-19 COVID-19 case COVID-19 cases cross-reactive Evidence exposure to Fighting glycan glycans highlight HIV-1 Immunity immunogen imperative include memory memory B-cell neutralization neutralizing antibody Perspective Population Potential potential benefit potential benefits produced Receptor-binding domain Research S2 subunit SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 vaccine similarities spike Spike protein Spike proteins stability steric T-cell T-cell responses T-cells target the receptor-binding domain the SARS-CoV-2 the spike protein therapy Vaccine Vaccine design Vaccines virus while [DOI] 10.3389/fimmu.2021.637651 PMC 바로가기 [Article Type] Immunology
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19SARS-CoV-2와 hemophagocytic lymphohistiocytosis 유전자의 상호 작용에 대한 네트워크 기반 분석은 COVID-19의 혈전증 매개체로서 호중구 세포외 트랩을 가리킵니다.Research Article Published on 2021-03-082022-09-10 Journal: PLoS Computational Biology [Category] SARS, 유전자 메커니즘, [키워드] abnormal coagulation acting Adults Algorithm Algorithms Analysis approach children circulating co-morbidities co-morbidity Coagulation concert condition consequence COVID-19 described disease Diseases Endothelium environmental condition environmental conditions Epidemic extracellular trap extracellular traps favor feature Genetic genetic information H1N1 H1N1 influenza hematologic hemophagocytic lymphohistiocytosis HLH Host host gene hyperinflammation Hypothesis identify Immune cell immune cells increase increased risk individual inflammatory condition inflammatory conditions inflammatory process inflammatory signal inflammatory signals Influenza information Interaction life-threatening likelihood manuscript mechanism mediators Metabolic disorders morbidities NET NETs network neutrophil Neutrophils Pathogenesis pathogenic pathway Pathways potential mechanism potential molecular predict presenting problem Pulmonary thromboembolism regulate responsible risk SARS-CoV-2 serious complication severe COVID-19 severely ill patient severely ill patients similarities similarity tested Thromboembolism thrombosis thrombotic thrombotic complication Thrombotic complications trajectory underlying condition underlying conditions vascular thrombosis Viral protein Viral proteins [DOI] 10.1371/journal.pcbi.1008810 PMC 바로가기 [Article Type] Research Article
Coronavirus biology and replication: implications for SARS-CoV-2코로나바이러스 생물학 및 복제: SARS-CoV-2에 대한 의미Review Published on 2021-03-012022-09-11 Journal: Nature reviews. Microbiology [Category] Coronavirus, SARS, 유전자 메커니즘, 치료제, [키워드] antiviral intervention Awareness cellular mechanism clinically coronavirus coronavirus biology Coronavirus infections coronavirus SARS-CoV Critical determinant effective intervention Efficacy Epidemics highlight highly pathogenic Host human population identify implication knowledge life cycle MERS-CoV molecular other coronavirus other coronaviruses preventive interventions raised review SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic severe disease similarities similarity Support target targets therapeutic Treatment viral life cycle Virus-host interaction Virus-host interactions Zoonotic introduction [DOI] 10.1038/s41579-020-00468-6 PMC 바로가기 [Article Type] Review
COVID-19 and autoimmune diseases코로나19와 자가면역질환Review Published on 2021-03-012022-09-11 Journal: Current opinion in rheumatology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome association Asymptomatic autoantibodies Autoimmune autoimmune conditions Autoimmune disease Autoimmune diseases Autoimmune response autoimmune responses Autoimmunity caused clinical manifestations conditions coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 in patient COVID-19 infection COVID-19 infections COVID-19 patient COVID-19 patients cross-reactivity develop disease evaluate hallmark host cells immune reaction immune response immune responses infected individual infected individuals Infection infection risk infection with SARS-CoV-2 Infectious disease lupus erythematosus medication organ Pathogenesis pathogenic mechanisms Patient patients with COVID-19 Prevent Prognosis proportion recent regimen reported respiratory risk of COVID-19 SARS-CoV-2 self-tolerance Severe acute respiratory syndrome severe COVID-19 infections severe disease similarities similarity syndrome systemic lupus erythematosus therapeutic effect treat Trigger [DOI] 10.1097/BOR.0000000000000776 PMC 바로가기 [Article Type] Review
Systemic Management of Pandemic Risks in Dental Practice: A Consolidated Framework for COVID-19 Control in DentistryMedicine Published on 2021-02-242022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] addressed agency airborne transmission of pathogens Analysis approach Care CDC center change clinical response clinician clinics conducted Control COVID-19 COVID-19 guideline dental dental procedure dentistry domain FIVE framework Guidance healthcare hierarchy of risk control Human implementation infection control infectious agents labor measure occupational organized overlap pandemic Patient patients Perspective PPE practice management dental prevention protocols provide provided risk Safety Secretary similarities Support systemic systems thinking workplace safety and health [DOI] 10.3389/fmed.2021.644515 PMC 바로가기 [Article Type] Medicine