Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions다학제적 접근 방식으로 SARS-CoV-2–ACE2 수용체 상호작용을 차단하는 후보로서 인간 ACE2 또는 SARS-CoV-2 스파이크 단백질에 결합하는 화합물 식별Research Article Published on 2021-03-302022-09-10 Journal: mBio [Category] SARS, 신약개발, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antiviral bind binding block blockade candidate causative agent cause caused cellular receptor Compound compounds coronavirus COVID-19 death demonstrated Diseases Dissociation constant dose-dependent drug Drug development Drug screening dual entry inhibitors enzyme evaluate Evans blue Human human ACE2 identify in vitro Infection Infectious disease inhibitor Interaction interfere Intervention library lifitegrast lumacaftor molecular docking Protein RBD RBD binders RBD-ACE2 receptor Receptor binding domain Registered repurposing respiratory SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sodium spike spike glycoprotein Spike protein SPR surface plasmon surface plasmon resonance targets the RBD the SARS-CoV-2 these compounds VERO-E6 virus was used [DOI] 10.1128/mBio.03681-20 PMC 바로가기 [Article Type] Research Article
Subtle Influence of ACE2 Glycan Processing on SARS-CoV-2 RecognitionResearch Article Published on 2021-02-192022-10-29 Journal: Journal of Molecular Biology [Category] COVID-19, MERS, SARS, [키워드] Abstract ACE2 ACE2 variants analyzed angiotensin-converting enzyme 2 binding cellular receptor glycan glycan engineering glycans glycoprotein glycosylated glycosylation human cells Impact influence Interaction LC-MS Modification modifications molecular basis N-linked glycan processing receptor Recognition SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral sensitivity severity sialic acid significantly Spike protein SPR suggested surface plasmon resonance variant viral spike virus was determined [DOI] 10.1016/j.jmb.2020.166762 PMC 바로가기 [Article Type] Research Article
A comprehensive review on plasmonic-based biosensors used in viral diagnostics바이러스 진단에 사용되는 플라즈몬 기반 바이오 센서에 대한 포괄적인 검토Review Published on 2021-01-152022-09-10 Journal: Communications Biology [Category] MERS, 진단, 치료기술, [키워드] absorption spectroscopy assist audience collected data COVID-19 pandemic Critical Diagnosis diagnostics disease disease control early diagnosis in viral information investigated Optical spectroscopy parameters Pathogens proliferation Research research and development scattering SPR surface plasmon surface plasmon resonance These data Transmission Viral viral infection virus virus detection viruses [DOI] 10.1038/s42003-020-01615-8 PMC 바로가기 [Article Type] Review
Blocking Effect of Demethylzeylasteral on the Interaction between Human ACE2 Protein and SARS-CoV-2 RBD Protein Discovered Using SPR TechnologyArticle Published on 2020-12-242022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] 2019-nCoV 293T cell accelerate ACE2 ACE2 protein acute respiratory syndrome affecting binding binding affinity blocking CAS compounds Concentration coronavirus COVID-19 drug Effect effective drug entry of SARS-CoV-2 experiment Health high affinity Human human Angiotensin-converting enzyme inhibit Interaction nontoxic novel coronavirus disease protein–protein interaction inhibitors pseudovirus pseudovirus infection receptor Receptor binding domain S-RBD SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 RBD Spike protein SPR surface plasmon resonance targeting technology the epidemic therapeutic strategy treat Treatment was used [DOI] 10.3390/molecules26010057 PMC 바로가기 [Article Type] Article
Inhibition of Porcine Epidemic Diarrhea Virus Replication and Viral 3C-Like Protease by QuercetinArticle Published on 2020-10-302022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, MERS, [키워드] 3C-like protease 3CL pro Analysis Antiviral binding affinity binding pocket caused concentrations coronavirus drug target effective energy transfer epidemic diarrhea exhibited indicated Infection inhibition inhibitory effect molecular docking PEDV Porcine epidemic diarrhea virus protease quercetin significantly SPR strain suppressed surface plasmon resonance Therapeutic treatment variant viral replication virus [DOI] 10.3390/ijms21218095 PMC 바로가기 [Article Type] Article
Recent Progress in Plasmonic Biosensing Schemes for Virus DetectionReview Published on 2020-08-222022-10-29 Journal: Sensors (Basel, Switzerland) [Category] COVID-19, MERS, [키워드] approaches Biomarker Colorimetric Combination complement coronavirus 2 coronavirus disease COVID-19 dengue virus detection Diagnostic method diagnostic methods Diseases Ebola virus effective Electrochemiluminescence ELISA enzyme-linked immunosorbent assay Hepatitis Infectious disease Influenza virus limitation LSPR Luminescence nanomaterials PCR Perspective plasmonics platform polymerase chain Progress public health quantification recent receptor respiratory SARS-CoV-2 scattering SERS SPR stability virus virus detection Zika virus [DOI] 10.3390/s20174745 PMC 바로가기 [Article Type] Review
Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbitsReport Published on 2020-06-082022-10-29 Journal: Science Translational Medicine [Category] COVID-19, [키워드] Analysis analyzed antibody antibody affinity antibody repertoire Antibody Response Antibody titer Antigen correlated strongly COVID-19 disease COVID-19 vaccine development cytoplasmic demonstrated domains ectodomain effective elicited ELISA enzyme epitope facilitate help higher affinity immunodominant epitope immunogen immunosorbent information lack Multiple neutralization assays neutralization titers neutralizing antibody performed RBD Receptor binding domain S1 domain S2 domain SARS-CoV-2 SARS-CoV-2 spike antigen SARS-CoV-2 spike genome SARS-CoV-2 spike protein Spike protein spike protein-based vaccines SPR the RBD the receptor-binding domain transmembrane domain understanding Vaccine vaccine candidate Vaccine design viral spike protein [DOI] 10.1126/scitranslmed.abc3539 PMC 바로가기 [Article Type] Report
Multiplexed Remote SPR Detection of Biological Interactions through Optical Fiber BundlesArticle Published on 2020-01-162023-08-30 Journal: Sensors (Basel, Switzerland) [Category] E형 간염, [키워드] biomolecular detection biosensor functionalization Label-free microstructuration Multiplexed detection Optical fiber SPR surface plasmon resonance [DOI] 10.3390/s20020511 PMC 바로가기 [Article Type] Article
Identification of UQCRB as an oxymatrine recognizing protein using a T7 phage display screenArticle Published on 2016-12-042023-06-18 Journal: Journal of ethnopharmacology [Category] B형 간염, [키워드] Chronic Hepatitis B ITC oxymatrine Oxymatrine (PubChem CID: 114850) SPR UQCRB. [DOI] 10.1016/j.jep.2016.08.007
Population dynamics of mosquitoes and malaria vector incrimination in district Charsadda, Khyber Pakhtunkhwa (KP) Pakistanarticle Published on 2015-01-312024-09-01 Journal: Family process [Category] 말라리아, [키워드] Anopheles Charsadda CSP ELISA Indoor collection SPR [Article Type] article