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[키워드] ACE-2 ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected age Ang II Ang II/AT1R axis angiotensin Angiotensin II Angiotensin-converting enzyme ARDS Asia AT1R balance blood pressure cardiovascular diseases cascade causative agent cellular receptor characterized Comorbidities Comorbidity complications coronavirus coronavirus disease Coronavirus disease 2019 correlation country COVID-19 Cytokine storm diabetes downregulation dual dysregulation effective electrolyte balance Europe Factor feature followed by Gender Genetic polymorphism genetic polymorphisms Health Organization higher risk Host host susceptibility factors human tissue Hypercoagulation individual Infection Interaction involved less lung Lungs mechanism morbidity Mortality Multiple organ damage organ damage organs other organs outcome overactivation pandemic pathogenicity pathology produced proinflammatory promote RAS RAS imbalance receptor renin–angiotensin system respiratory respiratory distress risk factor role SARS-CoV-2 severity spread to subsequent syndrome the disease type I underlying diseases Vaccine vasoconstriction Viral virus while WHO World Health Organization Wuhan Wuhan, China
[DOI] 10.3390/molecules26226945 PMC 바로가기 [Article Type] Review