Effect of home-based prehabilitation in an enhanced recovery after surgery program for patients undergoing colorectal cancer surgery during the COVID-19 pandemicRandomized Controlled Trial Published on 2021-12-012022-10-05 Journal: Supportive Care in Cancer [Category] SARS, 임상, [키워드] addition Analysis approved attenuate Body body composition change clinical study Colorectal cancer Complication complications conducted confinement Controlled clinical trial COVID-19 COVID-19 pandemic curative treatment Effect Effectiveness fat Fat mass home hospital Hospital stay lean mass Lean mass and fat mass lockdown Patient postoperative Prehabilitation. Randomized reduce Registered Registration standard care standard care group study group surgery the ethics committee were measured [DOI] 10.1007/s00520-021-06343-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Comparing the effectiveness of Atazanavir/Ritonavir/Dolutegravir/Hydroxychloroquine and Lopinavir/Ritonavir/Hydroxychloroquine treatment regimens in COVID-19 patientsCOVID-19 환자에서 아타자나비르/리토나비르/돌루테그라비르/하이드록시클로로퀸 및 로피나비르/리토나비르/하이드록시클로로퀸 치료 요법의 효과 비교Randomized Controlled Trial Published on 2021-12-012022-09-11 Journal: Journal of medical virology [Category] 임상, 치료제, [키워드] 95% CI activated administration Admission antibiotic aPTT assigned Atazanavir C-reactive protein C-reactive protein (CRP clinical and laboratory outcomes clinical and laboratory parameters confidence interval Corticosteroid COVID-19 COVID-19 patient dolutegravir Effectiveness evaluated groups Hospitalization Hydroxychloroquine ICU ICU admission INR intensive care intensive care unit International international normalized ratio invasive ventilation Kaletra Laboratory laboratory parameter Laboratory parameters less Lopinavir Lopinavir/ritonavir moderate moderate to severe mortality rate no difference normalized outcome partial thromboplastin time Patient Potassium Randomly receiving Ritonavir severe COVID-19 patient severe disease course standard care study groups THROMBOPLASTIN Treatment treatment period treatment regimen were recorded [DOI] 10.1002/jmv.27195 PMC 바로가기 [Article Type] Randomized Controlled Trial
Efficacy and safety of sofosbuvir plus daclatasvir or ravidasvir in patients with COVID-19: A randomized controlled trialCOVID-19 환자에서 소포스부비르와 다클라타스비르 또는 라비다스비르의 효능 및 안전성: 무작위 대조 시험Clinical Trial Published on 2021-12-012022-09-11 Journal: Journal of medical virology [Category] 신약개발, 임상, 치료제, [키워드] added addition Admission Antiviral antiviral drugs Antiviral treatment approved ARMS clinical impact coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 infections daclatasvir Day DCV Deterioration distress effective therapy Efficacy Efficacy and safety eligible patient endpoints evaluate Evidence evidence of Fever headache ICU ICU admission identify improvement incidence infections intensive care intensive care unit mechanical ventilation moderate moderate to severe Mortality negativity no evidence of Open-label open-label trial oxygen oxygen saturation Patient patients with moderate positive Randomized Randomized controlled trial ravidasvir RDV repurposing repurposing antiviral drugs respiratory distress Severe COVID-19 Infection severe COVID-19 infections significantly significantly lower sofosbuvir sofosbuvir plus daclatasvir standard care Standard of care Support Symptom Treatment Trial [DOI] 10.1002/jmv.27264 PMC 바로가기 [Article Type] Clinical Trial
Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trialRandomized Controlled Trial Published on 2021-12-012022-10-05 Journal: The Lancet. Respiratory Medicine [Category] SARS, 임상, [키워드] adverse event assigned Awake prone positioning Canada Care Clinique collaborative meta-trial country COVID-19 death defined Efficacy enrolled enrolment evaluate Fisher FIVE foundation France hazard ratio hypoxaemic respiratory failure IMPROVE in both groups incidence Innovation intention-to-treat analysis Intubated intubation Ireland meta-trial Mortality nasal NCT04325906 observational studies occurred Open-label outcome Oxygenation Patient patients with COVID-19 Prevent promotion prone positioning proportion randomised randomised controlled Randomised trial Randomly reduce Registered reported required Respiratory Support retrospective Rice risk severe COVID-19 Spain standard care Support Treatment Trial trials USA [DOI] 10.1016/S2213-2600(21)00356-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia A Randomized Clinical TrialCOVID-19 폐렴을 가진 입원 환자에서 중증 호흡 부전 또는 사망으로의 진행에 대한 하이 튜터 회복기 혈장의 효과 무작위 임상 시험Randomized Controlled Trial Published on 2021-11-292022-08-13 Journal: JAMA Network Open [Category] MERS, SARS, 임상, [키워드] 1:1 95% CI Adverse adverse events age clinical clinical end point clinical trial Composite control group convalescent plasma convalescent plasma group COVID-19 COVID-19 pneumonia CP and ST CP group CP plus ST CP plus standard therapy death defined did not reduce Effect Efficacy eligible enrolled Enrollment evaluate event experimental group failure finding fraction Glucocorticoids heparin high-titer anti–SARS-CoV-2 CP high-titer CP hospitalized patient hospitalized patients Importance infused intravenous IQR Italy Low–molecular weight heparin maximum measure mechanical ventilation Microneutralization test moderate to severe moderate to severe COVID-19 pneumonia modified intention-to-treat not significantly different objective occurred Odds ratio Open-label oxygen partial pressure participant Patient patients patients with COVID-19 patients with moderate plasma Pneumonia Point primary end point Primary outcome progression randomization randomized clinical trial randomized patient receive recommendations Registration Relevance Remdesivir respiratory Respiratory failure Result setting Severe COVID-19 pneumonia severe respiratory failure ST alone standard care Standard therapy the median treat treated Trial Volume volume of infused CP with COVID-19 worsening worsening respiratory failure [DOI] 10.1001/jamanetworkopen.2021.36246 PMC 바로가기 [Article Type] Randomized Controlled Trial
Protective potential of high-intensity interval training on cardiac structure and function after COVID-19: protocol and statistical analysis plan for an investigator-blinded randomised controlled trialCOVID-19 이후 심장 구조 및 기능에 대한 고강도 인터벌 트레이닝의 보호 가능성: 조사자 맹검 무작위 대조 시험을 위한 프로토콜 및 통계 분석 계획Article Published on 2021-11-182022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 Anti-inflammatory effects approved Capital Capital Region cardiac injury cardiac mass Cardiology Cardiopulmonary cardiorespiratory cardiorespiratory fitness changes in Committee control group COVID-19 Denmark discharged Ethics hospital Hypothesis hypothesise hypothesised IMPROVE Inconclusive Injury interval training Intervention life Lung function morbidity peer-reviewed positive protocol Quality of life randomised randomised controlled trial reduce reducing Region Registered registration number Safe Sex Sports Medicine standard care Statistical analysis plan survivor Symptom systemic inflammatory response Trial Registration Number [DOI] 10.1136/bmjopen-2020-048281 PMC 바로가기 [Article Type] Article
Stem cell-based therapy for COVID-19 and ARDS: a systematic reviewReview Article Published on 2021-11-082022-10-04 Journal: NPJ Regenerative Medicine [Category] 바이오마커, 임상, [키워드] acute respiratory distress addition adjuvant therapy analyzed ARDS ARDS patients article Care Case series Cell Cell-based therapy clinical investigation Clinical studies clinical study clinical trials Cohort compassionate use complications concerning coronavirus disease COVID-19 Critical death effective effective intervention Efficacy eight evaluate Evidence finding FIVE global effort immunological IMPROVE Inflammatory investigated Lung injury management moderate-to-severe COVID-19 MOST MSC MSCs performed phase positive reduce mortality rate reported Respiratory tract diseases Safe severe COVID-19 standard care STEM stem cell Stem cell therapy Stem-cell research Stem-cell therapies syndrome systematic review therapy therapy for COVID-19 treat Treatment treatments for COVID-19 viral infection was performed [DOI] 10.1038/s41536-021-00181-9 PMC 바로가기 [Article Type] Review Article
Safety and efficacy of autologous non-hematopoietic enriched stem cell nebulization in COVID-19 patients: a randomized clinical trial, Abu Dhabi 2020Research Published on 2021-11-032022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] 95% CI Abu adaptive Administered Adverse adverse events approval assessments autologous caused Cell center Clinical improvement Clinical outcome clinical trial cocktail Committee complement conducted Control control group coronavirus disease COVID-19 COVID-19 patients discharge effective Efficacy Emirate event exceptional experimental group hospital immunomodulation improvement include institutional review board Intervention IRB mortality rate Nebulizers and vaporizers occurred Open-label overall survival pandemic Patient patients Peripheral blood primary endpoint Randomized randomized clinical trial receiving Recovery of function reduce reduction reduction in Registered released reported Result Safe Safety SARS-CoV-2 seven-category ordinal scale severity standard care STEM stem cells Symptom therapy Treatment vaccination rates virus [DOI] 10.1186/s41231-021-00101-5 PMC 바로가기 [Article Type] Research
Evidence of Stability in Patient-Reported Global Health During the COVID-19 PandemicObservational Study Published on 2021-11-012022-10-05 Journal: Value in health : the journal of the International [Category] 임상, [키워드] adjusted age Care collected conducted COVID-19 COVID-19 pandemic cross-sectional decrease demonstrated evaluated evidence of finding global health Health health system health-related quality of life healthcare Healthcare system implication increases in Interpretation measure measurement mental health outcome pandemic Patient physical Quality of life receiving significantly standard care statistical Stressor System unique [DOI] 10.1016/j.jval.2021.06.009 PMC 바로가기 [Article Type] Observational Study
Can treatment with teicoplanin improve the prognosis of COVID-19 patients?Clinical Trial Published on 2021-11-012022-10-05 Journal: International journal of clinical practice [Category] SARS, 임상, [키워드] addition administration Adverse reaction Arm baseline characteristics Can clinical investigation Clinical outcome Comorbidity comparable control arm control group COVID-19 COVID-19 patients effect of treatment hospitalised patient IMPROVE laboratory-confirmed lower mortality mortality rate mortality rate; no significant difference organization outcome Patient patients with COVID-19 presenting symptoms Prognosis reported required Retrospective study significantly significantly lower standard care Teicoplanin teicoplanin. treated Treatment two groups with COVID-19 [DOI] 10.1111/ijcp.14752 PMC 바로가기 [Article Type] Clinical Trial