SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling
SARS-CoV-2 Orf6은 Nup98을 하이재킹하여 STAT 핵 수입을 차단하고 인터페론 신호를 길항합니다
530
[키워드] acute respiratory syndrome
acute respiratory syndrome coronavirus
addition
antagonistic
antagonize interferon signaling
Antiviral
antiviral action
antiviral response
antiviral signaling
arginine
bind
binding
C-terminal domain
causative agent
complex
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
Critical
Defense
disrupt
docking
Health
health problem
Host
Host immune response
host immune responses
IFN
IFN signaling
IFN-stimulated gene
IFN-stimulated genes
immune responses
impair
Infection
inhibit
interact
interferon
interferon signaling antagonism
ISGs
mechanism
methionine
NPC
nuclear
nuclear pore
nuclear translocation
Nup98
ORF6
overcome
pandemic
pathogenic virus
pathogenic viruses
Pathogens
pathway
Previous studies
previous study
Protein
Rae1
replicate
residue
respiratory
SARS-CoV
SARS-CoV-2
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
Significance
STAT
Stat1
STAT2
STATs
the interferon
transcriptional
Vaccines
Viral
viral pathogen
viral pathogens
virus
viruses
[DOI] 10.1073/pnas.2016650117 PMC 바로가기 [Article Type] 530
[DOI] 10.1073/pnas.2016650117 PMC 바로가기 [Article Type] 530