The Different Immune Responses by Age Are due to the Ability of the Fetal Immune System to Secrete Primal Immunoglobulins Responding to Unexperienced Antigens연령에 따른 다른 면역 반응은 미숙한 항원에 반응하는 원시 면역글로불린을 분비하는 태아 면역 체계의 능력 때문입니다Research Paper Published on 2022-01-012022-09-10 Journal: International Journal of Biological Sciences [Category] SARS, 유전자 메커니즘, [키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity age aging analyzed antibody Antigen Antiviral antiviral proteins Birth cells complement component components condition conditions coronavirus Coronavirus 2019 COVID-19 Critical Culture decrease demonstrated early pregnancy environmental factor EVs extracellular vesicle Extracellular vesicles Factor fetal fetal immune system form FSC HLA-G human leukocyte antigen Hypothesis IgG3 IgM immune reaction immune system immune systems immune tolerance Immunoglobulin immunoglobulin M immunoglobulins independent Infection Infectious disease Infectious diseases leukocyte mechanism mortality rate mutations NAbs natural antibody Pregnancy produced Protein Proteins respiratory Responding response responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus stem cell stem cells susceptible System [DOI] 10.7150/ijbs.67203 PMC 바로가기 [Article Type] Research Paper
Human mesenchymal stem cells treatment for severe COVID-19: 1-year follow-up results of a randomized, double-blind, placebo-controlled trialClinical Trial Published on 2022-01-012022-10-04 Journal: EBioMedicine [Category] 바이오마커, 임상, 치료법, [키워드] 1-year follow-up results administration adverse event analyzed antibody benefit Biomarkers Cell China clinical trial cohort study consequence COVID-19 COVID-19 patients double-blind Effectiveness enrolled evaluate Follow-up follow-up time foundation group High-resolution CT Human in both group incidence Innovation interval Lung function lung lesion Major median mesenchymal stem cell Mesenchymal stem cells treatment MSC natural Other outcome outcomes Patient phase 2 trial Placebo placebo-controlled trial plasma positive primary endpoint Program proportion Randomized RCT RCT. recorded recruited reduced Registered reported Science severe COVID-19 stem cell Symptom technology the placebo group Treatment treatment for COVID-19 Trial tumor marker two groups UC-MSC umbilical Volume walking distance [DOI] 10.1016/j.ebiom.2021.103789 PMC 바로가기 [Article Type] Clinical Trial
High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells인간 윤부 줄기세포에서 SARS-CoV2 바이러스 진입 관련 단백질의 고발현Article Published on 2022-01-012022-09-11 Journal: The Ocular Surface [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] ABCB5 ACE2 ACE2 expression ACE2 mRNA acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed caused Cell cell population cellular cellular tropism conjunctival coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 testing Culture datasets deficiency Donor epithelial cell epithelial cells evaluated Express expression expression value flow cytometry gene knockout immunohistochemistry knockdown Limbal stem cells mechanism ocular Ocular surface overexpression Patient PAX6 promote Protein Proteins qRT-PCR regulate Regulation RNA-Seq RNAseq SARS-CoV2 SARS-CoV2 infection severe acute respiratory syndrome Coronavirus siRNA stem cell stem cells susceptibility TMPRSS2 TMPRSS2 expression transcription factor Transmission routes transplantation viral entry was performed were assessed western blot while [DOI] 10.1016/j.jtos.2021.10.002 PMC 바로가기 [Article Type] Article
Establishment of Human Pluripotent Stem Cell‐Derived Skin Organoids Enabled Pathophysiological Model of SARS‐CoV‐2 Infection인간 다 능성 줄기 세포 유래 피부 오가 노이드의 확립 SARS -COV -2 감염의 병리 생리 학적 모델 가능Research Article Published on 2021-12-312022-09-10 Journal: Advanced Science [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 association can be used Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 death Drug screening epidermis Evidence feature finding hair follicle hair follicles Hair loss help Human identify infect investigated KRT17 lead Model molecular nerve cell nervous system Organoid pathological mechanism Patient proteome proteomics reported respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown skin skin cell skin organoids skin tissue STEM stem cell susceptibility [DOI] 10.1002/advs.202104192 PMC 바로가기 [Article Type] Research Article
Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy유전자 요법에서 아데노 바이러스 생물학, 재조합 아데노 바이러스 및 아데노 바이러스 사용Review Published on 2021-12-142022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] adenoviral vector Adenovirus adenovirus-based best Biology Cancer Cancer cells Cancer immunotherapy Cell clinical trial clinical trials conditionally replicating adenovirus COVID-19 vaccine COVID-19 vaccines cytokine ENhance Gene therapy insertion kill m-CRA methodological Modification oncolytic virus Patients with cancer platform pluripotent stem cells promoter recombinant regenerative regenerative medicine replicate replication-defective adenoviral vector stem cell subsequent survivin therapeutic therapeutic effects therapy Tumor tumors Usage Vaccine Vaccines Viral viral replication virus wild-type [DOI] 10.3390/v13122502 PMC 바로가기 [Article Type] Review
Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA systemResearch Article Published on 2021-12-032022-10-30 Journal: Life Science Alliance [Category] COVID-19, MERS, SARS, [키워드] adaptive Antiviral antiviral action Antiviral effect antiviral immunity Cell cell type Immunity In vitro infection increased expression Innate immunity knockout PIWIL2 Protein protein translation provided reduce reductions in RNA RNA fragment SARS-CoV-2 SARS-CoV-2 genome shown stem cell Viral RNA [DOI] 10.26508/lsa.202101240 PMC 바로가기 [Article Type] Research Article
Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial5 개의 면역 저하 환자 및 전향 적 개방형 임상 시험에서 건강한 대조군에서 SARS-COV-2에 대한 mRNA BNT162B2 백신의 안전성 및 효능Research paper Published on 2021-11-302022-08-13 Journal: EBioMedicine [Category] MERS, SARS, 임상, [키워드] Adverse adverse events Adverse reaction Allogeneic allogeneic hematopoietic stem cell transplantation Antibody titre antibody titres BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination CAR T, Chimeric antigen receptor T CAR-T Cell Cell therapy certain immunocompromised patient groups chronic lymphocytic leukemia clinical trial clinical trials CLL CLL, Chronic lymphocytic leukemia Control controls Council COVID-19, Coronavirus disease 2019 disorder Efficacy event excluded finding FIVE five group foundation funding generally mild group healthy control healthy controls Hematopoietic stem cell highlight HIV HIV, Human immunodeficiency virus HSCT, Allogeneic hematopoietic stem cell transplantation Human immunodeficiency virus human stem-cell transplantation Ibrutinib Immunity Immunocompromised Immunocompromised patient immunocompromised patient group Immunocompromised patients immunodeficiency disorder immunodeficiency disorders IMPROVE Infection ITT, Intention to treat Knut leukemia Lymphocytic leukemia mPP, Modified per protocol mRNA BNT162b2 vaccine mRNA vaccination mycophenolate mycophenolate mofetil occurred of BNT162b2 Open-label organ transplantation organization organizations Patient patient group patient groups PID, Primary immunodeficiency disorders PP, Per protocol primary endpoint Primary Immunodeficiency Prospective clinical trial Rate Region Safe Safety SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 second dose secondary endpoint Secondary endpoints selected serious adverse reaction Seroconversion seroconversion rate seroconverted solid organ solid organ transplantation SOT SOT, Solid organ transplantation stem cell subgroups subject Swedish T cell therapy Treatment vaccination against COVID-19 vaccine dose virus infection [DOI] 10.1016/j.ebiom.2021.103705 PMC 바로가기 [Article Type] Research paper
Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial DiseasesMicrobiology Published on 2021-11-302022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome antimicrobial agents application Bacteria bacterial EVs biogenesis cell types clinical complication component coronavirus death demonstrated described develop diagnostic disease early diagnosis Efficiency Escherichia coli EVs Extracellular vesicles HBV HCV Hepatitis B virus hepatitis C virus HIV Human immunodeficiency virus Impact Infectious disease lipids mechanism microbes microbial MSC-derived EVs nucleic acids Organisms Particle pathogen pathogenic microorganism peptides physiological platform produced Proteins responsible RNA SARS-CoV-2 Staphylococcus aureus STEM stem cell stem cells Therapeutic approach Therapeutic strategies therapy translation Treatment Vesicle Viral EVs virus [DOI] 10.3389/fmicb.2021.785856 PMC 바로가기 [Article Type] Microbiology
Stem Cells Therapy for COVID-19: A Systematic Review and Meta-AnalysisMedicine Published on 2021-11-292022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 2019 novel coronavirus 95% CI Analysis analyzed Cell therapy clinical outcomes Comprehensive control group coronavirus disease COVID-19 COVID-19 vaccination Efficacy evaluate fixed inclusion criteria mesenchymal stem cell morbidity mortality rate pandemic Patient patients with COVID-19 protocol reduce reducing mortality review risk SARS-CoV-2 significantly statistically significant STEM stem cell Stem cell therapy therapeutic option Version [DOI] 10.3389/fmed.2021.737590 PMC 바로가기 [Article Type] Medicine
Treatment of COVID-19 Patients: Insights into the Use of Bone Marrow-Derived Mesenchymal Stem CellsConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 유전자 메커니즘, [키워드] 24 hour acute phase acute respiratory distress Administered administration administration of methylprednisolone adverse effect adverse event adverse events affected age alveolar ARDS association benefit bone Cell chronic obstructive Clinical improvement clinical trial Complete consolidation contributed Corticosteroid COVID-19 COVID-19 complications COVID-19 disease criteria CRP level death decrease defined discharged distress dose doses download drug Efficacy ferritin figure glucocorticoid High dose high mortality rate High-dose Hypothesis immunomodulatory effect include Inclusion increased risk Infection Inflammatory marker inflammatory markers insight intravenous dose intubation large cohort lung male marker median median age median time Methylprednisolone MSC observational study one patient Organizing pneumonia outcomes PaCO2 paO2/fiO2 PaO2/FiO2 ratio parameter Patient patient survival patients died patients with COVID-19 PCO2 phase primary endpoint procalcitonin pulmonary disease Pulmonary infection Randomized controlled trial reactive reducing reported respiratory parameters SARS-CoV-2 second dose secondary endpoint secure Severe COVID-19 pneumonia severity STEM stem cell suggested syndrome therapeutic option therapy Thorax tissue treat treated Treatment Trial Two patient Ventilator-associated pneumonia worsening [DOI] 10.1182/blood-2021-154291 [Article Type] Conference abstract