The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal CellsCell and Developmental Biology Published on 2020-07-162022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Anti-inflammatory approach caused clinical study COVID-19 Demand Exosomes Extracellular vesicles heterogeneity Mesenchymal stromal cell MSC New patients with COVID-19 problem regenerative Research SARS-CoV-2 STEM stromal cell the cytokine storm therapeutic treat [DOI] 10.3389/fcell.2020.00645 PMC 바로가기 [Article Type] Cell and Developmental Biology
A Scoping Review of Registered Clinical Trials of Cellular Therapy for COVID-19 and a Framework for Accelerated Synthesis of Trial Evidence—FAST EvidenceReview article Published on 2020-07-012022-10-05 Journal: Transfusion Medicine Reviews [Category] SARS, 임상, [키워드] accelerated acute respiratory distress syndrome Admission Analysis anticipated appear approval ARDSacute respiratory distress syndrome candidate Cell cells cellular cellular therapy clinical clinical trial clinically complex conducted COVID-19 Critical cumulative detect determine effective Effectiveness enrolment framework heterogeneity ICUIntensive Care Unit identify implementation intensive care intensive care unit Intervention mechanical ventilation Mesenchymal stromal cell Meta-analysis Mortality MSC MSCmesenchymal stromal cell multiple study natural killer NK cells NKnatural killer outcome outcomes Patient predominant Prevent receive reductions in Registered registry Regulatory review Safe Sample size searched similar study stromal cell Study design subject subset Support synthesis therapy treat treatments for COVID-19 Trial while WHO [DOI] 10.1016/j.tmrv.2020.06.001 [Article Type] Review article
Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trialLetter Published on 2020-06-032022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 active malignancy acute respiratory distress syndrome Administered administration age approval approved ARDS assessment automated Berlin blinded Cell cell suspension cellular changes in chronic liver disease class clinical Clinical diagnosis Clinical outcome clinical outcomes clinical trial comparator Compliance conducted control group Controlled trial COVID 19 COVID-19 COVID-19 pandemic declined defined described determine diagnosis of COVID-19 dissemination Donor Dose escalation driving Effect Efficacy element eligible Elizabeth enrolled ethics committee EudraCT excluded facilitate failure fixed dose hospital ICU incidence Inclusion increase in index individual information infusion intensive care unit Intervention Invasive mechanical ventilation investigator King’s College London London Mesenchymal stem cells Mesenchymal stromal cells MHRA moderate Mortality MSC MSCs NIHR number objective open label Other outcome pandemic PaO participant Patient patient population patients with ARDS PCR test PF ratio Phase 1 Phase 2 Placebo placebo-controlled protocol protocol amendment Public randomised randomised controlled trial REC receiving recruited recruitment repair reported Research respiratory Resuscitation Sample size secondary Secondary objective Secondary outcomes Serious Adverse Events severe ARDS single intravenous infusion SOFA solution Standard steering committee stratified stromal cell Study protocol Therapeutics therapy trauma Treatment Trial triple blinded Trust umbilical United Kingdom university Venous Thromboembolism Ventilation verbal Volume web-based randomisation system website WHO Withdrawal [DOI] 10.1186/s13063-020-04416-w PMC 바로가기 [Article Type] Letter
Cell‐based therapy to reduce mortality from COVID ‐19: Systematic review and meta‐analysis of human studies on acute respiratory distress syndromeConcise Review Published on 2020-05-292022-10-28 Journal: Stem cells translational medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory distress syndrome adipose Administered adverse event Allogeneic alveolar ARDS Bone marrow Cell therapy clinical clinical study Combined comparison contribute COVID COVID‐19 COVID‐19 infection COVID‐19 cytokine cytokine production death determine edema Inflammatory inflammatory biomarker levels Injury intravenously literature review Lung compliance Macrophage membrane menstrual blood Mesenchymal stromal cells Mild modulate Mortality MSC MSC therapy MSCs nine PaO Participants patients with ARDS performed Potential treatment Pulmonary function Radiographic reduce mortality reduction remodeling processe reported resolved Serious Adverse Event shown statistical significance stromal cell syndrome systematic review T‐cell therapy tissue Trial umbilical variant yielding [DOI] 10.1002/sctm.20-0146 PMC 바로가기 [Article Type] Concise Review
The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome studySARS-CoV-2 수용체 ACE2 단일 세포 전사체 연구에 의한 모체-태아 경계면 및 태아 기관의 발현Research Article Published on 2020-04-162022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] abortion ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 caused Cell cell type cell types changed Characteristics Clinical practice collected coronavirus cytotrophoblast decidua diagnosed enzyme evaluate exhibited expressed expression fetal global public health human infection human infections investigated kidney liver lung mice Neonatal organ organs perivascular perivascular cells Placenta Pneumonia receptor respiratory SARS-CoV-2 SARS-CoV-2 receptor scRNA-seq severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-cell Single-cell RNA sequencing Spread stromal cell stromal cells the cell the SARS-CoV-2 Transcriptome Transmission vertical transmission virus WHO [DOI] 10.1371/journal.pone.0230295 PMC 바로가기 [Article Type] Research Article
Immunophenotyping of Sheep Paraffin-Embedded Peripheral Lymph NodesArticle Published on 2018-12-112023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] antibody confocal microscopy dendritic cell immunohistochemistry Lymph node macrophages sheep stromal cell [DOI] 10.3389/fimmu.2018.02892 PMC 바로가기