Differences in the Concentration of Anti-SARS-CoV-2 IgG Antibodies Post-COVID-19 Recovery or Post-VaccinationArticle Published on 2021-07-312022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] anti-SARS-CoV-2 IgG antibody Antibody titer blood sample cellular response Cohort Comirnaty Concentration COVID-19 difference eight subject enzyme-linked immunosorbent assays evaluate first dose greater healthy subject highest humoral humoral immune response Humoral response IgG IgG antibody individual individuals less levels of antibody marker mRNA vaccine mRNA-based vaccine Participants Patient Protective Regular second dose serological serological measurement seronegative seropositive significantly Spike protein symptomatic and asymptomatic T cell the S1 subunit vaccination was measured [DOI] 10.3390/cells10081952 PMC 바로가기 [Article Type] Article
Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection신경 혈관 단위의 세포에서 SARS-CoV-2 관련 수용체의 발현: HIV-1 감염에 대한 의미Research Published on 2021-07-292022-09-10 Journal: Journal of Neuroinflammation [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptors ADAM17 addition affected AGTR2 ANPEP Astrocyte astrocytes binding blood-brain barrier Brain brains BSG cathepsin B cathepsin L Cell cells claudin CNS co-expressed Complication complications of COVID-19 COVID-19 develop domain DPP4 Endothelial cell endothelial cells exposure to expression pattern help HIV-1 HIV-1 infection immunoblotting immunostaining implication infect infected cells investigated involved mechanism microglia cells microglial naïve Neurological complications Neurovascular pathway Patient protein expression Proteins qPCR receptor receptors responsible Result S protein S1 protein S1 subunit SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors subunit supplementary material the cells the S protein the S1 subunit tight junction TMPRSS2 TMPRSS2 expression Treatment upregulated virus entry while ZO-1 [DOI] 10.1186/s12974-021-02210-2 PMC 바로가기 [Article Type] Research
A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19Article Published on 2021-07-222022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome animal model binding coronavirus COVID-19 pandemic dose effective Efficacy elicited expresse expressing hamster Inflammation intranasal Live attenuated vaccines Lungs Neutralizing pathology produced PROTECT responsible SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S1 SARS-CoV-2 spike protein severe COVID-19 single dose single vaccine the S1 subunit Vaccine vesicular stomatitis virus viral replication virus replication VSV weight loss [DOI] 10.1038/s41541-021-00352-1 PMC 바로가기 [Article Type] Article
Antibody titres decline 3-month post-vaccination with BNT162b2항체 역가는 BNT162b2 백신 접종 3개월 후 감소Multicenter Study Published on 2021-07-222022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료법, [키워드] 95% CI All participants antibody Antibody Response baseline Blood BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine collected Concentration COVID-19 COVID-19 vaccine different time points dose first dose hcp Healthcare professional healthcare professionals humoral Humoral response individual Kinetics kinetics of antibody maximum concentration mRNA vaccine multicentre nucleocapsid Participants Receptor binding domain remained reported robust S1 subunit Sample SARS-CoV-2 SARS-CoV-2 nucleocapsid seronegative seronegative participants seropositive seropositive participants Spike protein subject subjects the antibody response the S1 subunit the SARS-CoV-2 the spike protein titre Vaccination strategy vaccine dose were measured [DOI] 10.1080/22221751.2021.1953403 PMC 바로가기 [Article Type] Multicenter Study
Laser-facilitated epicutaneous immunization of mice with SARS-CoV-2 spike protein induces antibodies inhibiting spike/ACE2 bindingSARS-CoV-2 스파이크 단백질을 사용한 마우스의 레이저 촉진 표피 면역화는 스파이크/ACE2 결합을 억제하는 항체를 유도합니다Article Published on 2021-07-222022-09-12 Journal: Vaccine [Category] MERS, SARS, 진단, [키워드] alternative route antibody BALB/c mice binding CpG danger-associated molecular patterns Epicutaneous immunization immunization induce inherent inhibit inhibiting Laser mice overcome Protein receptor ACE2 Recombinant spike protein respiratory virus SARS-CoV-2 SARS-CoV-2 spike protein serum IgG skin Skin micropores spike Spike protein subunit target tissue the S1 subunit the Spike the spike protein vaccination Vaccine [DOI] 10.1016/j.vaccine.2021.06.068 PMC 바로가기 [Article Type] Article
Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library사전 구조화된 DNA 라이브러리의 야생형 및 B.1.1.7 SARS-CoV-2 스파이크 단백질에 대한 다양한 고친화성 DNA 앱타머AcademicSubjects/SCI00010 Published on 2021-07-212022-09-10 Journal: Nucleic Acids Research [Category] SARS, 변종, 진단, 치료기술, [키워드] adopted affinity B.1.1.7 B.1.1.7 variant binding comparable COVID-19 diagnostic DNA DNA library DNA sequences enrichment exhibited experiment hairpin structure heat human saliva identify in vitro lentivirus limit of detection motif performed pool pseudotyped random S1 protein S1 subunit Saliva SARS-CoV-2 SARS-CoV-2 spike protein secondary secondary structure selection experiment selection pressure sequence Spike protein the S1 protein the S1 subunit the SARS-CoV-2 Trimeric spike protein were assessed wild-type wildtype [DOI] 10.1093/nar/gkab574 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Neutralising SARS-CoV-2 RBD-specific antibodies persist for at least six months independently of symptoms in adults Research Published on 2021-07-142022-10-05 Journal: Communications Medicine [Category] 진단, [키워드] acute respiratory syndrome All participant analysed Anosmia antibodies antibody antibody reactivity coronavirus detect detectable domain Europe evaluated IgA antibody IgG Immunoglobulin independent Large-scale testing neutralisation test neutralising antibody nucleocapsid protein pandemic Participants positive Post-infection RBD RBD-specific antibody reactive Result S1-reactive antibody SARS-CoV-2 SARS-CoV-2 RBD-specific antibody SARS-CoV-2-specific antibody sera Symptom Symptoms the S1 protein the S1 subunit the spike protein Virus neutralisation [DOI] 10.1038/s43856-021-00012-4 [Article Type] Research
Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study세르비아 북부의 SARS-COV-2 바이러스에 대한 항체의 혈청 유병률 (Vojvodina) : 4 연속 센티넬 인구 기반 조사 연구Research Article Published on 2021-07-092022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] 95% CI age anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Asymptomatic change conducted confirmed cases Course COVID-19 COVID-19 outbreak cross-sectional Gender IgG antibodies IgG antibody immunoassay immunochromatographic immunochromatographic test indicated Infection LINE monitoring no significant difference nucleocapsid protein point-of-care population prevalence public health qualitative test Rapid test rapid test) reached repeated Result RT-PCR S1 subunit SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 virus Seropositivity Seroprevalence significant difference Spike protein subgroup subject test results the S1 subunit the spike protein total population was tested were assessed widespread [DOI] 10.1371/journal.pone.0254516 PMC 바로가기 [Article Type] Research Article
A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronavirusesResearch Published on 2021-07-082022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] Antiviral component conducted coronavirus COVID-19 Diseases E. coli effective EK1 ELISA evaluate exhibited expressing GL25E glycan GRFT HCoV-229E HCoV-NL63 HCoV-OC43 HIV HR1 domain human coronavirus in vitro in vivo Infection inhibit inhibited inhibiting inhibitory inhibitory activity intranasally mechanism of action MERS-CoV mice mutants mutated Newborn Ni-NTA peptide performed Prevent previous study Prophylactic protective effect Protein Proteins pseudovirus purified Result S protein S2 subunit SARS-CoV SARS-CoV-2 SARS-COV-2 infection selected shown significantly more Spike protein the S1 subunit therapeutic treat were expressed wild-type [DOI] 10.1186/s13578-021-00638-w PMC 바로가기 [Article Type] Research
Dose-Related Aberrant Inhibition of Intracellular Perforin Expression by S1 Subunit of Spike Glycoprotein That Contains Receptor-Binding Domain from SARS-CoV-2Article Published on 2021-06-152022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Antigen presentation CD8+ T cell Cell correlation COVID-19 cytokine Cytokine storm syndrome cytotoxic activity cytotoxicity decrease dendritic cell dose dose-dependent explain explained expression feature functional help High dose Hypothesis immune response impairment in vitro Influenza inhibit inhibition interferon-γ Intracellular kill linear low dose Lymphocytes lymphoproliferation manifestation perforin persistence proinflammatory cytokines replicated response SARS-CoV-2 Seven Severe case shown significantly higher spike spike glycoprotein strain subsequent suppress suppressed the S1 subunit tumor necrosis factor-α Viral load virus [DOI] 10.3390/microorganisms9061303 PMC 바로가기 [Article Type] Article