the strongest – Page 6 – Communicable Diseases Research

Interferon-α2b Treatment for COVID-19 Is Associated with Improvements in Lung Abnormalities

COVID-19에 대한 인터페론-α2b 치료는 폐 이상 개선과 관련이 있습니다

Article

Published on 2020-12-302022-09-10
Journal: Viruses
[Category] MERS, SARS, 바이오마커, 치료제,

IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients

SARS-CoV-2에 대한 IgA2 항체는 중증 COVID-19 환자의 NET 형성 및 치명적인 결과와 상관 관계가 있습니다

Communication

Published on 2020-12-122022-09-11
Journal: Cells
[Category] MERS, SARS, 바이오마커, 진단,

[키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus Adaptive immune response anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody antibody level antibody levels C-reactive protein C-reactive protein (CRP characterized circulating contribute Control coronavirus correlated COVID-19 CRP level CRP levels extracellular DNA Formation Hospitalization Host ICU IgA IgA2 IgG response IgG responses Immune cell immune cells induce Infection Inflammation intensive care intensive care unit leads less marker mild symptoms moderate moderate symptoms NET neutrophil Neutrophil extracellular trap neutrophil extracellular trap (NET) organ injury outcome Patient patient groups patients plasma sample plasma samples respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2-infected patient SARS-CoV-2-infected patients SARS-CoV-2-specific IgG severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease severe SARS severe SARS-CoV-2 specific antibodies Spike protein Symptom the strongest These data TRAP were measured while
[DOI] 10.3390/cells9122676 PMC 바로가기 [Article Type] Communication

Epidemiological profile of SARS-CoV-2 among selected regions in Ghana: A cross-sectional retrospective study

가나의 일부 지역에서 SARS-CoV-2의 역학 프로파일: 단면 후향적 연구

Research Article

Published on 2020-12-102022-09-12
Journal: PLoS ONE
[Category] MERS, SARS, 진단,

[키워드] 95%CI age Analysis Anosmia association asymptomatic subject asymptomatic subjects average Chain Reaction Clinical presentations collected confirmation confirmed case conscious COVID-19 COVID-19 case COVID-19 cases cross-sectional deaths described epidemiological Features female females Gender greater highest individual Infection infection with SARS-CoV-2 IQR Laboratory majority male maximum middle minimum Ministry of Health Nasopharyngeal swab nasopharyngeal swabs pattern polymerase chain polymerase chain reaction presenting Prevalence professional provided Real-Time Reverse Transcription Polymerase Chain Reaction recorded reduction Region reproductive respiratory respiratory specimens Result Retrospective study reverse transcription reverse transcription polymerase chain reaction risk RT-PCR Saliva SARS-CoV-2 SARS-COV-2 infection selected socio-demographic specimen Spread sputum study population subject the disease the strongest trajectory Viral Viral load virus virus infection
[DOI] 10.1371/journal.pone.0243711 PMC 바로가기 [Article Type] Research Article

Disease control across urban–rural gradients

도시-농촌 구배에 걸친 질병 통제

1004

Published on 2020-12-092022-09-10
Journal: Journal of the Royal Society Interface
[Category] MERS, SARS, 치료기술, 치료제,

[키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 conditions connectivity Contact controlling coronavirus correlation disease disease control disease spread effective Efficacy Epidemic epidemiological metapopulation dynamics frequencies infected individuals initial Intervention Isolation local outbreak local outbreaks lockdown lockdowns measure Outbreaks pandemic control Population reduced reducing Region respiratory reversed SARS-CoV-2 severe acute respiratory syndrome Coronavirus source–sink dynamics Spread strength symptomatic case symptomatic cases symptomatic individual symptomatic individuals the strongest Transmission transmission rate transmission rates Travel urban populations
[DOI] 10.1098/rsif.2020.0775 PMC 바로가기 [Article Type] 1004

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

SARS-CoV-2 스파이크 단백질 변이체에 의한 중화 항체로부터의 탈출

Research Article

Published on 2020-10-282022-09-10
Journal: eLife
[Category] MERS, SARS, 변종, 진단,

[키워드] activate addressed Administered Analysis anti-SARS-CoV-2 antibodies antibody antibody combination antibody-based therapies antibody-based therapy Blood blood plasma cause Cell cells changed chimeric circulating Combination convalescent plasma coronavirus COVID-19 COVID19 creating effective vaccine Effective vaccines Effectiveness effort elicited eLife Epitopes escape evade Frequency functional Genome Health HIV host cells Human human cells human population human populations immune immune response immune system in some individual infect Infection Influenza kill Laboratory limit low frequencies maintain monoclonal antibodies monoclonal antibody mutant mutant virus mutate mutated Mutation N-terminal domain natural infection neutralize Neutralizing antibodies neutralizing antibody neutralizing epitopes New coronavirus Patient Population populations Prevent produced Prophylactic Proteins question RBD Receptor-binding domain Recovered COVID-19 patients reporter Research SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS-CoV-2 variant selected Sequencing Spike protein Spike proteins Structure structures target the antibody the disease the receptor-binding domain the SARS-CoV-2 the spike protein the strongest therapeutic Therapies treated Trigger vaccination Vaccine Vaccines variant Viral protein Viral proteins virus virus virus mutation virus particle virus particles viruses VSV were infected
[DOI] 10.7554/eLife.61312 PMC 바로가기 [Article Type] Research Article

COVID-19 symptoms predictive of healthcare workers’ SARS-CoV-2 PCR results

의료 종사자의 SARS-CoV-2 PCR 결과를 예측하는 COVID-19 증상

Research Article

Published on 2020-06-262022-08-13
Journal: PLoS ONE
[Category] COVID-19, Medicine and Health Sciences, MERS, SARS,

[키워드] 95% CI absence Accuracy Ageusia Anosmia Anosmia/ageusia assays Asymptomatic caused clinically contaminated surfaces coronavirus coronavirus 2019 disease COVID-19 COVID-19 symptom diagnostic Diagnostic accuracy disease exclusion Fever HCW HCWs healthcare healthcare worker Healthcare workers independent predictor initial less Loss of Smell loss of taste myalgia myalgias nasal nasal congestion nasopharyngeal Negative predictive value nine Patient performed positive Positive test Predictive Predictive value progression reported Retrospective study SARS-CoV-2 SARS-CoV-2 PCR sore throat Symptom Symptoms Taste temperature tested the strongest virus yielding
[DOI] 10.1371/journal.pone.0235460 PMC 바로가기 [Article Type] Research Article

Synaptogyrin-2 influences replication of Porcine circovirus 2

Synaptogyrin-2는 돼지 써코바이러스 2의 복제에 영향을 미칩니다

Research Article

Published on 2018-10-312022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Affect Amino acid Antigen association Author Cas9 Cell chromosome chromosome 7 clone complex conducted conserved CRISPR CRISPR-Cas9 disease disease susceptibility Diseases Dissection DNA virus domain Evidence evidence of ExoN explained expression General health Genetic genetic component genetic test genetic tests genetics Genome-wide association study genomic Genotype group of disease group of diseases growth Health Host host genetics hpi identification illnesses immune response immune system in viral incidence Infection influence involved leukocyte locus mammals Missense mutation Mutation Pathogenesis phenotypic phenotypic variance phenotypic variation PIGS polymorphism Population predict Protein provided proximal end QTL replicate Replication Research responsible RNA-sequencing severity sick single-stranded DNA SNP suggested supernatant susceptibility susceptible SYNGR2 the strongest underlie variant Variation Viral Viral load viral replication viral titer Viremia virus Welfare wildtype
[DOI] 10.1371/journal.pgen.1007750 PMC 바로가기 [Article Type] Research Article

Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia

GLS2의 인간 유전적 변이는 복잡한 황색 포도구균 균혈증의 발병과 관련이 있습니다

Research Article

Published on 2018-10-052022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activate age allele Analysis association Bacteremia Bacteria Bacterial Blood cells bloodstream Bonferroni correction candidate gene capture cause causes Cell coding variant complex Complication Control correlated CRISPR CRISPR-Cas9 cumulative cumulative effect death eight ENCODE evaluated examined exhibited Exome expression expression level Factor Frequency gene-based analysis gene-expression Genetic genetic factors genetic risk factor Genetic variant genetic variants Genetic variation Genome GLS2 Glutamine growth healthy controls Hospitalization Host Human Human genome immune response individual Infection infections Interaction key factor leukocyte leukocyte activation Logistic regression analysis Macrophage macrophage cells metabolism Microarray missense variant nitric oxide plasma concentration Protein regulate Regulatory Replication risk S . aureus sequence Sequencing Sex significantly significantly lower Staphylococcus aureus susceptible the strongest These cells Transcription variant variants Variation variations WES White blood cell White blood cells wild-type cells
[DOI] 10.1371/journal.pgen.1007667 PMC 바로가기 [Article Type] Research Article

High rate of adaptation of mammalian proteins that interact with Plasmodium and related parasites

Plasmodium 및 관련 기생충과 상호 작용하는 포유류 단백질의 높은 적응률

Research Article

Published on 2017-09-282022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] adaptation adaptive allele ancestor Bacterial infections Blood blood cell caused cell membrane cell protein conserved controls Critical critical organ curated disease domain domains driven by elevated Evidence Evolution expected explained expression Genetic genetic resistance genomes group Host host adaptation host gene host protein host proteins hosts Human genome human populations humans identify illness immune immune function infect Infection Infectious disease Interaction involved lack life cycle liver malaria mammal mammalian mammalian protein mammals many cases matched control matched controls non-immune organ outcome over parasite parasites pathogen Pathogens Plasmodium Plasmodium falciparum Pleiotropy Protein Proteins red blood cell relative representing second selective significantly spectrin Substitution susceptibility terrestrial the strongest title variety Viral
[DOI] 10.1371/journal.pgen.1007023 PMC 바로가기 [Article Type] Research Article

Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans

DARC 유전자좌(Duffy)의 인구 유전 분석은 인간의 말라리아 저항성과 관련된 변이로부터 적응을 보여줍니다

Research Article

Published on 2017-03-102022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 95% CI admixture African allele allelic Antigen antigen receptor Asia Asian association canonical causative agent Chemokine receptor chemokines Combination complex DARC disease Europe European example fixation Frequency gene encode genetic analysis Genome Haplotype haplotypes Human Human genome Human genomes human populations humans individual Infection Infectious diseases initial involved locus low frequency malaria membrane-bound mode Mutation observation parasite pathogen Pathogens Plasmodium vivax Population populations Positive selection PROTECT receptor red blood cell red blood cells Region reveal selective sequencing data shown signal sub-Saharan Africa subsequent the strongest the timing Variation
[DOI] 10.1371/journal.pgen.1006560 PMC 바로가기 [Article Type] Research Article