Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection
SARS-CoV-2 감염의 3가지 동물 모델에서 높은 예방 및 치료 효능을 가진 인간 항체의 신속한 식별
530
[키워드] Ab1
ACE2
ADCC
ADCC activity
Administered
aggregate
aggregation
animal model
animal models
antibody
antibody-dependent cellular cytotoxicity
Antigen
assays
BALB/c mice
binding
Combination
competition
Complete
Coronaviruses
COVID-19
Culture
dose
effective
Efficacy
elicited
exhibited
expressing
Fab
glycoprotein
hACE2
hamster
hamsters
human ACE2
human cell
human cell membrane
human monoclonal antibodies
Human monoclonal antibody
IgG1
in vitro
inhibited
lack
lowest
mAb
mAbs
mechanism
microbes
monoclonal
neutralization
neutralized
pandemic
Prophylactic
prophylactically
Prophylaxis
Protein
Proteins
public health threat
Rapid
RBD
Receptor binding domain
replication-competent SARS-CoV-2
SARS-CoV
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 infections
SARS-CoV-2 replication
SARS-CoV-2 spike
scFv
sequence
Significance
somatic mutations
tested
the SARS-CoV-2
therapeutic antibodies
therapeutic efficacy
therapy
tissue
tissue culture
transgenic mice
Vaccines
virus
virus infection
was selected
wild-type
[DOI] 10.1073/pnas.2010197117 PMC 바로가기 [Article Type] 530
[DOI] 10.1073/pnas.2010197117 PMC 바로가기 [Article Type] 530