The Tissue Renin-Angiotensin System and Its Role in the Pathogenesis of Major Human Diseases: Quo Vadis?Review Published on 2021-03-152022-10-31 Journal: Cells [Category] COVID-19, [키워드] AGTR1 angiotensin Angiotensin II Anti-inflammatory Autoimmune disease cardiovascular COVID-19 COVID-19 pandemic disease Effect highlight Human human diseases Inflammation Inflammatory interact intervertebral disc involved Major neuropathic Numerous Pain pathologic pathway Pathways Perspective positive pro-inflammatory progression Protective RAS receptor regeneration Regulatory renin-angiotensin renin-angiotensin system reported role SARS-CoV 2 senescence System therapeutic strategy this system tissue Treatment vulvodynia [DOI] 10.3390/cells10030650 PMC 바로가기 [Article Type] Review
A novel cell culture system modeling the SARS-CoV-2 life cycleSARS-CoV-2 수명 주기를 모델링한 새로운 세포 배양 시스템Research Article Published on 2021-03-122022-08-13 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agent Antiviral antivirals approach Author biosafety biosafety level BSL-2 BSL-2 laboratory BSL-3 can be used cause Cell Cell culture cell line cells chloride Complete coronavirus COVID-19 Critical Culture culture system Deletion dissect drug effective evidenced experimental system expresse expressing facilitate genetic recombination genetics genomic GFP global pandemic impede independent intein life cycle MERS MERS-CoV N monensin monensin sodium N gene N protein neutralization nucleocapsid Nucleocapsid gene Particles passage Phosphorylation powerful tool producer cells Protein Proteins replacing Replication replication-competent SARS-CoV-2 reporter reporter gene required Research residue respiratory Salinomycin SARS-CoV SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 N SARS-CoV-2 virus secure Sequence analysis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sodium the cells the N protein the SARS-CoV-2 this system trans Transcription vector vectors Viral viral genome viral infection viral life cycle Viral RNA virion assembly Virus life cycle [DOI] 10.1371/journal.ppat.1009439 PMC 바로가기 [Article Type] Research Article
Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck집 고양이에서 SARS-CoV-2의 전파는 좁은 병목 현상을 초래합니다Research Article Published on 2021-02-262022-08-13 Journal: PLoS Pathogens [Category] MERS, 변종, 유전자 메커니즘, 진단, [키워드] accelerated adaptive Amino acid amino acid position antigenic evolution arise bottleneck cats defined distribution escape event Evolution fixation fixed followed by Genetic genetic drift Genetic variation genomic H655Y Host hosts Human human monoclonal antibodies Human monoclonal antibody identify Infection intermediate frequency involved landscape mammalian mechanism model systems new infections new SARS-CoV-2 notable persist Positive selection reveal RNA virus SARS-CoV-2 SARS-CoV-2 consensus sequence SARS-CoV-2 consensus sequences SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus SARS-CoV-2 viruses scrutiny selected shown species spike Surveillance Therapeutics this system Transmission transmitted undergo Vaccine variant viruses [DOI] 10.1371/journal.ppat.1009373 PMC 바로가기 [Article Type] Research Article
A Versatile Reporter System To Monitor Virus-Infected Cells and Its Application to Dengue Virus and SARS-CoV-2바이러스 감염 세포를 모니터링하는 다목적 리포터 시스템과 뎅기열 바이러스 및 SARS-CoV-2에 대한 적용Article Published on 2021-01-282022-09-11 Journal: Journal of Virology [Category] 진단, 치료기술, [키워드] Antiviral antiviral activity Antiviral compounds application blocks can be used caused Cell cells characterization cleavage cleave Coronaviridae Coronaviruses Dengue dengue virus develop disease disease outbreaks disease severity effective etiological agent expressed Flaviviridae flexibility fluorescent fused GFP globe host cell human pathogen identify include infected cell infected cells Infection limit live cell imaging molecular nuclear nuclear translocation nucleoside nucleus outbreak pandemic Pathogens proof protease Protease activity Proteases Protein Quantitative reporter reporter cell lines reporter system Research RNA virus SARS-CoV-2 sequence severity Spread System the Coronaviridae these viruses this system translocate Viral viral proteases viral replication virus virus spread Virus-host interaction Virus-host interactions virus-infected cell virus-infected cells viruses Visualization Zika Zika virus [DOI] 10.1128/JVI.01715-20 PMC 바로가기 [Article Type] Article
A PCR amplicon-based SARS-CoV-2 replicon for antiviral evaluationArticle Published on 2021-01-262022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] Amplicon amplified Antimicrobials Antiviral Antiviral compound biosafety cell line control cell effective in vitro inhibited Laboratory Luminescence M gene Microbiology non-infectious PCR Remdesivir Replication replicon RNA RNA polymerase inhibitor robust Safe SARS-CoV-2 SARS-CoV-2 genome sequence the cell this system transcribed translation Viral RNA Virology [DOI] 10.1038/s41598-021-82055-0 PMC 바로가기 [Article Type] Article
Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week ProtocolCardiovascular Medicine Published on 2021-01-152022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 293T ACE2 addition adjuvants African approaches caused Cell cell line cells clinically coronavirus COVID-19 COVID-19 pandemic ENhance epithelial furin Generation GFP glycoprotein green high risk human ACE2 receptor human Calu-3 Infection infection assay knowledge Laboratory lack lentivirus lung epithelial mechanism Monkey neutralizing antibody non-human primate outcome over-expression overexpression Patient performed PGE2 poloxamer 407 producing prostaglandin E2 protease protocol pseudotyped viral particle pseudovirus Quantitative renal SARS-CoV-2 SARS-COV-2 infection spike the SARS-CoV-2 therapeutic Therapeutic approach this system TMPRSS2 VERO-E6 vesicular stomatitis virus viral entry viral infection virus VSV VSVΔG [DOI] 10.3389/fcvm.2020.618651 PMC 바로가기 [Article Type] Cardiovascular Medicine
Determining crucial genes associated with COVID-19 based on COPD Findings ✶,✶✶COPD 결과를 기반으로 COVID-19와 관련된 중요 유전자 결정 ✶,✶✶Article Published on 2021-01-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료기술, [키워드] analyzed CCR1 CD40LG cellular COPD COVID-19 COVID-19 virus dataset detect Determining disease FASLG finding function gene network gene networks GeneCard group ICAM1 immune system information IRF7 JUN LIFR MAPK8 MERS MOST NFkB1 NFKBIA organs pathway Patient patients POLD4 respiratory organs RPA2 SARS severe COVID-19 STAT2 susceptible the disease this system virus viruses was used with COVID-19 [DOI] 10.1016/j.compbiomed.2020.104126 PMC 바로가기 [Article Type] Article
Global Infectious Disease Surveillance and Case Tracking System for COVID-19: Development StudyOriginal Paper Published on 2020-12-222022-10-31 Journal: JMIR Medical Informatics [Category] COVID-19, [키워드] addition affected application Blockchain Care Case report caused center Control country COVID-19 COVID-19 defense development disease transmission Diseases drug treatments effective effort facilitate global public health Health Health authority health care systems help HL7 FHIR hospital include Infectious disease Infectious disease surveillance information interface international collaboration interoperability Intervention labor-intensive laboratory data mechanisms medications new virus objective outcome pandemic Patient patient data patients with COVID-19 physician Physicians prevent disease spread prevention PROTECT provide receive recorded Research researcher respond Result reuse Spread Support Surveillance Symptoms System the disease Therapies this system transferred Transmission Treatment Trial utility virus was used [DOI] 10.2196/20567 PMC 바로가기 [Article Type] Original Paper
mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2중증 급성 호흡기 증후군 코로나바이러스 2에 대한 적응 면역 반응 연구를 위해 쥐에서 mRNA 유도 인간 안지오텐신 전환 효소 2 발현Research Article Published on 2020-12-162022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Antigen Antiviral Author caused CD4+ CD4+ T cell CD8+ CD8+ T cell cells cloned coronavirus Critical demonstrated Efficacy entry of SARS-CoV-2 Epitopes expressed expression functional hACE2 hACE2 receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human coronavirus humans immune response in vivo induce Infection information interferon receptor Laboratory lack membrane Membrane proteins memory mice mRNA mRNA expression mRNA transfection mRNA-based murine murine model murine models nucleocapsid pandemic peptide peptide epitope peptides preserved provided receptor Replication required respiratory response SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pathogenesis Secondary infection severe acute respiratory syndrome Coronavirus Spike proteins strain T cell T cell epitope T cell epitopes T cell response T cells this system type 1 interferon unique Vaccine vaccine efficacy Vaccines virus [DOI] 10.1371/journal.ppat.1009163 PMC 바로가기 [Article Type] Research Article
Chest CT in COVID-19 at the ED: Validation of the COVID-19 Reporting and Data System (CO-RADS) and CT Severity Score A Prospective, Multicenter, Observational Study응급실에서 COVID-19의 흉부 CT: COVID-19 보고 및 데이터 시스템(CO-RADS) 및 CT 심각도 점수 A 전향적, 다기관, 관찰 연구Observational Study Published on 2020-11-302022-09-12 Journal: Chest [Category] SARS, 임상, 진단, [키워드] 30-Day mortality acute respiratory syndrome adjusted analyzed association AUC AUC, area under the curve calculated Chest CT CO-RADS, COVID-19 Reporting and Data System conducted coronavirus coronavirus disease correlation coefficient COVID-19 COVID-19, Coronavirus disease 2019 CT ctss CTSS, CT severity score CUSUM, cumulative sum control chart Cutoff Diagnosis diagnostic Diagnostic accuracy diagnostic workup emergency medicine evaluate Hospital admission ICU admission increase in introduced management MDT, multidisciplinary team of experts measure Netherland Netherlands NVvR, Radiological Society of the Netherlands Patient PCR PCR, polymerase chain reaction Pneumonia presenting Prognosis Prospective reported Reporting Result SARS-CoV-2 score sensitivity severity Society specificity Support System this system thought validation was performed WHO, World Health Organization [DOI] 10.1016/j.chest.2020.11.026 PMC 바로가기 [Article Type] Observational Study