CD8+ T cells specific to apoptosis-associated epitopes are expanded in patients with chronic HBV infection and fibrosisArticle Published on 2021-03-012023-06-13 Journal: Liver international : official journal of the Inte [Category] B형 간염, [키워드] Autoimmunity Chronic HBV infection fibrosis Treg [DOI] 10.1111/liv.14720
Phenotype, Susceptibility, Autoimmunity, and Immunotherapy Between Kawasaki Disease and Coronavirus Disease-19 Associated Multisystem Inflammatory Syndrome in Children소아에서 가와사키병과 코로나19 관련 다기관 염증 증후군 사이의 표현형, 감수성, 자가면역 및 면역요법Immunology Published on 2021-02-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, 변종, 진단, [키워드] addition ADE anti-cytokine antibody Antibody-dependent enhancement Antigen Atypical Autoimmune Autoimmunity Blood Group Cardiovascular events children Coagulopathy conditions convalescent stage coronavirus coronavirus disease Coronavirus disease-19 Corticosteroid Corticosteroids COVID-19 COVID-19 infection develop Diseases enemy Evolution FcγR Fever FOXP3 gastrointestinal symptoms genetic susceptibility Genetic variant growth factor HLA HLA-B HLA-DRB1 Host hosts human leukocyte antigen hyperinflammation identify IFNγ IL-10 IL-17A IL-6 Immunity Immunoglobulin Immunopathogenesis immunotherapies Immunotherapy Inflammatory interferon interleukin interleukin-6 Intravenous immunoglobulin IP-10 IVIG Kawasaki disease Know thyself lesions leukocyte locus lower expression Lymphadenopathy mass vaccination Mild MIS-C multisystem inflammatory syndrome in children pathogen Pathogenesis Patient phenotype Phenotypes physician physiological Precision PROTECT protective factor provided recognize regimen resulting reversal risk allele Severe COVID-19 Infection Shock shown signaling molecules similarity standard treatment Subtypes susceptibility susceptible Symptom syndrome T helper TGF-β Th17 the disease TLR Toll-like receptor transforming growth factor Treatment treatment regimen Treg vaccination Vasculitis [DOI] 10.3389/fimmu.2021.632890 PMC 바로가기 [Article Type] Immunology
The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2ACE2에 의해 지원되는 COVID-19 감염에서 JAK-STAT 신호 전달 경로의 잠재적 관련성Article Published on 2021-02-052022-09-11 Journal: Gene [Category] 유전자 메커니즘, [키워드] ACE2 Activation angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 B cells CD8 Cell coronavirus coronavirus disease correlation CoV infection COVID-19 COVID-19 infection downstream effective enzyme epithelial cells expected FOXP3 Gene Expression GSEA HAEs helper T cell helper T cells human airway epithelial human airway epithelial cells Immune cell immune response immunological indicated Infection investigated JAK-STAT signaling JAK-STAT signaling pathway macrophages mechanism nucleotide overactivation overexpressed pathway public health receptor regulate Regulatory reported respiratory SARS-CoV infection SARS-COV-2 infection Severe acute respiratory syndrome Signal-gene GSEA. similarity STAT T cell T cells Th1 cells Therapeutic strategies Treg [DOI] 10.1016/j.gene.2020.145325 PMC 바로가기 [Article Type] Article
Cytokine profile and disease severity in patients with COVID-19COVID-19 환자의 사이토카인 프로필 및 질병 중증도Article Published on 2021-01-012022-09-11 Journal: Cytokine [Category] 바이오마커, [키워드] (enzyme-linked immunosorbent assay age All participants Analysis ANOVA both groups can be used collected Concentration conducted control group controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokine dysregulation cytokine level cytokine levels Cytokines disease severity dysregulation ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluate healthy subject IFN-γ IL-17 IL-5 IL-8 IL-9 in both group infected with SARS-CoV-2 interferon interferon-γ interleukin involved mechanism Mild not differ one-way ANOVA participant Patient patients patients with COVID-19 Predictive proinflammatory responses serum Serum level serum levels serum sample serum samples severe group severity significant difference significant differences significantly significantly higher statistical analysis systemic tested TGF-β Th1 Th17 Treg was performed [DOI] 10.1016/j.cyto.2020.155323 PMC 바로가기 [Article Type] Article
Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progressionResearch Article Published on 2020-11-122022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] addition animal model antiviral response caused cell population changes in chemokine collected contribute COVID-19 COVID-19 progression Critical cytokine days post infection dissemination Epidemic GM-CSF IL-10 IL-15 IL-1β IL-4 IL-6 increases in Infection infection rate interstitial pneumonia Local local immune response Lower respiratory tract lung lung tissue lymph nodes MCP-1/CCL2 nasal natural infection observation parameter Pathogenesis pathogenesis of SARS-CoV-2 pathologic process pathological analysis PBMCs progression respiratory tract resulting rhesus SARS-CoV-2 SARS-COV-2 infection severe pneumonia Stool suggested suppressed T cell T cell response T cell subset the SARS-CoV-2 virus Treatment Treg understanding Vaccine Vaccine development Viral RNA virus [DOI] 10.1371/journal.ppat.1008949 PMC 바로가기 [Article Type] Research Article
Parameters predicting COVID-19-induced myocardial injury and mortalityArticle Published on 2020-11-012023-07-12 Journal: Life sciences [Category] SARS, [키워드] CD8 COVID-19 monocyte pericardial effusion SARS-CoV-2 Treg [DOI] 10.1016/j.lfs.2020.118400 PMC 바로가기
A potential role for cyclophosphamide in the mitigation of acute respiratory distress syndrome among patients with SARS-CoV-2SARS-CoV-2 환자의 급성 호흡 곤란 증후군 완화에서 사이클로포스파미드의 잠재적 역할Article Published on 2020-11-012022-09-12 Journal: Medical Hypotheses [Category] MERS, 진단, [키워드] acute respiratory distress approach ARDS Autoimmune diseases CCR5 Cell COVID Cyclophosphamide cytokine death deplete develop effective IL-6 immunological immunomodulator imperative investigated investigator less majority mitigate monoclonal antibodies monoclonal antibody patients with SARS-CoV-2 Population Pragmatic pro-inflammatory Regulatory T cell SARS-CoV-2 syndrome T cell the SARS-CoV-2 therapeutic strategy TNF-alpha Treg Tregs Vaccine while [DOI] 10.1016/j.mehy.2020.109850 PMC 바로가기 [Article Type] Article
Significant changes of CD4, FOXP3, CD25, and IL6 expression level in Iranian COVID-19 patientsOriginal Article Published on 2020-01-012022-10-31 Journal: Gastroenterology and Hepatology From Bed to Bench [Category] COVID-19, [키워드] Analysis blood sample CD25 CD4 cDNA synthesis change collected correlation COVID-19 COVID-19 patient distribution downregulated eight emerging disease evaluated Evaluating expression level expression profile FOXP3 healthy healthy control healthy controls hospitalized COVID-19 patients host immune responses IL-6 IL6 increase in indicated Inflammatory responses interleukin 6 marker patients Peripheral blood quantitative real-time PCR RNA SARS-CoV-2 severity of COVID-19 Significant significantly T cell the disease Total Treg was performed PMC 바로가기 [Article Type] Original Article
Treg/Th17 imbalance and its clinical significance in patients with hepatitis B-associated liver cirrhosisResearch Published on 2019-10-212023-06-03 Journal: Diagnostic Pathology [Category] B형 간염, [키워드] Hepatitis B-associated liver cirrhosis immune mechanism Th17 Treg [DOI] 10.1186/s13000-019-0891-4 PMC 바로가기 [Article Type] Research
Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly peopleResearch Published on 2019-07-052024-09-02 Journal: Immunity & Ageing : I & A [Category] 대상포진, [키워드] Inflammation Ki67 Thymic function TREC Treg [DOI] 10.1186/s12979-019-0154-y PMC 바로가기 [Article Type] Research