Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and OpportunitiesReview Published on 2020-11-052023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Angiogenesis Checkpoint inhibitor programmed death ligand 1 (PD-L1) programmed death-1 (PD-1) tumor microenvironment vascular endothelial growth factor (VEGF) [DOI] 10.3389/fimmu.2020.598877 PMC 바로가기 [Article Type] Review
COVID-19–Induced Modifications in the Tumor Microenvironment: Do They Affect Cancer Reawakening and Metastatic Relapse?Oncology Published on 2020-10-262022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] activate activated neutrophil Activation acute respiratory distress acute respiratory syndrome Anti-inflammatory Cancer cancer cell cause coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients DCC Disseminated tumor cells dormancy dormant Effect event generate Hypothesis Infection Inflammation innate immune response involved lung Lungs lymphopenia metastatic microenvironment monocytes/macrophages NETs neutrophil Neutrophil extracellular trap other organs patients with COVID-19 primary tumor pro-inflammatory cytokines pro-inflammatory factor produced proliferation promoted Relapse released resulting SARS-CoV-2 shown Support syndrome systemic inflammation therapy Treatment Tumor tumor cell tumor microenvironment tumor relapse [DOI] 10.3389/fonc.2020.592891 PMC 바로가기 [Article Type] Oncology
Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor Research Published on 2020-10-192022-10-05 Journal: Nature Genetics [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome amino acids angiotensin-converting enzyme 2 atlas binding cause cellular entry Co-infection condition coronavirus COVID-19 expression full-length SARS-CoV-2 independent induce Infection Inflammatory interferon-stimulated gene ISG isoform lack outcomes promote receptor SARS-CoV-2 Spike protein susceptibility target cells the SARS-CoV-2 transcriptionally Tumor tumor microenvironment unlikely Variability virus [DOI] 10.1038/s41588-020-00731-9 [Article Type] Research
Inflammation as a Driver of Prostate Cancer Metastasis and Therapeutic ResistanceReview Published on 2020-10-152022-10-31 Journal: Cancers [Category] COVID-19, [키워드] advanced disease Angiogenesis anoikis Aspirin association Bacterial Biomarker biomarker signature Cancer controls Critical cytokine disease Disease progression drug effective effector elevated EMT phenotype Evidence expression facilitate functional Genetic variation growth high mortality rate IL-6 Inflammation Inflammatory Inflammatory cytokine inhibitors lethal disease low dose macrophages malignancy men Metastasis metastatic disease Mortality mutagenic Occurrence Patient patients phenotypic Predictive primary tumor progression promote Prostate Prostate cancer reduce reduction in resistance resulting risk risk reduction simple Support survival survival signaling systemic impact TGF-β therapeutic therapy Treatment treatment resistance tumor microenvironment tumor relapse vascularity viral infections [DOI] 10.3390/cancers12102984 PMC 바로가기 [Article Type] Review
Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to TherapyReview Published on 2020-09-272023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] Immune checkpoint blockade immunotherapy response biomarker PD-L1 immune checkpoint PD-L1 regulation tumor microenvironment [DOI] 10.3390/ijms21197139 PMC 바로가기 [Article Type] Review
Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future PerspectivesReview Published on 2020-08-192023-08-30 Journal: Frontiers in Cell and Developmental Biology [Category] E형 간염, [키워드] Antiangiogenic therapy immunoregulation Immunotherapy tumor endothelial cells tumor microenvironment [DOI] 10.3389/fcell.2020.00766 PMC 바로가기 [Article Type] Review
ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19Article Published on 2020-07-152023-07-01 Journal: Journal for immunotherapy of cancer [Category] SARS, [키워드] Gene expression profiling Immunotherapy translational medical research tumor microenvironment [DOI] 10.1136/jitc-2020-001020 PMC 바로가기
The Multifaceted Roles of MSCs in the Tumor Microenvironment: Interactions With Immune Cells and Exploitation for TherapyReview Published on 2020-06-192023-08-30 Journal: Frontiers in Cell and Developmental Biology [Category] E형 간염, [키워드] Cancer Immunoediting immunosurveillance Inflammation Mesenchymal stromal cells Perinatal Placenta tumor microenvironment [DOI] 10.3389/fcell.2020.00447 PMC 바로가기 [Article Type] Review
Anti–PD-1/PD-L1 Blockade Immunotherapy Employed in Treating Hepatitis B Virus Infection–Related Advanced Hepatocellular Carcinoma: A Literature ReviewReview Published on 2020-05-282023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Hepatitis B virus Hepatocellular carcinoma Immunotherapy programmed cell death protein 1 programmed death-ligand 1 tumor microenvironment [DOI] 10.3389/fimmu.2020.01037 PMC 바로가기 [Article Type] Review
Role of Extracellular Matrix in Gastrointestinal Cancer-Associated AngiogenesisReview Published on 2020-05-232023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] Angiogenesis endothelial cells Extracellular matrix tumor microenvironment [DOI] 10.3390/ijms21103686 PMC 바로가기 [Article Type] Review