Natural products provide a new perspective for anti-complement treatment of severe COVID-19: a reviewReview Published on 2021-07-282022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] accounted Activation alleviate Anti-complement therapy Chinese chronic inflammation Coagulopathy complement Complement inhibitor contribute COVID-19 Critically ill Critically ill patient Cytokine storm drug resistance Efficacy Efficiency etiological hotspot immune response intravascular coagulation Mortality multiple organ failure natural natural products New organ dysfunction Perspective progressive respiratory failure reduction Regulation severity of COVID-19 Side effect supplementary material Symptom therapy Toxicity Treatment uncontrolled upstream with COVID-19 [DOI] 10.1186/s13020-021-00478-3 PMC 바로가기 [Article Type] Review
SARS-CoV-2: from its discovery to genome structure, transcription, and replicationReview Published on 2021-07-192022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] abundance ACE2 acute respiratory syndrome Atypical cleaved complex conducted contagious coronavirus COVID-19 COVID-19 pandemic Efficiency ENCODE exhibit expressing full-length function Genetic Genome genome structure genomic RNA gRNA infected cell infected cells Interaction isolates motif mRNA non-structural protein Nsp12 nsp13 Nsp9 ORF ORF1a ORF1b Pneumonia polyprotein positive-sense protease Proteins Replication respiratory virus responsible RNA RNA primer RNA synthesis RTC SARS-CoV-2 SARS-CoV-2 genome sgRNA sgRNAs single-stranded subgenomic RNA susceptible cell synthesis the SARS-CoV-2 genome TMPRSS2 Transcription transcription regulatory sequence translate translation TRS upstream Vesicle viral genome viral genome replication viral replication [DOI] 10.1186/s13578-021-00643-z PMC 바로가기 [Article Type] Review
Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine-Arginine-Alanine Variants in Coronavirus Disease 2019 Patients코로나바이러스 질병 2019 환자에서 프롤린-아르기닌-아르기닌-알라닌 변이체가 없는 박쥐 유사 중증 급성 호흡기 증후군 코로나바이러스 2의 자연 전염Article Published on 2021-07-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alanine arginine Chain Reaction cleavage Cluster Coronaviral coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 patients ENhance Evolution of SARS-CoV-2 Frequency furin furin cleavage PRRA motif hamster hamsters Human humans implication isolates motif Mutation natural natural infection organoids patients polymerase chain polymerase chain reaction Prevalence prevalence rate proline PRRA Quasispecies quasispecy respiratory S1/S2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Transmission transmitted upstream variant variants Vero VERO-E6 viral pathogenicity Viral variants virus wild-type zoonotic origin [DOI] 10.1093/cid/ciaa953 PMC 바로가기 [Article Type] Article
Perinatal health care access, childbirth concerns, and birthing decision-making among pregnant people in California during COVID-19Research Published on 2021-07-022022-10-28 Journal: BMC Pregnancy and Childbirth [Category] COVID-19, SARS, [키워드] black blunt California Care Childbirth Clinicians Community community transmission COVID-19 COVID-19 case COVID-19 infection COVID-19 pandemic Decision-making examined Financial insecurity Health healthcare healthcare access higher risk hospitalizations Impact individual infection rate morbidity Mortality outcome pandemic Perinatal Pregnancy pregnant public health Racial/ethnic minoritization researchers Result routine care SARS-CoV-2 shifting supplementary material Support targeting upstream [DOI] 10.1186/s12884-021-03942-y PMC 바로가기 [Article Type] Research
KEA3: improved kinase enrichment analysis via data integrationAcademicSubjects/SCI00010 Published on 2021-07-022022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, SARS, [키워드] cellular co-expression co-occurrence collected database enrichment enrichment analysis examined expected experiment experiments Gene Expression IMPROVE Interaction kinase Phosphoproteomics phosphorylated predict predicted Proteins proteomics responsible Signaling Small molecules substrate supported upstream [DOI] 10.1093/nar/gkab359 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Social Cohesion and Community Resilience During COVID-19 and Pandemics: A Rapid Scoping Review to Inform the United Nations Research Roadmap for COVID-19 RecoveryVI. Towards a Recovery from the COVID-19 Pandemic: UN Scoping Reviews Published on 2021-07-012022-10-30 Journal: International journal of health services : plannin [Category] COVID-19, MERS, SARS, [키워드] applicability cohesion Community Community resilience COVID-19 COVID-19 pandemic Disaster response event exacerbate framework Government Immediate include Local methodology National outcome Pandemics pillar Rapid Research response review social capital social cohesion stakeholder engagement understanding United Nation United Nations upstream women [DOI] 10.1177/0020731421997092 PMC 바로가기 [Article Type] VI. Towards a Recovery from the COVID-19 Pandemic: UN Scoping Reviews
COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1 + neutrophils and CD14 + monocytesCOVID-19와 RA는 PD-L1 + 호중구 및 CD14 + 단핵구를 구동하는 SPP1 골수성 경로를 공유합니다Research Article Published on 2021-06-182022-09-10 Journal: JCI Insight [Category] MERS, 바이오마커, [키워드] Activation alveoli appear Arthritis Autoimmune diseases BALF Bronchoalveolar lavage fluid cause CD14 CD48 Chronic inflammatory arthritis Cluster Concentration COVID-19 COVID-19 pathogenesis disease driven by FABP4 FCN1 hallmark healthy high plasma levels IHC Infectious disease Inflammation innate response intensive care unit investigation lung Macrophage macrophage cluster macrophage clusters macrophages mechanism mediators monocyte Monocytes myeloid cell neutrophil Neutrophils pathogenic pathology pathway PD-L1 plasma plasma concentrations Pneumonitis predicted Predictive predominant proinflammatory remained rheumatoid arthritis S100A12 severe COVID-19 severe pneumonia SPP1 synovial synovitis tissue trajectory transcriptionally transfer TREM2 unique upstream [DOI] 10.1172/jci.insight.147413 PMC 바로가기 [Article Type] Research Article
Severe COVID-19 pneumonia: Perfusion analysis in correlation with pulmonary embolism and vessel enlargement using dual-energy CT data중증 코로나19 폐렴: 이중 에너지 CT 데이터를 이용한 폐색전증 및 혈관 비대와의 상관관계 관류 분석Research Article Published on 2021-06-082022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] 8 women age Analysis analyzed Applying Cohort consecutive patient consolidation consolidations correlated correlation COVID-19 COVID-19 pneumonia demonstrated determine GGO help hypo Iodine lung marker men objective pathophysiology Patient Perfusion Pneumonia predominant Pulmonary embolism Result Severe COVID-19 pneumonia significantly significantly higher statistical analyses subset therapy upstream vessel was measured were used women [DOI] 10.1371/journal.pone.0252478 PMC 바로가기 [Article Type] Research Article
Extensive C->U transition biases in the genomes of a wide range of mammalian RNA viruses; potential associations with transcriptional mutations, damage- or host-mediated editing of viral RNAResearch Article Published on 2021-06-012022-10-29 Journal: PLoS Pathogens [Category] COVID-19, MERS, SARS, [키워드] accounted adaptive aligned ANOVA antiretroviral APOBEC association Caliciviridae change coding region Combination component contribute Coronaviridae dataset disease driven by Evidence Evolution Extensive fixation Flaviviridae Frequency Generation time genetic change Genome genome sequence genomes genomic HCV HIV-1 homoplasy identity infecting investigated mammalian mammals mechanism mechanisms multivariable analysis Mutation mutations Neutral Occurrence parameter phylogenetically provide random replicate Replication reported representing retrovirus RNA RNA secondary structure RNA virus RNA viruses SARS Coronavirus SARS-CoV-2 sequence sequence variability significantly subset Substitution thought transcriptional upstream Viral RNA virus while [DOI] 10.1371/journal.ppat.1009596 PMC 바로가기 [Article Type] Research Article
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection단백질체 분석은 RNA 헬리카제 DDX3X를 SARS-CoV-2 감염에 대한 숙주 표적으로 식별합니다.Article Published on 2021-06-012022-09-11 Journal: Antiviral Research [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료제, [키워드] accumulate aggregate antiviral drugs antiviral therapeutics cellular characterization COVID-19 cytoplasmic DDX3X DEAD RNA helicase develop eIF2α foci G3BP1 granules Health Helicase Host host protein host proteins Host-directed therapies identify infected cell infected cells infected Vero E6 cells Infection involved life cycle metabolism mitigate nucleoprotein Phosphorylation powerful tool Protein proteomic Proteomic analysis proteomics reduce Replication required ribonucleoprotein RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 replication scaffold proteins significantly small interfering RNAs small molecule Small molecules Stress stress granule stress granules Structure the SARS-CoV-2 Therapeutic strategies therapeutic strategy translation upstream Vero E6 VERO E6 cells Viral viral replication Viral RNA virus viruses [DOI] 10.1016/j.antiviral.2021.105064 PMC 바로가기 [Article Type] Article