Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike proteinSARS-CoV-2 스파이크 단백질의 돌연변이성 및 약물 가능성에 대한 알로스테릭 관점Article Published on 2022-04-072022-09-11 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] addition allosteric drugs allosteric effect allosteric effects allosteric effects of mutations Allostery binding characteristic determine diagnostics disease distal drug drug design druggability drugs Endemic Endemic disease escape mutation mechanisms mutability mutability. Mutation pandemic Perspective Protein recent RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 spike protein Signaling spike Spike protein the SARS-CoV-2 the spike protein Vaccine variants of concern Viral protein Viral proteins VoC VOCs while [DOI] 10.1016/j.str.2021.12.011 PMC 바로가기 [Article Type] Article
Molecular phylogeny of coronaviruses and host receptors among domestic and close-contact animals reveals subgenome-level conservation, crossover, and divergence국내 및 밀접 접촉 동물 사이의 코로나바이러스 및 숙주 수용체의 분자 계통 발생은 하위 게놈 수준의 보존, 교차 및 분기를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE2 ACE2 residue acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphacoronavirus alphacoronaviruses aminopeptidase N analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animals APN binding cathepsin L cattle Comparative Comparative phylogeny Complete conservation conserved Consistency coronavirus Coronavirus-2 Coronaviruses Critical cross determine dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 enzyme Enzymes events explain Factor furin furin cleavage furin cleavage motif genome sequence Genome sequences Host host receptor Host receptors hosts identify infecting intermediate host Intersection membrane MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular N protein N proteins nucleocapsid offer other coronavirus other coronaviruses Phylogenetic tree phylogenies Phylogeny polybasic Protein Protein binding Proteins receptor receptors Recombination respiratory syndrome coronavirus retained reveal S proteins S, E, M, and N proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SAS segregation sequence Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sialic acid similarities similarity spike Spike protein Support the S protein theory TMPRSS2 transmembrane serine protease transmembrane serine protease 2 unique Viral protein Viral proteins virus white-tailed deer β-coronavirus [DOI] 10.1186/s12917-022-03217-4 PMC 바로가기 [Article Type] Article
Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?Omicron: 최신 SARS-CoV-2 변종을 우려하게 만드는 요인은 무엇입니까?Review Published on 2022-03-232022-09-11 Journal: Journal of Virology [Category] SARS, 변종, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BA.1 BA.2 causative agent changes changes in concern coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta VOC Efficiency Evidence functional consequences Genome immune evasion less Mutation Neutralizing antibodies omicron pandemic pathogenic Protein resulting SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus South Africa spike Spike protein strain Transmission variants variants of concern Viral protein Viral proteins viral spike protein VoC VOCs [DOI] 10.1128/jvi.02077-21 PMC 바로가기 [Article Type] Review
A BioID-Derived Proximity Interactome for SARS-CoV-2 ProteinsSARS-CoV-2 단백질에 대한 BioID 파생 근접 상호작용체Article Published on 2022-03-152022-09-11 Journal: Viruses [Category] SARS, 신약개발, 유전자 메커니즘, [키워드] Analysis antiviral therapies antivirals assist association BioID caused Cell cells cellular cellular pathway COVID-19 COVID-19 pandemic drug library enrichment analysis expressing Follow-up Functional enrichment analyses Health Host host cell host cells human lung identify Interaction interactome labeling lung cancer mechanism Novel coronavirus novel coronavirus SARS-CoV-2 Pathogenesis Protein Proteins proteome proteomic proximity labeling. reported responsible SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 proteins SARS-CoV-2 viral the SARS-CoV-2 TurboID understanding valuable resource Viral proteins was used website [DOI] 10.3390/v14030611 PMC 바로가기 [Article Type] Article
Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening고처리량 스크리닝 적용을 위한 안정적인 SARS-CoV-2 레플리콘 시스템 구축Article Published on 2022-03-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral Antiviral effect antiviral effects Bacterial bacterial artificial chromosome biosafety level Biosafety Level 3 BSL2 BSL3 camostat Cell cell line cell lines cells chromosome compounds condition conditions coronavirus COVID-19 examined exhibited Favipiravir gene encoding In vitro infection inhibited interferon level 3 luciferase luciferase activity molnupiravir Neomycin Novel coronavirus Particles powerful tool produced RdRP RdRp inhibitor Remdesivir Renilla Renilla luciferase replicon reported RNA SARS-coronavirus SARS-coronavirus-2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sgRNA sgRNAs stable cell stable cell line suppressed the SARS-CoV-2 transient transfection transiently transfected Treatment VeroE6 cells Viral proteins viral replication [DOI] 10.1016/j.antiviral.2022.105268 PMC 바로가기 [Article Type] Article
Limited induction of SARS-CoV-2–specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19COVID-19에 비해 다기관 염증 증후군 아동에서 SARS-CoV-2-특이 T 세포 반응의 제한된 유도Research Article Published on 2022-02-222022-09-10 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] Adaptive immunity B cell responses CD4 CD8 Cellular immune response children contribute convalescent COVID-19 cytokine cytokine production cytokine response demonstrated develop full-length functional healthy controls Inflammatory Limited MIS-C mononuclear cell mononuclear cells nucleocapsid participant Pathogenesis peptides Peripheral blood Peripheral blood mononuclear cells plasma predominant quantified RBD Receptor binding domain responses against SARS-CoV-2 antigen SARS-COV-2 infection serologic Serologic response serologic responses significantly lower Spike receptor binding domain subset Support syndrome T cell T cell response T cell responses T cells Th1 Viral Viral proteins was reduced with COVID-19 [DOI] 10.1172/jci.insight.155145 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Infection Triggers Phosphorylation: Potential Target for Anti-COVID-19 TherapeuticsSARS-CoV-2 감염은 인산화를 유발합니다: Anti-COVID-19 치료제의 잠재적 표적Review Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] Affect AKT autophagy change COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Drug discovery EIF2AK2 elevated enzyme function GFR Host infected cells kinase kinases MAPK mutations Phosphorylation phosphorylation site PIKfyve PKC Potential potential therapeutic target potential therapeutic targets Protein regulate responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral SARS-CoV-2-infected cells Signaling signaling pathway signaling pathways specific inhibitor specific inhibitors survival target TGF-β Therapeutics Trigger triggers Viral proteins virus [DOI] 10.3389/fimmu.2022.829474 PMC 바로가기 [Article Type] Review
Lipid and Nucleocapsid N-Protein Accumulation in COVID-19 Patient Lung and Infected CellsCOVID-19 환자 폐 및 감염된 세포에서 지질 및 뉴클레오캡시드 N-단백질 축적Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료법, [키워드] accumulate accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused CD63 cell cultures cellular characterized Colocalization coronavirus COVID-19 COVID-19 patient COVID-19 patients cryo-section demonstrated effort electron microscopy explain fatal COVID-19 Final hallmark immune response indicate infected cell infected cells Infection Inflammatory response labeling last stage Lipid lipids Localization lung lung tissue marker Microscopy N-protein new virus nucleocapsid outbreak pandemic pathology Patient patients with COVID-19 processed Protein provoke Research respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus Still Structure subcellular localization the SARS-CoV-2 tissue tissues ultrastructure Vero Cell Vero cells Viral protein Viral proteins Visualization [DOI] 10.1128/spectrum.01271-21 PMC 바로가기 [Article Type] Research Article
Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodiesACE2 수용체 및 광범위 중화 항체의 SARS-CoV-2 Delta 변이체 인식을 위한 구조적 기반Article Published on 2022-02-152022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding ACE2 receptor affinity Antibody neutralization antigenic binding circulating complex conformational conformational state contribute cryo-EM Cryo-EM analysis cryo-EM structure cryo-EM structures Cryoelectron microscopy Delta delta variant destabilized dominant effective Engagement FIVE identify immune induce Interaction lead mAbs mechanism Mutation Neutralizing neutralizing antibody pathogenicity RBD RBM receptor SARS-CoV-2 sensitivity shedding Spread T478K tested Transmission Viral proteins [DOI] 10.1038/s41467-022-28528-w PMC 바로가기 [Article Type] Article
Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questionsSARS-CoV-2 뉴클레오캡시드 단백질에 의한 상 분리: 합의 및 미해결 질문Review Published on 2022-02-042022-09-10 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] biomolecular condensate ERGIC, ER-Golgi intermediate compartment experiment experiments function genomic RNA gRNA, genomic RNA highlight IDR, intrinsically disordered region Infection Innate immunity intrinsically disordered region lab MD, molecular dynamics membraneless organelle modulation N-protein N, nucleocapsid nucleocapsid nucleocapsid protein observation organelle overlapping performed phase phase separation Protein PS, phase separation question required resource RNA RNP, ribonucleoprotein SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 pandemic stress granule the SARS-CoV-2 undergo Viral Viral protein Viral proteins viral replication virus viruses [DOI] 10.1016/j.jbc.2022.101677 PMC 바로가기 [Article Type] Review