A new SARS-CoV-2 variant with high lethality poorly detected by RT-PCR on nasopharyngeal samples: an observational study비인두 샘플에 대한 RT-PCR로 잘 검출되지 않는 높은 치사율을 지닌 새로운 SARS-CoV-2 변종: 관찰 연구Observational Study Published on 2022-02-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, [키워드] 28-day mortality 95%CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed anti-SARS-CoV-2 Characteristics chest CT scan clinical collected coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections Coronavirus infections/epidemiology Coronavirus infections/virology COVID-19 COVID-19 case COVID-19 cases Cox model enrolled feature hospital Inclusion inclusion criteria Inpatient interquartile range involved IQR Lineage Lower respiratory tract lower respiratory tract samples multivariable nasopharyngeal nasopharyngeal sample Nasopharyngeal samples new SARS-CoV-2 nosocomial Older outbreak outcome Patient positive radiological respiratory sample RT-PCR RT-PCR test RT-PCR tests SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 variants Sequencing Seroconversion severe disease severity of illness severity of illness index Symptom the WHO variant Virological Virology VoC WGS whole-genome sequencing [DOI] 10.1016/j.cmi.2021.09.035 PMC 바로가기 [Article Type] Observational Study
Longitudinal, virological, and serological assessment of hospitalized COVID-19 patients입원한 COVID-19 환자의 종단, 바이러스 및 혈청학적 평가Article Published on 2022-02-012022-09-11 Journal: Journal of Neurovirology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Admission anal swabs anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 IgM Antibody titers Blood blood sample Blood samples Cohort collected COVID-19 pandemic COVID-19 patient COVID-19 patients described discharge ELISA evaluated Evidence First wave healthcare Hospital admission Hospitalized hospitalized COVID-19 patient IgG antibody titer IgG antibody titers IgG levels IgM and IgG implication Italy longitudinal median time nasopharyngeal nasopharyngeal swabs Negative conversion NPs Patient patients positive provide qRT-PCR RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA detection serological assessment seropositive serum sample serum samples significantly Swab tested the median Virological [DOI] 10.1007/s13365-021-01029-0 PMC 바로가기 [Article Type] Article
Demographic, Virological Characteristics and Prognosis of Asymptomatic COVID-19 Patients in South ChinaMedicine Published on 2022-01-282022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] age ALT Asymptomatic Asymptomatic case asymptomatic patients B.1 B.1.1 B.1.1.7 B.1.351 B.6 Characteristics China chronic liver disease Community Comorbidity country COVID-19 COVID-19 patient demographic develop Epidemiology Genotype Guangdong Hospitalization Hospitalized hypertension infected cases information Laboratory less Lineage lymphocyte Negative conversion Patient patients PCT Prognosis Region Result RNA SARS-CoV-2 SARS-CoV-2 RNA significantly South Subtypes symptomatic Symptomatic patients the SARS-CoV-2 Total Transmission turn variant variants Virological virus WBC [DOI] 10.3389/fmed.2022.830942 PMC 바로가기 [Article Type] Medicine
Biomedical Potential of the Neglected Molluscivorous and Vermivorous Conus SpeciesReview Published on 2022-01-272022-10-30 Journal: Marine Drugs [Category] Coronavirus, SARS, [키워드] Conus Andaman Islands biomedical compounds Biomedical research candidate categories coast Conotoxin Conus correlation demonstrated distribution map Drug discovery Evolution exhibited explicit feeding habit functional highlight highlighting hotspot include malaria therapy multi Neglected Neogene observation Perspective pharmaceutical Phylogenetic relationship Phylogenetic tree Potential promote receive Reclaiming Research resource SARS-CoV-2 Specy urgency Virological warm worm worms [DOI] 10.3390/md20020105 PMC 바로가기 [Article Type] Review
Genomic and Virological Characterization of SARS-CoV-2 Variants in a Subset of Unvaccinated and Vaccinated U.S. Military PersonnelMedicine Published on 2022-01-272022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] analyzed approved characterization characterized circulating clinical sample Cohort collected complicate COVID-19 pandemic Delta delta variant Effectiveness effort emerging SARS-CoV-2 variants genomic Healthcare system imperative increase in Increasing Isolation MONITOR nasal swab nasal swabs Next-generation sequencing other variant other variants PCR positive sample predominant provide qRT-PCR quantification Quantitative real time SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 variant Sequencing study population subset Surveillance unique United State vaccine breakthrough infection Vaccines variant variants viable virus viral shedding Virological virus [DOI] 10.3389/fmed.2021.836658 PMC 바로가기 [Article Type] Medicine
Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 교차 변형 중화 사이트 매핑Coronaviruses Published on 2022-01-242022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses antibody approved B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 bind binding biochemical Combination comparable conserved coronavirus cryo-EM decrease effective vaccine Efficacy epitope Epitopes evaluate exhibit exhibits Guidance identify loop mAbs mapping monoclonal antibodies monoclonal antibody neutralization neutralize Neutralizing potency pseudoviruses raised RBD Receptor-binding domain receptor-binding motif respiratory SARS-CoV-2 SARS-CoV-2 spike protein SD1 significantly Spike protein target tested the receptor-binding domain the SARS-CoV-2 the spike protein therapeutic Therapies Vaccine variant variants variants of concern Virological [DOI] 10.1080/22221751.2021.2024455 PMC 바로가기 [Article Type] Coronaviruses
Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies경증 또는 중등도 형태의 COVID-19 환자에서 스파이크 유전자 진화 및 면역 탈출 돌연변이 및 모노클로 날 항체 요법으로 치료Brief Report Published on 2022-01-242022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] administration anti-spike monoclonal antibodies anti-spike monoclonal antibody bamlanivimab clinical impact COVID-19 escape etesevimab Evolution form immune escape mutation Immunosuppressed immunosuppressed patients mAb mAbs Mild mixture moderate molecular molecular evolution monoclonal antibodies therapy Mutation outcomes Patient patients treated performed Q493R receiving SARS-CoV-2 spike spike gene two patients Virological [DOI] 10.3390/v14020226 PMC 바로가기 [Article Type] Brief Report
Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variantSARS-CoV-2 Delta 변종으로 인한 대규모 발병의 바이러스 감염 및 전파Article Published on 2022-01-242022-09-10 Journal: Nature Communications [Category] SARS, 변종, [키워드] average caused China Daily Delta delta variant early infection epidemic wave Epidemiology Evidence faster greater highlighting index case indicated individual Infection infections Intra-host variant intra-host variants iSNV Lineage lineages Local outbreak pandemic PCR testing PCR-positive replicate SARS-CoV-2 Spread Substitution the SARS-CoV-2 Transmission Viral viral infection Viral load viral loads viral replication virion Virological [DOI] 10.1038/s41467-022-28089-y PMC 바로가기 [Article Type] Article
Virological and Serological Characterisation of SARS-CoV-2 Infections Diagnosed After mRNA BNT162b2 Vaccination Between December 2020 and March 2021Medicine Published on 2022-01-202022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] activity analysed Analysis anti-nucleoprotein Breakthrough infection characterisation Characteristics Clinical course clinical feature Clinical features collected conducted coronavirus disease Course COVID-19 COVID-19 pandemic defined Diagnosis dose effective evaluated events feature Gamma genomic hospitalisation immunological individual Infection Infectious disease Isolation Italy Lazio less majority measure median Mild MOST mRNA BNT162b2 mRNA BNT162b2 vaccine NAb neutralise Neutralising Antibodies NPs NPSs occurred Patient pauci/asymptomatic Post-vaccine proportion Protein RBD receiving Region reported Result Rome SARS-CoV-2 SARS-CoV-2 variant serological serum serum sample significantly single dose spike statistically significant Substitution Surveillance Swab Symptom symptomatic case titre vaccination Vaccine vaccine breakthrough infections vaccine dose vaccinees variant variants Viral load Viral variants Virological [DOI] 10.3389/fmed.2021.815870 PMC 바로가기 [Article Type] Medicine
SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cellsSARS-CoV-2 Omicron 변이체는 TMPRSS2 발현 세포에서 Delta 변이체와 비교할 때 복제 및 융합 활성이 덜 효율적입니다.Comparative Study Published on 2022-01-192022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] Affect Antiviral effect B.1.1.529 bafilomycin Calu3 CaLu3 cells camostat Cell cell line cells Characteristics Chloroquine clinical manifestation clinical manifestations competition Delta delta variant Delta variants disease severity Endocytic pathway entry pathway Immune escape Infection inhibit inhibited inhibiting less mutations not enhanced omicron Omicron variant replicated Replication robust SARS-CoV-2 Serine TMPRSS2 TMPRSS2 expression TMPRSS2 pathway transmembrane serine protease transmembrane serine protease 2 Transmissibility variant variants viral replication Virological [DOI] 10.1080/22221751.2021.2023329 PMC 바로가기 [Article Type] Comparative Study