SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in TissuesSARS-CoV-2는 수지상 세포를 손상시키고 조직에서 DC-SIGN 유전자 발현을 조절합니다Article Published on 2021-08-262022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] ACE2 airway ANXA1 Blood CD22 cDCs coronavirus SARS-CoV-2 COVID-19 COVID-19 patient COVID-19 patients dataset DC-SIGN DCs dendritic cell dendritic cells downregulation Gene Expression healthy controls host receptor Host receptors immature immune responses indicate innate immune response innate immune responses L-SIGN lung lung DC Lungs MHCII Mild modulation observation pathogenic pDCs plasmacytoid DC plasmacytoid DCs provide SARS Coronavirus SARS coronaviruses SARS-CoV-2 screened Severe case severe cases severe COVID-19 SIGN Single Cell stimulate transcriptomic upper airway [DOI] 10.3390/ijms22179228 PMC 바로가기 [Article Type] Article
Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responsesArticle Published on 2021-08-252022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] activated Cell Cell Biology cell lines Comparative Computational biology and bioinformatics COVID-19 disease Critical disease status Diseases Endoplasmic reticulum Express expression level hACE2 HEK293T cell Host Host immune response human Angiotensin-converting enzyme immune attack immune response immune responses immunology infected cell Infection Infection route innate immune response mechanism Microbiology model system Molecular biology overexpress Pathogenesis pathway progression Protein provided reflect reveal robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell severity of COVID-19 Stress Systems biology Transcriptome transcriptomic analysis triggering Viral load virus [DOI] 10.1038/s41598-021-96462-w PMC 바로가기 [Article Type] Article
Biomarkers and Immune Repertoire Metrics Identified by Peripheral Blood Transcriptomic Sequencing Reveal the Pathogenesis of COVID-19말초 혈액 전사체 시퀀싱으로 식별된 바이오마커 및 면역 레퍼토리 메트릭은 COVID-19의 발병 원인을 밝힙니다Immunology Published on 2021-08-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] acute infection acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alteration Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 IgG B-cell response Biomarker Biomarkers caused change Clustering Cohort contribute convalescent convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 declined Effective vaccines facilitate feature FIVE gene expression profile Gene expression profiles help Host immune response Identified IgG immune immune responses increased expression independent Infection Inflammation machine learning Metrics molecular mechanism molecule nervous system pandemic Pathogenesis pathogenesis of COVID-19 Patient performed peripheral Peripheral blood positively correlated Post-infection predict Reinfection repertoire respiratory RNA sequencing SARS-CoV-2 SARS-COV-2 infection Serum level severe acute respiratory syndrome Coronavirus severe symptoms significantly T-cell T-cell Response therapeutic strategy transcriptomic characteristics UCHL1 [DOI] 10.3389/fimmu.2021.677025 PMC 바로가기 [Article Type] Immunology
Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease호산구의 행동은 질병 과정에서 회복되고 사망 한 Covid-9 환자에서 수수료를받습니다.Article Published on 2021-08-242022-09-01 Journal: Viruses [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Behavior clinical symptom Clinical symptoms coronavirus coronavirus disease Coronavirus disease 2019 count Course COVID-19 COVID-19 patients Day death Deceased disease Eosinopenia eosinophil Eosinophil count eosinophil counts eosinophils exacerbated greater Hospitalization immune response immune responses implication Infection Inflammation leukocyte leukocytes lymphocyte negative correlation neutrophil neutrophil count neutrophil counts Neutrophil-to-lymphocyte ratio Neutrophils NLR outcome pathology Patient patients proportion recovered recovered patient recovered patients respiratory retrospective cohort study SARS-CoV-2 severe acute respiratory syndrome Coronavirus survival rate the disease white blood cell differential counts [DOI] 10.3390/v13091675 PMC 바로가기 [Article Type] Article
Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patientsSARS-COV-2 항-스파이크 단백질 RBD IgG의 비교 동역학 및 BNT162B2 mRNA 백신 대 COVID-19 환자의 회복기 및 순진한 수용자에서 중화 항체의 비교 동역학Comparative Study Published on 2021-08-232022-09-01 Journal: BMC Medicine [Category] MERS, SARS, 진단, [키워드] Abstract Anti-S-RBD IgGs Anti-spike Antibody titer Antibody titers Antigen BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine BNT162b2 vaccine causative agent caused Cellular immune response clone Cohort Comparative contribute convalescent coronavirus COVID-19 COVID-19 patient COVID-19 recovered patient COVID-19 recovered patients dose global pandemic healthy Hospitalized hospitalized patient hospitalized patients humoral Humoral and cellular immune responses IgG IgGs immune immune response immune responses Immunity induce investigated moderate moderate disease moderate or severe disease mononuclear cells NAb NAbs naïve natural infection Neutralizing antibodies neutralizing antibody offer participant Peripheral blood Peripheral blood mononuclear cells priming priming vaccination promote Protein RBD IgG RBD IgGs recipient recipients response Result robust SARS-CoV-2 serum severe COVID-19 severe disease significantly higher supplementary material Support T cell titers Trigger triggers vaccinated individual vaccinated individuals vaccination vaccination efficacy Vaccine viral infection virus infection were measured [DOI] 10.1186/s12916-021-02090-6 PMC 바로가기 [Article Type] Comparative Study
Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2Review Published on 2021-08-232022-10-30 Journal: The Journal of Venomous Animals and Toxins Including Tropical Diseases [Category] COVID-19, [키워드] ACE2 Cell cell metabolism Clinical symptoms consequence COVID-19 pandemic Cytokine storm cytosol detect DNA Effect enrolment example hidden Host host cell immune immune responses innate receptors Interaction lung mechanism Mitochondria mitochondrial Mitochondrial function Pathogenesis Pathways Proinflammatory response receptor replicative respond robust SARS-CoV-2 signaling pathway the disease therapeutic interventions viral infection virus [DOI] 10.1590/1678-9199-JVATITD-2020-0183 PMC 바로가기 [Article Type] Review
Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives안티 코로나 바이러스 및 면역 조절 페놀 화합물 : 기회 및 약물 치료 적 관점Review Published on 2021-08-232022-09-01 Journal: Biomolecules [Category] 진단, 치료제, [키워드] acute respiratory syndrome coronavirus antiviral drug antiviral drugs applicability cardiovascular caused chalcone Comorbidities COVID-19 COVID-19 patients diabetes disease dual dysregulated immune response dysregulated immune responses effective flavonoid high mortality rate immune response immune responses immunomodulatory activities kidney Kidney diseases MERS-CoV Middle East Respiratory Syndrome Virus modulation natural phenolic compound natural phenolic compounds natural products Novel coronavirus opportunity patients with comorbidity Perspective pharmacological Pharmacotherapeutic plants respiratory Respiratory disease SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe respiratory disease shown systemic inflammation therapeutic strategy viruses [DOI] 10.3390/biom11081254 PMC 바로가기 [Article Type] Review
Health care worker seromonitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration의료 종사자 혈청 모니터링은 일반적인 코로나 바이러스 항체와 COVID-19 증상 기간 사이의 복잡한 관계를 보여줍니다Research Article Published on 2021-08-232022-09-10 Journal: JCI Insight [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Adaptive immunity antibody Antibody titer Antibody titers Betacoronavirus CCV Cellular immune response Cohort collected complex coronavirus COVID-19 COVID-19 severity COVID-19 symptom cross-reactive antibodies cross-reactive antibody duration of symptom elicited Health care Health care worker health care workers Hypothesis identify immune responses immunology individual Infection infections limit mechanism reduce reduced reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Serological assay serological assays significantly symptom duration [DOI] 10.1172/jci.insight.150449 PMC 바로가기 [Article Type] Research Article
The microbiota-related coinfections in COVID-19 patients: a real challengeReview Published on 2021-08-212022-10-28 Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19, [키워드] acute respiratory syndrome adaptive immune system Black fungus Coinfection Community coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 transmission diagnose Ebola Epidemics global pandemic Health highlight immune responses Immunity immunocompromised individuals Infection Infection transmission Infectious disease internal and external involved Local Lungs MERS microbiota nasal passages Pandemics pathogenic Pathogens pathological conditions pathology Patient Proinflammatory cytokine public health reported Resident microflora salivary gland SARS-CoV-2 severity the disease therapy treat Zika [DOI] 10.1186/s43088-021-00134-7 PMC 바로가기 [Article Type] Review
Adaptive Immunity and the Risk of Autoreactivity in COVID-19COVID-19의 적응 면역 및 자가반응 위험Review Published on 2021-08-202022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] adaptive affecting antigens association autoantibodies Autoimmune disease Autoimmune diseases Autoimmunity autoreactivity Complication COVID-19 COVID-19 patients disease exacerbate expressed Immune cell immune cells immune responses immune system Immunity Infection insight lupus erythematosus mechanism molecular mimicry multiple organs multiple sclerosis Occurrence Pathogens Pathologies PROTECT reported respiratory infection respond response responses SARS-CoV-2 SARS-COV-2 infection self-antigens Side effect Side effects SLE systemic lupus erythematosus target the disease viral infections while [DOI] 10.3390/ijms22168965 PMC 바로가기 [Article Type] Review