RNA sequencing-based analysis of the spleen transcriptome following infectious bronchitis virus infection of chickens selected for different mannose-binding lectin serum concentrationsResearch Article Published on 2016-01-272022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Activation adaptive Adaptive immune response Analysis bronchitis caused chicken Concentration contagious coronavirus DE gene Differential gene expression differentially expressed disease euthanized expression expression profile Gene ontology Genes GO term IBV IBV infection immune immune response Immunity Immunoglobulin improvement Infection Infectious bronchitis Infectious Bronchitis Virus Interaction involved leukocyte mannose-binding lectin molecular mechanism post infection Process proliferation Recombination Regulation Result RNA RNA sequencing selected serum significant difference spleen subset supplementary material System T cell T cell activation Transcriptome understanding uninfected was performed were infected were used [DOI] 10.1186/s12864-016-2403-1 PMC 바로가기 [Article Type] Research Article
Lipid lowering efficacy and safety of Ezetimibe combined with rosuvastatin compared with titrating rosuvastatin monotherapy in HIV-positive patientsHIV 양성 환자에서 로수바스타틴 적정 단독요법과 비교한 에제티미브와 로수바스타틴 병용요법의 지질강하 효능 및 안전성Research Published on 2015-06-192022-09-06 Journal: Lipids in Health and Disease [Category] Communicable Disease, [키워드] addition AIP ALT Antiretroviral therapy API apoA1 ApoB Apolipoprotein B appear AST baseline characteristics C-reactive protein change Characteristics cholesterol clinical symptom Clinical symptoms clinical trial Combination combination treatment develop dose dyslipidemia dyslipidemias Efficacy Efficacy and safety eligible examined Ezetimibe group groups guideline HDL-C High-density lipoprotein High-density lipoprotein cholesterol High-sensitivity C-reactive protein HIV HIV-infected patient HIV-infected patients hsCRP improvement increase in LDL-C Lipid lipid profile Low-density lipoprotein Low-Density Lipoprotein cholesterol Mild minimum monotherapy myalgias not differ Open-label parameter Patient patients with HIV percentage plasma Primary outcome Randomized Result Rosuvastatin Safe Significant statin targets therapy Total cholesterol Transport treatment groups Trial Triglyceride two patients [DOI] 10.1186/s12944-015-0054-x PMC 바로가기 [Article Type] Research
Serological assays for emerging coronaviruses: Challenges and pitfallsArticle Published on 2014-03-232022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] acute respiratory syndrome addition Analysis antibody Antibody detection Antigen applicability applied challenge common cold conserved Contact coronavirus CoV CoV spike protein CoVs cross-reactive antibody cross-reactivity Diagnosis diagnostic diagnostics Epidemic epitope highlight IMPROVE improvement infected individual information Isolation less majority MERS MERS-coronavirus MERS-CoV Middle East multiple method Novel viruses Nucleic acid detection nucleocapsid protein Nucleocapsid proteins occur occurred Occurrence outbreak problem public health authorities reported researcher reservoir reservoirs SARS-coronavirus SARS-CoV Sensitivity and specificity sera serological Serological assay Serological testing serology Spike protein Spread subsequent syndrome tested variety viral antigens [DOI] 10.1016/j.virusres.2014.03.018 PMC 바로가기 [Article Type] Article
SWIFT: Prospective 48-Week Study to Evaluate Efficacy and Safety of Switching to Emtricitabine/Tenofovir From Lamivudine/Abacavir in Virologically Suppressed HIV-1 Infected Patients on a Boosted Protease Inhibitor Containing Antiretroviral RegimenSWIFT: 항레트로바이러스 요법을 포함하는 강화된 프로테아제 억제제를 사용하는 바이러스학적으로 억제된 HIV-1 감염 환자에서 라미부딘/아바카비르에서 엠트리시타빈/테노포비어로 전환하는 것의 효능 및 안전성을 평가하기 위한 전향적 48주 연구HIV/AIDS Published on 2013-06-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 3TC/ABC 95% confidence interval abacavir addition Arm ARMS backbone baseline characteristics calculated CD4 Characteristics cholesterol compared Containing Decline decrease Decreased defined Efficacy and safety EGFR emtricitabine emtricitabine/tenofovir epidermal epidermal growth factor evaluate FTC/TDF fumarate GFR greater growth factor HIV patient HIV patients HIV-1 Human immunodeficiency virus immunodeficiency virus improvement Improvements Infected inhibitor lamivudine LDL Lipid lipids Lipoproteins Low-density lipoprotein low-density lipoproteins male median median age nucleoside Open-label parameter Patient PI primary endpoint Prospective Protease inhibitor Randomized rebound receiving receptor regimen reverse transcriptase risk score Ritonavir RNA RTV Safety study drug subject suppressed switch switching tenofovir disoproxil fumarate TG The United States threshold Total cholesterol transcriptase treated treatment difference Triglyceride triglycerides United States virologic failure Virologic suppression [DOI] 10.1093/cid/cis1203 PMC 바로가기 [Article Type] HIV/AIDS