Reduced numbers of T cells and B cells correlates with persistent SARS-CoV-2 presence in non-severe COVID-19 patientsArticle Published on 2020-10-192022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 치료기술, [키워드] adaptive Adaptive immunity age analyzed B cell CD3 CD4 clinically collected comparable COVID-19 COVID-19 patient demonstrated disease onset healthy controls healthy subject healthy subjects hospital Immune cell immune cells Infectious diseases Laboratory laboratory data lymphocyte subpopulation Microbiology monitoring NK cell non-severe patient Patient patients persistent positive Recovered COVID-19 patients recruited reduced SARS-CoV-2 significantly higher significantly increased T cell T cells the SARS-CoV-2 transferred university Wuhan [DOI] 10.1038/s41598-020-73955-8 PMC 바로가기 [Article Type] Article
Impact of COVID-19 lockdown on flash and real-time glucose sensor users with type 1 diabetes in England영국의 제1형 당뇨병이 있는 플래시 및 실시간 포도당 센서 사용자에 대한 COVID-19 잠금의 영향Observational Study Published on 2020-10-162022-09-01 Journal: Acta Diabetologica [Category] MERS, SARS, 임상, 진단, [키워드] Affect analysed baseline changes in coefficient Coefficient of variation Cohort collected Consensus COVID-19 COVID-19 lockdown diabete diabetes England evaluate Flash glucose monitoring Glucose Impact International lockdown Metrics outcome outcomes Patient platform positive proportion Real-time continuous glucose monitoring required Result Self-management sensor significantly increased significantly lower Support T1D T1D patient Type 1 diabetes Variation [DOI] 10.1007/s00592-020-01614-5 PMC 바로가기 [Article Type] Observational Study
Elevated Exhaustion Levels of NK and CD8 + T Cells as Indicators for Progression and Prognosis of COVID-19 DiseaseCOVID-19 질병의 진행 및 예후 지표로서의 NK 및 CD8 + T 세포의 고갈 수준 증가Immunology Published on 2020-10-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] (PD-1) acute respiratory syndrome coronavirus analyzed association Blood CD16 CD244 CD3 CD4 CD56 CD8 Cell cell population Characteristics circulating Clinical data collected contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient Critical Critical illness cytokine Cytokines demographic disease disease severity dysregulation effector molecule elevated eliminating enrolled evaluated Exhaustion expression flow cytometry functional IL-10 IL-6 immune dysregulation immune system IMPROVE Indicator infected cells Level Logistic regression logistic regression model lymphocyte Lymphocyte subset Lymphocyte subsets natural killer natural killer (NK) cells NK cell NK cells NKT cell NKT cells Pathogenesis Patient patients with COVID-19 PD-1 percentage percentages perforin phenotypic predict Prognosis progression public health reduced Regulatory respiratory Result risk factor Risk factors SARS-CoV-2 screened serum Serum IL-6 Serum level serum levels severe acute respiratory syndrome coronavirus 2 Severe case severe cases severe COVID-19 patients severe patients severe symptoms severity of COVID-19 significantly significantly increased subset T cell T cells TNF-α Union Hospital virus Wuhan [DOI] 10.3389/fimmu.2020.580237 PMC 바로가기 [Article Type] Immunology
Natural Language Processing Reveals Vulnerable Mental Health Support Groups and Heightened Health Anxiety on Reddit During COVID-19: Observational StudyOriginal Paper Published on 2020-10-122022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, MERS, SARS, [키워드] ADHD analyses Analysis analyzed Anxiety applied baseline borderline personality disorder categories category changes in Cluster Clustering COVID-19 COVID-19 pandemic demonstrated disorder disorders distribution eating disorders event Evidence feature group groups Health help impacted independent individual infodemic infodemiology infoveillance initial language less loneliness mental health mental health problem natural natural language processing objective pandemic Posttraumatic Stress problem processing psychiatry real time Reddit released resource Result significantly significantly increased social media spike Suicidality Support Topic unique utility website [DOI] 10.2196/22635 PMC 바로가기 [Article Type] Original Paper
A whole blood test to measure SARS-CoV-2-specific response in COVID-19 patientsOriginal Article Published on 2020-10-102022-10-04 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단, [키워드] Abstract Activation Antigen approach characterized CMV COVID-19 COVID-19 patient diagnostic diagnostic test disease endothelial Enterotoxin evaluated expressed FGF fibroblast G-CSF GM-CSF granulocyte-colony stimulating factor growth factor IFN-γ IFN-γ IL-10 IL-12p70 IL-13 IL-15 IL-17A IL-1ra IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 Image immune response individual inflammatory protein interferon IP-10 Macrophage MCP-1 median MIP-1β monocyte chemoattractant protein-1 Multiplex analysis Necrosis objective parameters Patient PDGF peptide platelet-derived growth factor Protein RANTES regulated Result SARS-CoV-2 SARS-CoV-2 peptide SEB secreted Serology response significantly increased Specific response T cell T-cell T-cell based tests Th1 Th2 TNF-α Vaccine Vascular VEGF Whole blood with COVID-19 [DOI] 10.1016/j.cmi.2020.09.051 PMC 바로가기 [Article Type] Original Article
Nutrition Behaviors in Polish Adults before and during COVID-19 LockdownArticle Published on 2020-10-102022-10-30 Journal: Nutrients [Category] Coronavirus, MERS, SARS, [키워드] Adults alcohol average Behavior between meal changes changes in condition conducted COVID-19 decrease eating habits food consumption Isolation less lockdown majority nutrition participant question questionnaire reduced reported selected Significant significantly significantly increased social distancing social isolation sweet women [DOI] 10.3390/nu12103084 PMC 바로가기 [Article Type] Article
Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)Cardiovascular Medicine Published on 2020-10-092022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] ACE inhibitors adjusted age ARB ARBs association Cardiomyopathy cardiovascular cardiovascular disease cohort study cohorts Comorbidities Comorbidity contribute Coronavirus disease 2019 COVID 19 COVID-19 Data analysis death Deceased discharged Effect higher risk highest hospital Hospitalization hypertension increased the risk indicate initial Inpatient Inpatients Italian Italy linear logistic regression model majority male medication Mortality number of comorbidities number of comorbidity Older older population outcome patients populations positive proportion random effect reported risk risk of death Safe Sex significantly significantly increased suffered the disease [DOI] 10.3389/fcvm.2020.585866 PMC 바로가기 [Article Type] Cardiovascular Medicine
The Role of Dentists in COVID-19 Is Beyond Dentistry: Voluntary Medical Engagements and Future PreparednessMedicine Published on 2020-10-062022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] addition Care changed clinician Community competency Course COVID-19 COVID-19 pandemic dental dentist dentistry Engagement example Future greater Healthcare system include infection control knowledge Laboratory novel coronavirus SARS-CoV-2 outbreak pandemic Perspective physician positive preparedness professionals Research resource role School significantly increased similarities Singapore surgical swabbing voluntary voluntary work Volunteer [DOI] 10.3389/fmed.2020.00566 PMC 바로가기 [Article Type] Medicine
Impact of COVID-19Quarantine on Low Back Pain Intensity, Prevalence, and Associated Risk Factors among Adult Citizens Residing in Riyadh (Saudi Arabia): A Cross-Sectional StudyArticle Published on 2020-10-062022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] back back pain body mass index composed coronavirus disease COVID-19 cross-sectional demographic characteristics Factor females genders Impact individual intensity LBP low back pain male Musculoskeletal Pain participated physical activity Prevalence quarantine question questionnaire recommendations reported risk factor Risk factors Saudi Arabia significant difference significant increase significantly higher significantly increased Stress was used [DOI] 10.3390/ijerph17197302 PMC 바로가기 [Article Type] Article
Dynamic Panel Surveillance of COVID-19 Transmission in the United States to Inform Health Policy: Observational Statistical StudyOriginal Paper Published on 2020-10-052022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] Administered Analysis applied approach cause census changes in Combination Contagion Contamination COVID-19 COVID-19 cases COVID-19 transmission declines deficiency dependent on driven by dynamic estimate Evolution generate Government Health policy increase in Infection Intensive Measurement error Metrics models National objective occur operationalization pandemic Panel parameter persistence Positive test provide public health Region remained reopening reopening America required Result Safe SARS-CoV-2 SARS-CoV-2 infections significantly increased Spread Static statistical statistical model subject Surveillance sustained Test the United State Transmission Transmission model United State Validity variety virus [DOI] 10.2196/21955 PMC 바로가기 [Article Type] Original Paper