Compartmentalized Replication of SARS-Cov-2 in Upper vs. Lower Respiratory Tract Assessed by Whole Genome Quasispecies AnalysisArticle Published on 2020-08-262022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Analysis analyzed approach Bioinformatic clade Clustering collected coronavirus COVID-19 COVID-19 patients diagnosed Evolution Frequency genetic heterogeneity Genome heterogeneous identify intensive care unit Intra-host variability Ion Italy Lower Lower respiratory tract LRT NGS no significant difference nucleotide Patient patients Quasispecies quasispecy respiratory SARS-CoV-2 Sequencing Strains supported Thermofisher tract upper URT Variability variant virus replication was performed whole-genome [DOI] 10.3390/microorganisms8091302 PMC 바로가기 [Article Type] Article
Test performance evaluation of SARS-CoV-2 serological assaysArticle Published on 2020-08-062022-10-04 Journal: Nature biotechnology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] affected anti-SARS-CoV-2 IgM antibody Appropriate assessment Asymptomatic conducted detect ELISAs enzyme-linked immunosorbent assay head-to-head evaluation heterogeneous IgG antibody IgM Immunity Infection Informed Interpretation lateral flow mechanism mild infection peaking POC point-of-care polymerase chain protective immunity public health SARS-CoV-2 SARS-CoV-2 infections serological Serological assay serological test serology seropositive individual severe disease specificity specimens subset symptom onset Test tested threshold time interval Variability [DOI] 10.1038/s41587-020-0659-0 PMC 바로가기 [Article Type] Article
Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2Article Published on 2020-08-022022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] ACE-2 affecting AhR Air pollution Analysis angiotensin-converting enzyme 2 Aryl hydrocarbon receptor association Bioinformatic bioinformatic analysis cell receptor cellular response Concentration Consensus contributing to correlation Correlation analysis COVID-19 DNA sequence environmental factor epidemiological data evaluate fatality Fatality rate favor geographical areas Health human airway Hypothesis identify incidence inter-individual Involvement Italian mechanism mortality rate motif nine outcome over-expression pandemic PM2.5 relation risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection severity Spread Support the SARS-CoV-2 transcription factor Variability was performed xenobiotic response element [DOI] 10.3390/ijerph17155573 PMC 바로가기 [Article Type] Article
Comparison of diagnostic accuracies of rapid serological tests and ELISA to molecular diagnostics in patients with suspected coronavirus disease 2019 presenting to the hospitalComparative Study Published on 2020-08-012022-10-06 Journal: Clinical microbiology and infection : the official [Category] SARS, 진단, [키워드] 95% CI Accuracy acute respiratory syndrome Analysis C-reactive protein (CRP Characteristics Cohort coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRP diagnostic diagnostics disease eligible ELISA evaluated heterogeneous hospital immunochromatographic assay individual Lateral lateral flow lateral flow immunoassay molecular NAT NATs nucleic acid amplification Orient Patient patient control group patients plasma sample presenting Rapid rapid serological test Rapid test respiratory sample respiratory symptom SARS-CoV-2 sensitivity sera serology severe acute respiratory syndrome coronavirus 2 specificity Symptom Symptoms Test Variability [DOI] 10.1016/j.cmi.2020.05.028 PMC 바로가기 [Article Type] Comparative Study
Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populationsArticle Published on 2020-07-312022-10-31 Journal: Genes and Immunity [Category] COVID-19, MERS, [키워드] ACE2 African angiotensin-converting enzyme 2 applied COVID-19 disease entry of SARS-CoV-2 eQTL expression Factor functional Genetic genetic determinant Genetic predisposition glycoprotein host cell host cell membranes host genetics individual individuals inter-individual lower expression mechanism Population populations Quantitative receptor SARS-CoV-2 serine protease TMPRSS2 severity of COVID-19 susceptibility the SARS-CoV-2 TMPRSS2 TMPRSS2 expression Variability viral entry viral spike [DOI] 10.1038/s41435-020-0107-7 PMC 바로가기 [Article Type] Article
A negative covariation between toxoplasmosis and CoVID-19 with alternative interpretationsArticle Published on 2020-07-272022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Analysis antiviral effects appear applied autocorrelation BCG vaccination carried country covariation disease Diseases Effect Effects Epidemics Factor GDP Human hygiene Immune-mediated indirect effects Interaction Interpretation introduced mammal measure Microbial ecology morbidity morbidity and mortality Mortality MOST Observational data pandemic Pandemics Parasitology Pathogens pregnant women Prevalence question Result statistical Structure susceptibility toxoplasmosis Variability [DOI] 10.1038/s41598-020-69351-x PMC 바로가기 [Article Type] Article
Exploring Urological Experience in the COVID-19 Outbreak: American Confederation of Urology (CAU) SurveyOriginal Article Published on 2020-07-272022-10-29 Journal: International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology [Category] COVID-19, SARS, [키워드] addressed America Cancer Care Clinical Management Protocol conducted COVID-19 COVID-19 diagnostic testing [Supplementary Concept] COVID-19 outbreak COVID-19 pandemic Cystectomy disease English experience Factor Health healthcare heterogeneity Hospitalization implementation implication indication infected with COVID-19 Inpatient Italian knowledge Latin management management protocol material nephrectomy North America outpatients Patient performed PPE priority protocol protocols question Radical reported response Safe South America Spanish statistical analyses surgical Surgical Procedures, Operative survey urgency Urology Variability website [DOI] 10.1590/S1677-5538.IBJU.2020.S119 PMC 바로가기 [Article Type] Original Article
Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort StudyArticle Published on 2020-07-232022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] all age group analyzed Asymptomatic Cohort Control coronavirus 2 Coronavirus disease 2019 COVID-19 Ct value cycle cycle threshold Cycle threshold values evaluate follow-up period HCW HCWs health care workers healthcare worker Infection Length median time N genes onset of symptom positive positive individual positive individuals profile public health emergency Rapid respiratory Result returned reverse transcription PCR RT-PCR SARS-CoV-2 Spread Swab symptomatic tested the SARS-CoV-2 time value Variability Variation with COVID-19 worker [DOI] 10.3390/ijerph17155313 PMC 바로가기 [Article Type] Article
Identification and Analysis of Unstructured, Linear B-Cell Epitopes in SARS-CoV-2 Virion Proteins for Vaccine DevelopmentArticle Published on 2020-07-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] B-cell B-cell epitope B-cell epitopes bat coronavirus Consensus coronavirus COVID-19 cross-protection development Efficacy epitope Epitope prediction epitope switch event facilitate humans identification immune system immunoinformatics intermediate lack linear mutational processe N proteins nucleic acid-based vaccine overlap pandemic predictor previous study Protein reported SARS-CoV SARS-CoV-2 SARS-CoV-2 isolate secondary structure serum Stage Strains switching transfer translated unfolded protein response Vaccine Variability while zone [DOI] 10.3390/vaccines8030397 PMC 바로가기 [Article Type] Article
Issues for the management of people with diabetes and COVID-19 in ICUReview Published on 2020-07-202022-10-31 Journal: Cardiovascular Diabetology [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome Biomarkers cardiovascular complications cells coronavirus COVID-19 Critical D-dimer diabete diabetes Diabetes, Intensive Care Unit evaluated Evidence expression Glucose glycemic glycemic control high risk hyperglycemia hypoglycemia ICU ICU admission IMPROVE inhibitors insulin intensive care unit intravenous issue management outcome pandemic penetrate Prevent receptor SARS-CoV-2 significantly suggested Variability [DOI] 10.1186/s12933-020-01089-2 PMC 바로가기 [Article Type] Review