Starvation, Together with the SOS Response, Mediates High Biofilm-Specific Tolerance to the Fluoroquinolone Ofloxacin기아는 SOS 반응과 함께 Fluoroquinolone Ofloxacin에 대한 높은 생물막 특정 내성을 매개합니다Research Article Published on 2013-01-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a minor age Amino acid amino acids antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial biofilm carbon carbon source Community Concentration Critical demonstrated dependent on Escherichia coli exhibited functional greater growth hallmark heterogeneity heterogeneous Hypothesis identify infections influence lead leucine Medical devices microenvironment minor molecular mechanism molecular mechanisms multicellular Mutagenesis mutant mutants ofloxacin organism physiological physiological state planktonic random response significantly SOS SOS response starvation Stress stress response subpopulation subpopulations Support systemic infections Tolerance transposon [DOI] 10.1371/journal.pgen.1003144 PMC 바로가기 [Article Type] Research Article
Virus Pathogen Database and Analysis Resource (ViPR): A Comprehensive Bioinformatics Database and Analysis Resource for the Coronavirus Research CommunityArticle Published on 2012-11-192022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] 3D Structures Analysis analysis annotation annotations bioinformatics Community Comparative genomics Comprehensive Coronaviridae Coronaviridae family coronavirus database diagnostics Epitopes facilitate genomes Host immune Multiple sequence alignment pathogen Pathogens Phylogenetic phylogenetic inference Protein provide Record reference genome related viruses Research respiratory returned SARS SARS-CoV sequence sequence variation severe statistical analysis structures Support the Coronaviridae transfer Vaccine virus virus [DOI] 10.3390/v4113209 PMC 바로가기 [Article Type] Article
Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic StrategiesReview Published on 2012-11-122022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome aluminum antiseptic antiseptics-disinfectants Antiviral treatment approach Betacoronavirus biological fluids bronchitis children common cold Coronaviridae family coronavirus coronavirus described development different Efficacy emerging disease environmental condition environmental survival evaluate found HCoV 229E high risk HKU1 hospital Human human coronavirus human coronaviruses humans immunosuppressed patients Infection infections infective influence insight involved knowledge lack led to management mean methodology Neonates New NL63 nosocomial OC43 outbreak pathogen pathogenicity Pneumonia Prevent resistance respiratory diseases responsible RNA virus SARS-CoV specific treatment specificity Spread Strategy Support surgical temperature the Coronaviridae upper respiratory tract viral infections viruses [DOI] 10.3390/v4113044 PMC 바로가기 [Article Type] Review
Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal TractsResearch Article Published on 2012-04-302022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] ACE2 activate Activation Cell culture coexpressed conserved expressed found Gastrointestinal Host hosts Human human host human respiratory tract human tissues in viral in viral spread Infected Influenza influenza virus Influenza virus influenza viruses Multiple Pathogenesis protease receptor respiratory SARS-coronavirus Site Support target cell TMPRSS2 tract transmembrane serine protease viral spread vocal folds [DOI] 10.1371/journal.pone.0035876 PMC 바로가기 [Article Type] Research Article
SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatusSREBP는 인간 곰팡이 병원체 Aspergillus fumigatus에서 트리아졸 약물 및 저산소증 반응을 중재하기 위해 철과 에르고스테롤 항상성을 조정합니다Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A. fumigatus acquisition activated adaptation Adding addition advance Aspergillus fumigatus Author binding Candida albican Candida albicans caused cellular response class clinically condition conditions Coordinate Critical Cryptococcus neoforman Cryptococcus neoformans decrease dependent on drug drug susceptibility drugs ergosterol eukaryotes found foundation fungal fungal infections fungal pathogen Gene Genetic growth growth defect Health Human hypoxia hypoxic identify immunocompromised condition infections initial involved iron iron homeostasis Iron metabolism led to lethal disease majority mechanism metabolism microenvironment Most patients mRNA mutant mutants pathogenic Pathogens Patient phenotype Protein regulate Regulation regulatory element required response restoration Sterol Support susceptibility susceptible These data transcription factor transcription factors triazole virulence [DOI] 10.1371/journal.pgen.1002374 PMC 바로가기 [Article Type] Research Article
Comparative and Functional Genomics of Rhodococcus opacus PD630 for Biofuels Development바이오연료 개발을 위한 Rhodococcus opacus PD630의 비교 및 기능 유전체학Research Article Published on 2011-09-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accurate Actinomycetale Analysis approach assigned Author Bacteria bacterium Biofuel carbon catabolic cellular Comparative Comparative analysis Complete compounds conserved development dry weight Engineering Enzymes eukaryotic Fatty acid fatty acids Gene gene family Genetic Genome genome sequence Genomics growth homologous homologous genes identify implicated included information led to lipid metabolism metabolic product metabolism multidisciplinary approach Pathways performed phenotypic phenotypic information Phylogenetic analysis predicted gene provide provided reaction related Research screened sequenced substrate substrates Support target gene Target genes triacylglycerol working model [DOI] 10.1371/journal.pgen.1002219 PMC 바로가기 [Article Type] Research Article
Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus InfectionResearch Article Published on 2010-01-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 2B4 cell 2B4 cells Activation aggravate antiviral genes antiviral signaling bronchial bronchial epithelial cell calu-3 cells cellular cloned complementary complex coronavirus detected detrimental dynamic epithelial epithelial cell line event expression found functional growth highlight Host Human identify IFN-stimulated gene IFN-β IFN-λ Immune-mediated Infected Inflammatory cytokine Inflammatory mediators Inflammatory responses Innate interferon interferon regulatory factor ISGs limit lung epithelial cell Lungs nuclear pathology post infection Protein Replication respiratory response resulting SARS pathogenesis SARS-CoV SARS-CoV infection secreting severe Signaling Support target these cell triggered [DOI] 10.1371/journal.pone.0008729 PMC 바로가기 [Article Type] Research Article
Differential stepwise evolution of SARS coronavirus functional proteins in different host speciesResearch Article Published on 2009-03-052022-10-28 Journal: BMC Evolutionary Biology [Category] Coronavirus, [키워드] adaptive addition Amino acid Analysis bat bats China different Epidemic etiological agent events Evolution found functional protein group Host hosts Human Hypothesis indicated introduced late phase NO pathway patients Positive selection Previous studies previous study Protein representing Result SARS Coronavirus SARS-CoV SARS-like-CoV selective Stage Support target the spike protein wet market [DOI] 10.1186/1471-2148-9-52 PMC 바로가기 [Article Type] Research Article
Plaque assay for human coronavirus NL63 using human colon carcinoma cellsMethodology Published on 2008-11-122022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] African green monkey Antiviral Avicel carboxymethyl-cellulose Cell Cell culture colds Colon coronavirus cytopathogenic effect days post infection demonstrated different disease Drug screening Effects HCoV HCoV-NL63 Human human pathogen humans Infection kidney log NL63 plaque Plaque assay plaque assays produced purification quantification replicated Result Support susceptibility tested utility viral infectivity virus virus infectivity virus replication virus stock [DOI] 10.1186/1743-422X-5-138 PMC 바로가기 [Article Type] Methodology
Broadening of Neutralization Activity to Directly Block a Dominant Antibody-Driven SARS-Coronavirus Evolution PathwayResearch Article Published on 2008-11-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 80R activity amino acid change analysis Anti-viral Anti-viral therapy Author block caused CDR Combination complementarity determining region component Cytidine deaminase dominant driving effective elicited Epidemic epitope escape mutant escape mutants escape mutation Evidence Evolution found generate human convalescent sera immune immune pressure IMPROVE Infected Infectious disease information introduced investigated Mutagenesis NAb natural infection neutralization neutralization activity neutralizing antibody non-immune outbreak pathway Pathways Positive selection Protein provided response responses against responsible SARS coronavirus SARS-CoV SARS-CoV spike protein Somatic Spike protein strain Strategy Support Therapies transfer Transmission viral variant virus virus viruses while zoonotic zoonotic transmission [DOI] 10.1371/journal.ppat.1000197 PMC 바로가기 [Article Type] Research Article