COVID-19 and Brazilian Indigenous PopulationsPerspective Piece Published on 2020-08-092022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, SARS, [키워드] Brazil Care country COVID-19 COVID-19 pandemic dissemination Health lethality rate Population SARS-CoV-2 severe respiratory symptom spread to [DOI] 10.4269/ajtmh.20-0563 PMC 바로가기 [Article Type] Perspective Piece
Testing an early online intervention for the treatment of disturbed sleep during the COVID-19 pandemic (Sleep COVID-19): structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-08-082022-10-29 Journal: Trials [Category] Coronavirus, MERS, [키워드] 1:1 Acute insomnia All participant anticipated Anxiety asleep automatically baseline blinded block size brief intervention caused CBT-I clinical Cluster Complete computer-generated conditions conducted control group COVID-19 COVID-19 pandemic criteria Depression Diagnosis disorder dissemination distress DSM-5 Effectiveness Efficacy element English epilepsy follow-up time Good groups healthy hypothesised impairment IMPROVE include individual Insomnia Insomnia Severity Index Intervention intervention group investigator involved ISRCTN Measures number objective occurred Online intervention outcome outcome measure participant PDF Poor post-intervention Prevent primary outcome measure problem problems protocol provided Qualtrics randomisation randomised randomised controlled trial receive recruited recruitment reduce Registered reported Research Sample size SARS-CoV-2 Schizophrenia secondary seeking severity short-term insomnia Sleep Standard status Study protocol Symptom Testing thought Treatment university website Williams [DOI] 10.1186/s13063-020-04644-0 PMC 바로가기 [Article Type] Letter
Nigella sativa supplementation to treat symptomatic mild COVID-19: A structured summary of a protocol for a randomised, controlled, clinical trialLetter Published on 2020-08-082022-10-29 Journal: Trials [Category] COVID-19, MERS, [키워드] 1:1 absence Admission Alanine transaminase assigned Black seed Blinding block Breast feeding Chronic kidney disease chronic liver disease clinical trial clinically comparator computer-generated randomization conducted control group control groups COVID-19 COVID19 Date defined dialysis disease dissemination Efficacy element eligible patient exploratory glomerular filtration rate hospital Infection intensive care Jeddah King limit medication Mild Nigella Sativa no symptoms number objective Open-label outcome parallel-group participant Patient phytotherapy Pneumonia polymerase chain reaction Prospective protocol radiological randomisation randomised randomised controlled trial Randomly recruited renal respiratory Sample size SARS-CoV-2 Saudi Arabia Standard of care status Symptom symptomatic mild the patient throat swab transfer treat Treatment Trial Two-arm university upper respiratory tract website written Informed Consent [DOI] 10.1186/s13063-020-04647-x PMC 바로가기 [Article Type] Letter
Pakistan Randomized and Observational Trial to Evaluate Coronavirus Treatment (PROTECT) of Hydroxychloroquine, Oseltamivir and Azithromycin to treat newly diagnosed patients with COVID-19 infection who have no comorbidities like diabetes mellitus: A structured summary of a study protocol for a randomized controlled trial당뇨병과 같은 동반 질환이 없는 새로 진단된 COVID-19 감염 환자를 치료하기 위한 Hydroxychloroquine, Oseltamivir 및 Azithromycin의 코로나바이러스 치료(PROTECT) 평가를 위한 파키스탄 무작위 및 관찰 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-08-082022-08-13 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 adaptive age allocation sequence approval authority Azithromycin baseline bioethics blinded Blinding board clinical Clinical improvement clinical status Cohort cohort study Combination combinations Committee Comorbidity comparator computer-generated Controlled trial coronavirus COVID-19 diabete diabetes Diabetes Mellitus diagnosed disease dissemination distress drug dyspneic Effectiveness eight element evaluate excluded expected Final flexibility Follow-up followed by Formal Gender groups Hospitalized Hydroxychloroquine hypertension Infection intervention group kidney Kidney failure lactating liver medical condition monotherapy multi-center multicenter nasal swab nucleic acid number objective observation open open label Ordinal Scale oseltamivir parameter participant patients patients with COVID-19 PCR positive pregnant Primary outcome Primary outcomes protocol public health qRT-PCR random randomization Randomized Randomized controlled trial randomized study recruited recruitment regimen Registered Registration reported respiratory distress Safety Sample size Self-isolation Seven seven-category ordinal scale Standard status Study protocol subject subsequent sulfate test negative tested three groups treat Treatment Trial twice a day Version virus website [DOI] 10.1186/s13063-020-04616-4 PMC 바로가기 [Article Type] Letter
Crosstalk Between Platelets and Microbial PathogensImmunology Published on 2020-08-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adaptive addition Anti-inflammatory Antigen auto bidirectional binding Blood Cell circulating contribute COVID-19 Critical Crosstalk demonstrated Diseases dissemination Effect fetal haemostasis help Host Host immune response host immune responses Immune thrombocytopenia immune-mediated diseases Immunity implication Infection Interaction involved knowledge mechanism microbe microbes microbial microbial pathogens microorganism Neonatal pathogen Pathogenesis Pathogens Platelet Platelets pro-inflammatory recruited response restrict SARS-CoV-2 coronavirus subsequent thrombosis [DOI] 10.3389/fimmu.2020.01962 PMC 바로가기 [Article Type] Immunology
Tai Chi for coronavirus disease 2019 in recovery period A protocol for systematic review and meta analysis3800 Published on 2020-08-072022-10-30 Journal: Medicine [Category] COVID-19, MERS, [키워드] addition Analysis anorexia approval Assessing average Chest Chinese clinical Cochrane Library coronavirus disease Coronavirus disease 2019 cough COVID-19 data extraction database diarrhea dissemination distress Dyspnea effective Effectiveness Ethics evaluate Evidence Fever headache Hospitalization independent information Infrastructure literature Medicine Mortality myalgia nausea Netherland occurrence rate ongoing trial OVID Patient peer-reviewed pharyngalgia Primary outcome protocol registry researcher Result review risk of bia Safe searched secondary outcome serum cytokine levels subject Symptom systematic review Tai Chi temperature Trial VIP vomiting [DOI] 10.1097/MD.0000000000021459 PMC 바로가기 [Article Type] 3800
Integrative illustration for coronavirus outreachCommunity Page Published on 2020-08-062022-10-28 Journal: PLoS Biology [Category] COVID-19, MERS, [키워드] acute respiratory syndrome coronavirus dissemination distribution example knowledge Pathogens PDB Protein Data Bank resource SARS Coronavirus [DOI] 10.1371/journal.pbio.3000815 PMC 바로가기 [Article Type] Community Page
What Media Helps, What Media Hurts: A Mixed Methods Survey Study of Coping with COVID-19 Using the Media Repertoire Framework and the Appraisal Theory of StressOriginal Paper Published on 2020-08-062022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, [키워드] affected age Analysis appraisal approach asked avoidance benefit Canada changes in connection coping coronavirus disease COVID-19 COVID-19 pandemic COVID19 dissemination explained Facebook Factor framework Gender increase in individual infodemic infodemiology information information and communication technologies investigated less lockdowns media men mental health Netflix objective Older pandemic physical physical distancing populations positive predict preferences provided question repertoire respondent responses Result screen time Self-isolation social network Stress Subjective Support survey The United States theory Variation with COVID-19 YouTube [DOI] 10.2196/20186 PMC 바로가기 [Article Type] Original Paper
A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial중환자실에 입원한 COVID-19 환자의 정맥 주사 멜라토닌의 효능과 안전성을 조사하기 위한 2상, 단일 센터, 이중 맹검, 무작위 위약 대조 시험(MelCOVID 연구): 연구 프로토콜의 구조화된 요약 무작위 대조 시험을 위해Letter Published on 2020-08-052022-08-13 Journal: Trials [Category] MERS, 임상, [키워드] 6 hours Acute hypoxemic respiratory failure addition Admission Adult patients adverse effect adverse event adverse events age allocation anticipated Autoimmune disease Biochemical parameters blinded Blinding blood gas blood gas analysis body weight C-reactive protein Caregivers carried chronic Chronic kidney disease clinical condition clinical development commercialization comparator compatible symptom compatible symptoms Complete completion computer conducted Confirmed Consent Control control arm control group COVID-19 COVID-19-associated thromboembolic phenomena Critically ill D-dimer daily dose Date determined by disease dissemination double-blind Efficacy and safety element enzyme EU Clinical Trial evaluate evaluate the effect exclusion criteria expected experimental arm experimental group failing organ failing organs family member ferritin Frequency gas analysis GFR greater hematologic Hemodialysis hypoxemic Hypoxemic respiratory failure ICU ICU admission impairment Inclusion inclusion criteria increase in inflammatory state Informed institutional protocols intensive care intensive care unit interleukin interleukin-6 intravenous Kidney disease legal guardian less liver enzymes maximum mechanical ventilation medical illness melatonin Mortality multi-organ failure normal range number objective Organ failure outcome parameters participant Patient patient condition patients with COVID-19 per day performed phase physician Placebo placebo-controlled randomized trial plasma Plasma levels positive RT-PCR Pregnancy pregnancy test Prevent procalcitonin Program protocol provided randomization randomization sequence Randomized Randomized controlled trial randomized placebo-controlled trial receive recruited recruitment reduced reduction Respiratory failure Sample size SARS-COV-2 infection SAS version 9.4 SAS version 9.4 statistical software secondary Secondary objectives Sequential Organ Failure Assessment severity single center single-center SOFA Spain Stage Standard-of-care statistical status study drug study group study groups study period Study protocol systemic inflammatory response Terminal surgical thromboembolic Treatment Trial Trial registration two-arm parallel Ventilator-free days website with COVID-19 worsening written Informed Consent [DOI] 10.1186/s13063-020-04632-4 PMC 바로가기 [Article Type] Letter
muLTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19-Experimental drugs and mechanisms (TACTIC-E): A structured summary of a study protocol for a randomized controlled trial코비드-19-실험 약물 및 기전(TACTIC-E)으로 입원한 ICu 전 환자에 대한 다중 암 치료 연구: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-07-312022-08-13 Journal: Trials [Category] SARS, 임상, [키워드] able to swallow adaptive Adaptive trial added Admission age Ambrisentan Analysis approved Arm ARMS balloon pump balloon pump) baseline benefit Biomarker blinded Blinding calculated Cambridge Cambridge University Hospitals NHS Foundation Trust can not cardiac cardiovascular complications cells clearance clinical endpoint Clinical endpoints clinical picture clinically Combination comparator comparison Complete Composite Course COVID-19 COVID-19 infection creatinine creatinine clearance CRP Dapagliflozin Data analysis Day death defined demonstrated determine diabetes Diagnosis discretion disease dissemination drug drugs ECMO EDP1815 Efficacy element enrolled envelope EU Clinical Trial EU Clinical Trials EudraCT Evidence evidence of exclusion criteria Experimental drugs failure feature fixed foundation Gault Gender group hypertension immunomodulation immunomodulatory incidence include Inclusion independent independent data monitoring committee Inotropes Intervention Invasive mechanical ventilation investigator Laboratory late stage male mechanism membrane neutrophil Neutrophils NHS number objective Occurrence on admission once daily Open-label open-label trial opinion option Organ failure organ support Other outcome Oxygenation pandemic Parallel Arm participant Patient patients with COVID-19 performed phase platform Platform trial positive positive COVID-19 predicted Primary outcome principal investigator progression protocol Radiographic radiological randomisation randomised Randomized controlled trial recruited reduce Registered related disease renal renal failure risk Sample size severity Standard of care status stratified Study protocol subject Support tablets the patient therapy Treatment treatment arm Trial Trial registration triggered Trust university website [DOI] 10.1186/s13063-020-04618-2 PMC 바로가기 [Article Type] Letter