Innate immunity – Page 62 – Communicable Diseases Research

Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic Suggestions

Review

Published on 2021-02-202022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS,

[키워드] “cytokine storm” activate Activation acute lung injury acute lung injury (ALI) acute respiratory distress acute respiratory distress syndrome (ARDS) Bacterial Bacterial coinfection characteristic characterized Combination coronavirus COVID-19 Cytokine release syndrome Cytokine storm effective eight Evidence exhibiting fungal fungal coinfection Fungal infection fungal infections healthy control hyperinflammation implication Infection Innate Innate immunity Interaction Involving Making mechanism melatonin microbes Mild mild cases mild COVID-19 patient Model NLR NLRP3 novel nucleotide-oligomer-recognition-domain-like receptors (NLR) oligomerization outlined pattern prediction receptor respiratory resulting review SARS-CoV-2 Sepsis severe COVID-19 severe COVID-19 patients suggestion Symptoms syndrome synergistic synergy therapeutic TLR TLR antagonists TLR2 TLR3 TLR4 TLR7 TLR9 Toll-like receptor toll-like receptors (TLR) treating COVID-19
[DOI] 10.3390/ijms22042108 PMC 바로가기 [Article Type] Review

Immunostimulatory siRNA with a uridine bulge leads to potent inhibition of HBV and activation of innate immunity

Research

Published on 2021-02-182023-06-02
Journal: Virology Journal [Category] B형 간염,

[키워드] Hepatitis B virus immunostimulation Innate immunity microRNA-like siRNA msiRNA RNAi
[DOI] 10.1186/s12985-021-01509-z PMC 바로가기 [Article Type] Research

Editorial: Innate Immunity in Normal and Adverse Pregnancy

Article

Published on 2021-02-182023-08-30
Journal: Frontiers in Immunology [Category] E형 간염,

[키워드] complement Infection Innate immunity Innate lymphoid cells Pregnancy
[DOI] 10.3389/fimmu.2021.646596 PMC 바로가기

Novel Coronavirus Disease 2019 (COVID-19) and Cytokine Storms for More Effective Treatments from an Inflammatory Pathophysiology

Review

Published on 2021-02-172022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] Abnormalities ACE2 activate acute respiratory distress Administered Against anti-rheumatic drug bat cause caused Cell cell debris Central nervous system chemokine chemokines China chronic inflammation Coagulation COVID-19 cytokine cytokine receptor Cytokine release syndrome Cytokine storm Damage-associated molecular patterns develop disorders Disseminated intravascular coagulation DNA Effect endothelial cell damage Europe excessive inflammatory response Favipiravir G-CSF global pandemic Host human Angiotensin-converting enzyme IL-1β IL-6 IL-8 immune system Infection Infectious disease Inflammatory response inhibit innate immune system Innate immunity involved IP10 liver melatonin mitochondrial mitochondrial dysfunction Mitochondrial function monoclonal antibodies multiple organ failure new virus novel novel coronavirus diseases (or COVID-19) occur organ damage patients producing Proinflammatory cytokine renal respiratory infection resulting SARS-CoV SARS-CoV-2 second serum storm Stress subject subsequent suppress syndrome TNF-α Tocilizumab treatment for COVID-19 Vascular viral invasion
[DOI] 10.3390/jcm10040801 PMC 바로가기 [Article Type] Review

Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children

소아에서 SARS-CoV-2 감염의 급성 및 회복기 동안의 타고난 세포 프로필

Article

Published on 2021-02-172022-09-10
Journal: Nature Communications [Category] MERS, 유전자 메커니즘, 진단,

[키워드] activated neutrophil Activated neutrophils acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 CD63 cell profile children circulating classical clinically convalescent convalescent phase coronavirus Course COVID-19 dendritic cell dendritic cells disease immune responses immunological immunological mechanism Immunopathogenesis infected children Infection Infectious diseases Innate innate immune response innate immune system Innate immunity low-density Mild mild SARS-CoV-2 infection monocyte Monocytes natural killer cell Natural killer cells neutrophil Neutrophils non-classical monocyte Non-classical monocytes observé PCR testing proportion reduced respiratory SARS-CoV-2 SARS-COV-2 infection subset
[DOI] 10.1038/s41467-021-21414-x PMC 바로가기 [Article Type] Article

COVID-19 and the human innate immune system

Review

Published on 2021-02-162023-06-15
Journal: Cell [Category] MERS, SARS,

[키워드] COVID-19 genetics Granulocytes immunosuppressive cells Innate immunity interferon Monocytes pandemic SARS-CoV-2 trained immunity viral sepsis
[DOI] 10.1016/j.cell.2021.02.029 PMC 바로가기 [Article Type] Review

Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso

면역 시스템의 유전적 변이와 유아의 말라리아 감수성: 부르키나파소 나노로에서의 중첩 사례-대조 연구

Research

Published on 2021-02-162024-08-08
Journal: Malaria Journal [Category] 말라리아,

[키워드] Cytokines Immunogenetic variants Innate immunity malaria Plasmodium falciparum
[DOI] 10.1186/s12936-021-03628-y PMC 바로가기 [Article Type] Research

mRNA vaccine: a potential therapeutic strategy

Review

Published on 2021-02-162022-10-30
Journal: Molecular Cancer [Category] COVID-19, Fulltext, MERS,

Reduced Nucleoprotein Availability Impairs Negative-Sense RNA Virus Replication and Promotes Host Recognition

Article

Published on 2021-02-102023-06-14
Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자,

[키워드] arenavirus Filovirus IFN response Influenza Innate immunity miRNA negative-strand RNA virus paramyxovirus viral replication
[DOI] 10.1128/JVI.02274-20 PMC 바로가기

The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2

Cellular Response to Infection

Published on 2021-02-092022-10-30
Journal: Journal of Virology [Category] COVID-19, SARS,

[키워드] Activation Antiviral antiviral activity cathepsin Cell cellular entry cleavage cleavage site consequence coronavirus COVID-19 entry of SARS-CoV-2 exacerbated expression furin cleavage furin cleavage site furin-like protease glycoprotein IFITM IFITM2 IFITM3 individuals inhibit inhibited innate immune Innate immunity interferons (IFNs late endosomes maturation membrane protein mitigate polybasic potential therapeutic target precursor producer cell promote protease Protein reduce reduce viral replication Replication restrict S1/S2 boundary SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 replication SARS-CoV-2 spike sensitivity Site spike suggested the spike protein therapeutic strategy transmembrane Transmissibility transmissibility of SARS-CoV-2 Transmission Treatment Type type 1 interferon type I type I IFNs type I interferon type II IFN viral entry viral spike viruses
[DOI] 10.1128/JVI.02422-20 PMC 바로가기 [Article Type] Cellular Response to Infection