Drug repurposing: Discovery of troxipide analogs as potent antitumor agents
Research article
[키워드] 4] triazolo[1
5-a] pyrimidines
1
activating
anti-apoptotic
Antiproliferative activity
antitumor agent
Apoptosis
apoptotic signaling
Bax
BCL-2
Bioactivity
cancer cell line
caspase
Cell
Cell migration
cells
cleaved
Compound
death
down-regulated
drug
Drug repurposing
drugs
evaluated
exhibited
expression
extrinsic pathway
feasibility
IC50
indicated
inhibit
inhibited
intrinsic pathway
MCF-7
PARP
pathway
PC3
pro-apoptotic
reported
researcher
significantly increased
suppressed
up-regulated
[DOI] 10.1016/j.ejmech.2020.112471 [Article Type] Research article
[DOI] 10.1016/j.ejmech.2020.112471 [Article Type] Research article