ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trialACCORD: 입원 환자의 COVID-19 치료를 위한 여러 후보 약제의 효능과 안전성을 평가하기 위한 다기관, 원활한, 2상 적응형 무작위화 플랫폼 연구: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-07-312022-08-13 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 a BTK inhibitor Acalabrutinib adaptive added adjusted agent Amendment analyses Analysis Anti-viral approval Arm baseline bemcentinib Blinding block BTK inhibitor candidate Candidates cause caused changed clinical Clinical characteristics Clinical improvement clinically comparator complement COVID COVID-19 current Day discharge disease dissemination dropped Efficacy element Endpoint England estimation EudraCT evaluate Evidence evidence of experimental arm GRADE group help heparin hospital hospitalised include Inflammatory response inhibitor Ireland IRT Mask Master protocol Mild Mild disease monoclonal antibody Multiple nasal prongs National non-invasive ventilation number objective open open label Ordinal Scale outcome oxygen Oxygen therapy oxygen therapy) participant Patient performed Phase 2 phase II platform proceed protocol protocols provide randomisation randomised randomised controlled randomised controlled trial randomization recruited recruitment reduce Registered Regulatory reported Respiratory failure response response rate Safety Sample size SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein seamless selected severity shown SOC Spike protein Stage stage 2 stages Standard of care status stratified Study protocol sustained Task Force technology the spike protein the WHO therapy time treat Treatment treatment of COVID-19 Trial Trial registration Viral viral infection virus website with COVID-19 working zilucoplan [DOI] 10.1186/s13063-020-04584-9 PMC 바로가기 [Article Type] Letter
PROTECT Trial: A cluster-randomized study with hydroxychloroquine versus observational support for prevention or early-phase treatment of Coronavirus disease (COVID-19): A structured summary of a study protocol for a randomized controlled trialStudy Protocol Published on 2020-07-312022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 24 hour addition Administered adverse event all subject allocation sequence Analysis antiviral activity Antiviral effect Arm arrhythmia Asymptomatic bradycardia can be used carried Cell Chronic kidney disease clinical Cluster Clusters Comorbidity Compliance conducted congestive heart failure Contact contraindication Coronaviruses covariates COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 symptom Data monitoring committee database deficiency defined Department diabete diagnostic dialysis disease dissemination diuretics dose drug Drug-drug interactions during treatment early treatment Efficacy element eligible endosomal pH ENhance enrolled Epidemic Epidemiology equation EudraCT evaluate Evidence expected Factor female Final G6PD Generalized generate Glucose-6-phosphate glycosylation group Healthcare professional Hydroxychloroquine hydroxychloroquine/chloroquine identify in vitro in vivo inclusion criteria independent index index case index cases Infection interim analysis involved IRCCS ischemic heart disease Italian region Italy Loading dose male malignancy medication mental illness mild symptoms neurological number objective observation open label oropharyngeal swab outcome parallel group participant Patient patients with COVID-19 Paucisymptomatic performed positive PCR test Prevent prevention prevention of COVID-19 Prophylaxis proportion Proteins protocol protocol amendment Public QT prolongation randomization Randomized Randomized controlled clinical trial Randomized controlled trial reached receive recorded recruited reduced reduction in Registered reported required risk Sample size SARS-CoV-2 shown Standard status stratified Studio Study protocol subject subjects Support Swab Symptom symptomatic syndrome Tablet therapeutic approaches therapy Toxicity treat treated Treatment Trial trial protocol ventricular viral surface virus virus infection website with COVID-19 [DOI] 10.1186/s13063-020-04527-4 PMC 바로가기 [Article Type] Study Protocol
Pre-exposure prophylaxis with hydroxychloroquine for high-risk healthcare workers during the COVID-19 pandemic: A structured summary of a study protocol for a multicentre, double-blind randomized controlled trialLetter Published on 2020-07-292022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 acute respiratory syndrome Adults adverse event antiretroviral Antiviral Arm Barcelona blinded Blood Breastfeeding Chloroquine condition confirmed case confirmed COVID-19 case Contact Control control group Controlled clinical trial coronavirus coronavirus disease Corticosteroid COVID-19 declining defined develop disease dissemination double-blind double-blinded Efficacy element eligibility Epidemic equipment evaluate Follow-up group healthcare worker Healthcare workers high risk hospital Hydroxychloroquine hydroxychloroquine treatment identify incidence Infection Intervention intervention group investigator marker multicentre National number Nurse objective Occurrence Older outcome participant Participants PCR physical Placebo placebo tablet polymerase chain positive PCR PPE pre-exposure predict predictor Pregnancy primary endpoint Prophylaxis protocol random randomisation randomised randomised controlled trial Randomized Randomized controlled trial Rapid diagnostic test RDT reached receive recruited reducing Registered Repository Research risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR Secondary endpoints Seroconversion serological serology serum sample Spain Spanish Standard of care status Study protocol Symptom Tablet the placebo group the SARS-CoV-2 Treatment Trial website with COVID-19 [DOI] 10.1186/s13063-020-04621-7 PMC 바로가기 [Article Type] Letter
RECOVERY- Respiratory Support: Respiratory Strategies for patients with suspected or proven COVID-19 respiratory failure; Continuous Positive Airway Pressure, High-flow Nasal Oxygen, and standard care: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-07-292022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] age allocation concealment anticipated ARMS Blinding Care clinical clinically comparator Complete computer-generated conducted Continuous Continuous Positive Airway Pressure COVID-19 CPAP Critical care current death decision determine dissemination effective Effectiveness element eligible England Escalation exclusion criteria Face mask fraction Gender group-sequential HFNO High-flow nasal oxygen hospital Hospital stay include inclusion criteria Inpatient Intervention intubate intubation intubation rate invasive ventilation Ireland ISRCTN maintain mechanical ventilation Mortality mortality rate nasal nasal oxygen number objective Open-label outcome outcomes oxygen oxygen inhalation therapy Palliation parallel group participant Patient performed peripheral oxygen saturation plan positive airway pressure Pragmatic pressure Primary outcome protocol Public randomisation randomised randomised controlled randomised controlled trial Randomized receive recovery reported required researcher respiratory Respiratory failure risk Sample size secondary secondary outcome sequence Standard standard care standard oxygen therapy status Strategy stratified Study protocol System therapy tracheal Treatment Trial Version website Withdrawal [DOI] 10.1186/s13063-020-04617-3 PMC 바로가기 [Article Type] Letter
The B-MaP-C study: Breast cancer management pathways during the COVID-19 pandemic. Study protocolResearch Paper Published on 2020-07-292022-10-31 Journal: International Journal of Surgery Protocols [Category] COVID-19, [키워드] affecting Analysis approval assist Audit Breast Breast cancer breast cancer patient Cancer Care change coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 pandemic Data analysis diagnosed dissemination eligible Ethics for inclusion global pandemic healthcare implication International Local management National outcomes pandemic pathway Patient protocol Registration required SARS-CoV-2 standard treatment submitted Treatment United Kingdom women [DOI] 10.1016/j.isjp.2020.07.003 PMC 바로가기 [Article Type] Research Paper
Social media influence in the COVID-19 PandemicReview Article Published on 2020-07-272022-10-29 Journal: International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology [Category] Coronavirus, SARS, [키워드] approach COVID-19 COVID-19 diagnostic testing [Supplementary Concept] COVID-19 pandemic diagnostic disadvantage disseminate dissemination help information Information dissemination pandemic protocols responsible social media social media platform Treatment [DOI] 10.1590/S1677-5538.IBJU.2020.S121 PMC 바로가기 [Article Type] Review Article
Belief in a COVID-19 Conspiracy Theory as a Predictor of Mental Health and Well-Being of Health Care Workers in Ecuador: Cross-Sectional Survey StudyOriginal Paper Published on 2020-07-212022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, SARS, [키워드] 2019-nCoV active site analyzed Anxiety association belief conducted conspiracy coronavirus coronavirus disease COVID-19 COVID-19 pandemic disorder dissemination distress Ecuador Evidence groups Health care worker health care workers help identify investigated lab Latin America Linear regression Logistic regression mental health mental health service objective pandemic prediction psychiatric identification Psychological distress Result Satisfaction social media social media platform survey theory virus Well-being worker [DOI] 10.2196/20737 PMC 바로가기 [Article Type] Original Paper
Impact of self-imposed prevention measures and short-term government-imposed social distancing on mitigating and delaying a COVID-19 epidemic: A modelling study자체 예방 조치와 정부의 단기 사회적 거리두기가 COVID-19 전염병 완화 및 지연에 미치는 영향: 모델링 연구Research Article Published on 2020-07-212022-08-13 Journal: PLoS Medicine [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alexandra Analysis assumed attack rate Awareness best cause caused China Clinical studies Contact coronavirus coronavirus disease country COVID-19 COVID-19 epidemic demographics diagnose diagnosed diagnoses disease disease status dissemination effective Effectiveness Effects Efficacy Epidemic Epidemics epidemiological estimate evaluate Government handwashing Health policy Healthcare system Healthcare systems Height heterogeneity Impact implementation individual information initiated Intervention Isolation lifted Mask measure Mild mitigate mixing not affect Novel coronavirus outcome parameter Prevent prevented provide public health recommendation reduce reduced Reinfection researcher respiratory SARS-CoV-2 seeking severe acute respiratory syndrome Coronavirus severe disease significantly social distancing Spread spread of COVID-19 spread to stratified Stress susceptible the epidemic the timing Transmission model with COVID-19 [DOI] 10.1371/journal.pmed.1003166 PMC 바로가기 [Article Type] Research Article
Efficacy of local budesonide therapy in the management of persistent hyposmia in COVID-19 patients without signs of severity: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-07-202022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 addition alveolar association blinded breastfeeding women Budesonide cause chest CT scan close contact Control control groups Corticosteroid COVID-19 COVID-19 patient criteria CYP3A4 inhibitor disorder dissemination dysgeusia Efficacy element form France HIV hypersensitivity Hyposmia Inclusion intranasal Local Loss of Smell management MRI nasal Nasal Irrigation nodule number objective olfactory onset of symptom onset of symptoms Open-label ophthalmic Other outcome parallel group Paris participant Patient patients PCR PCR-confirmed percentage physiological saline positive serology protease protocol randomised randomised controlled trial randomization list Randomized recruited Registered rehabilitation Rothschild rotocol Sample size SARS-CoV-2 SARS-COV-2 infection severity status stratified Study protocol therapy Treatment Trial two group Version virus website [DOI] 10.1186/s13063-020-04585-8 PMC 바로가기 [Article Type] Letter
Mathematical model describing CoViD-19 in São Paulo, Brazil – evaluating isolation as control mechanism and forecasting epidemiological scenarios of releaseOriginal Paper Published on 2020-07-202022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, [키워드] activities basic reproduction number Brazil Care collected coronavirus disease death deterministic model dissemination Epidemic epidemiological Epidemiological scenarios evaluated Health hospitalisation Isolation less mathematical mathematical model mechanism New coronavirus Numerical simulations occurred parameters proportion proportions pulses of release rapid increase reducing Registered Release released subpopulations the epidemic unique pulse of isolation/quarantine [DOI] 10.1017/S0950268820001600 PMC 바로가기 [Article Type] Original Paper