Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trialRandomized Controlled Trial Published on 2021-08-012022-10-05 Journal: The Lancet. Respiratory Medicine [Category] SARS, 유전자 메커니즘, 임상, [키워드] 1:1 ACEi ACEIs Admission angiotensin-converting enzyme 2 ARBs assigned AUC blocker cardiovascular center Course COVID-19 dead death died eight Endpoint enrolled faster females Germany had no human cell Hypothesis inhibitor intensive care mechanical ventilation median median age mitigate modified intention-to-treat no significant difference Older Open-label organ dysfunction Organ failure outcome parallel group Patient patients died randomised Randomly RAS receptor Registered renin-angiotensin system risk SARS-CoV-2 entry Science scored secondary severity of COVID-19 significant effect significantly lower SOFA SOFA score symptomatic SARS-CoV-2 infection the primary endpoint therapy treated Treatment Trial upregulated [DOI] 10.1016/S2213-2600(21)00214-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
Treatment and outcomes of pediatric patients with cancer and COVID-19 at MAHAK pediatric cancer treatment and research center, Tehran, IranResearch article Published on 2021-08-012022-10-05 Journal: Seminars in oncology [Category] SARS, 진단, 치료법, [키워드] Affect antibodies Asymptomatic Brain Cancer cancer treatment center conducted coronavirus COVID-19 COVID-19 pandemic COVID-19 symptom diagnosing Diagnosis Diagnostic Criteria eight enrolled FIVE Hospitalized IgG and IgM Immunosuppressed Inpatient Iran leukemias Mild molecular nine oncology patient outcome Outpatient Patient patients patients died pediatric Pediatric patient pediatrics positive Research SARS-COV-2 infection SARS-CoV-2 infections Seven study period Tehran tested Treatment tumors with COVID-19 [DOI] 10.1053/j.seminoncol.2021.09.003 [Article Type] Research article
Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortalityproapoptotic sFas 및 antiapoptotic Bcl2 및 COVID-19 환자 사망률의 혈중 농도Observational Study Published on 2021-08-012022-09-11 Journal: Expert review of molecular diagnostics [Category] MERS, 바이오마커, 임상, [키워드] 95% CI antiapoptotic APACHE association BCl2 best blood concentration Blood level blood levels Canary Island Canary Islands circulating Concentration COVID-19 patient COVID-19 patients COVID-19: patients determine eight extrinsic pathway ICU ICU admission intensive care unit intrinsic pathway knowledge Logistic regression Mortality Patient Prospective Study Protein serum serum concentrations serum levels sFas. SOFA Spain was performed [DOI] 10.1080/14737159.2021.1941880 PMC 바로가기 [Article Type] Observational Study
Videoconferencing to deliver genetics services: a systematic review of telegenetics in light of the COVID-19 pandemic유전학 서비스를 제공하기 위한 화상회의: COVID-19 전염병에 비추어 원격 유전학의 체계적인 검토Article Published on 2021-08-012022-09-11 Journal: Genetics in medicine : official journal of the Ame [Category] SARS, 유전자 메커니즘, 임상, [키워드] alternative method Anxiety applicability concerning conducted counseling COVID-19 pandemic database debatable Depression eight evaluate evaluated Evidence face-to-face contact Genetic genetics health-care identify inclusion criteria knowledge moderate outcome outcomes Patient Patient satisfaction reduction in reorganization risk of bia sample sizes Satisfaction specialist synchronous systematic review videoconferencing [DOI] 10.1038/s41436-021-01149-2 PMC 바로가기 [Article Type] Article
Examining reporting and representation of patients with cancer in COVID-19 clinical trialsCOVID-19 임상 시험에서 암 환자의 보고 및 대표성 검토Article Published on 2021-08-012022-09-11 Journal: Cancer Reports [Category] SARS, 임상, [키워드] Cancer cancer diagnosis Clinical research clinical research participants clinical trial clinical trials collected COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 treatments Critical Disparities Efficacy eight Europe evaluated Evidence Examining greater initial search knowledge North America participated Patient patients Patients with cancer Prevalence proportion recruited reported Reporting representation Research researcher retrospective Study design study population the United State therapeutic Therapeutics therapy trial participant trial participants Tumor United States [DOI] 10.1002/cnr2.1355 PMC 바로가기 [Article Type] Article
Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis, first updateCOVID-19 환자에서 토실리주맙의 효능 및 안전성: 살아있는 체계적인 검토 및 메타 분석, 첫 번째 업데이트Meta-Analysis Published on 2021-08-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단, [키워드] 30-Day mortality 95%CI adjusted approach certainty of evidence citation Cohort concerning Controlled Corticosteroids COVID COVID-19 COVID-19 patients Daily death Efficacy eight elevated eligible evaluate evaluated Evidence examined Google higher risk hospitalized COVID-19 patients hospitalized patient IL-6 IL-6 receptor Infection interleukin-6 Intervention lower risk majority mechanical ventilation Meta-analysis moderate Mortality Multiorgan observational study Other outcome OVID participant Patient patients Placebo random effect Randomized controlled trial RCT RCTs RECOVERY trials reduce REMAP-CAP risk Risk of bias risk ratio RRs Secondary infection Serious Adverse Event Seven severe coronavirus disease severe COVID-19 Standard of care syndrome systematic review Tocilizumab Toxicity treat Treatment Web of Science [DOI] 10.1016/j.cmi.2021.04.019 PMC 바로가기 [Article Type] Meta-Analysis
Impact of COVID-19 on Thrombus Burden and Outcome in Acute Myocardial InfarctionCardiology Published on 2021-08-012022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Acute myocardial infarction all-cause mortality burden cardiovascular Co-infection co-morbidities co-morbidity Complication composite endpoint coronary thrombus coronavirus disease COVID COVID-19 COVID-19 infection death diagnosed discharge eight Hospital admission Impact increased mortality Infection Laboratory manifestation Mortality Myocardial infarction outcome Pain Patient patients Percutaneous coronary intervention Primary outcome Result retrospective st-elevation myocardial infarction (stemi) study population Symptom the patient thrombus burden with COVID-19 [DOI] 10.7759/cureus.16817 PMC 바로가기 [Article Type] Cardiology
Methylation of Host Genes Associated with Coronavirus Infection from Birth to 26 YearsArticle Published on 2021-07-312022-10-31 Journal: Genes [Category] COVID-19, [키워드] age alteration Analysis analyzed association autosome biological processes Birth children Cluster Cohort conducted coronavirus Coronavirus infection Coronaviruses COVID-19 CpG disease severity DNA methylation Effect eight enrichment analysis Epigenetic epigenetics evaluated explain explained expression FDR female FIVE Gene Expression groups Host identify Infection IoW cohort male mapped Mortality non-specific outcome repeated representing SARS-CoV2 Seven Sex chromosome sex chromosomes statistically significant stratified by sex susceptibility Symptoms the SARS-CoV-2 transcriptional unique Variability was performed were assessed were used Wight Year [DOI] 10.3390/genes12081198 PMC 바로가기 [Article Type] Article
Charting elimination in the pandemic: a SARS-CoV-2 serosurvey of blood donors in New Zealand대유행의 차트 제거: 뉴질랜드의 헌혈자에 대한 SARS-CoV-2 혈청 조사Short Paper Published on 2021-07-302022-09-12 Journal: Epidemiology and Infection [Category] SARS, 진단, [키워드] 95% confidence interval adjusted Algorithm blood donor Blood donors collected community transmission COVID-19 COVID-19 cases disease Donor eight eliminating Elimination Health high risk immunoassay incidence Infection New New Zealand Prevalence provide Receptor binding domain Region regions reported robust Sample SARS-CoV-2 SARS-CoV-2 antibodies Sensitivity and specificity serological evidence Serological testing seropositive seropositive sample Seroprevalence Serosurvey Seven specificity spike Spread Support utilised [DOI] 10.1017/S0950268821001643 PMC 바로가기 [Article Type] Short Paper
COVID-19 Reinfection in a Young Medical Doctor: A Case Report젊은 의사의 COVID-19 재감염: 증례 보고Case Reports Published on 2021-07-302022-09-11 Journal: JNMA: Journal of the Nepal Medical Association [Category] SARS, 변종, [키워드] Chest Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm Depression diarrhea differential diagnose differential diagnoses dimer discharge eight ferritin Fever fibrosis high fever Infection linear lymph nodes Measures Mild myalgia Nepal pleural effusion professional Reactivation Reinfection report Symptom syndrome tomography Treatment vaccination variant with COVID-19 [DOI] 10.31729/jnma.6450 PMC 바로가기 [Article Type] Case Reports