Duration of post–COVID-19 symptoms is associated with sustained SARS-CoV-2–specific immune responses코로나19 이후 증상의 지속 기간은 지속적인 SARS-CoV-2 특정 면역 반응과 관련이 있습니다.Research Article Published on 2021-08-092022-09-12 Journal: JCI Insight [Category] MERS, SARS, 진단, [키워드] Adaptive immunity antibody Antigen CD4 cell population circulating correlation COVID-19 COVID-19 patient COVID-19 symptom COVID-19 symptoms demonstrated Duration etiology evaluated expected follicular groups helper cell IgG immune cell types immune response immune responses immune signature immunology individual investigated magnitude marker median PASC Patient Peripheral blood persistence phenotypic resolved SARS-COV-2 infection SARS-CoV-2 spike protein Significant Spike protein subset sustained Symptom symptom duration symptom resolution systemic inflammation T cell T cell response T cells Viral antigen viral antigens [DOI] 10.1172/jci.insight.151544 PMC 바로가기 [Article Type] Research Article
Immunity to SARS‐CoV‐2 induced by infection or vaccination감염 또는 예방접종으로 유발된 SARS-CoV-2에 대한 면역Review Published on 2021-08-052022-09-10 Journal: Journal of internal medicine [Category] MERS, SARS, 변종, 진단, [키워드] antibody Antibody responses Arm arms race B cell B cells clearance Community concerning COVID‐19 COVID‐19 Critical effective exceptional highlight immune response immune responses in viral Infection Mutation Neutralizing antibodies neutralizing antibody pandemic performed population immunity protective immunity researcher response responses against SARS‐CoV‐2 SARS‐CoV‐2 Seroprevalence significant difference vaccination Vaccine Vaccines variant Viral viral clearance viral variant Viral variants virus viruses [DOI] 10.1111/joim.13372 PMC 바로가기 [Article Type] Review
Gamma-irradiated SARS-CoV-2 vaccine candidate, OZG-38.61.3, confers protection from SARS-CoV-2 challenge in human ACEII-transgenic mice감마-조사 된 SARS-COV-2 백신 후보자, OZG-38.61.3은 인간 aceii-transgenic 마우스에서 SARS-COV-2 도전으로부터 보호를 제공한다.Article Published on 2021-08-042022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 비임상, 유전자 메커니즘, 진단, 치료제, [키워드] added applied approach BALB/c mice breath caused cellular immune responses Challenge test clinical trial copy numbers COVID-19 pandemic dose Efficacy followed by Hepatitis hepatitis A histological analysis Human humoral Humoral and cellular immune responses immune responses immunization immunized immunogenicity inactivated Inactivated Vaccines inactive Infectious diseases lung lung tissues mice Neutralizing antibodies neutralizing antibody Oropharyngeal pandemic Pathogenesis Phase 1 Phase 1 clinical trial Protective purification SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 viral RNA SARS-CoV-2 virus shown smallpox the SARS-CoV-2 virus the vaccine Toxicity transgenic mice Vaccine vaccine candidate Vaccine development Viral Viral RNA virus [DOI] 10.1038/s41598-021-95086-4 PMC 바로가기 [Article Type] Article
Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replicationSARS-COV-2 복제에서 NSP7, NSP8 및 NSP12의 과도 및 안정화 된 복합체Articles Published on 2021-08-032022-09-10 Journal: Biophysical Journal [Category] MERS, SARS, 유전자 메커니즘, [키워드] activities addition amplify atomic Combination complex complexation complexes component components conducted conformation Coordinate crystal structure crystal structures Crystallography defined Disruption DNA form functions greater high-resolution crystal structure Host host immune responses immune responses Interaction make up mechanism mRNA new virus Nsp12 Nsp7 NSP8 Propagation Protein Proteins recognizing Replication reported responsible RNA RNA-dependent RNA polymerase RTC SANS SARS-CoV-2 SARS-CoV-2 replication SAXS scattering size exclusion chromatography Structure Transcription Transient viability Viral Viral proteins Viral RNA virus [DOI] 10.1016/j.bpj.2021.06.006 PMC 바로가기 [Article Type] Articles
Long Noncoding RNAs as Emerging Regulators of COVID-19COVID-19의 새로운 조절자로서의 긴 비코딩 RNAReview Published on 2021-08-022022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] (Tocilizumab) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral immune response antiviral immune responses antiviral role biological processe biological processes cellular changes in Clinical treatment coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 treatment death Dexamethasone disease drug Evidence expression glucocorticoid Glucocorticoids help Host host transcriptome immune dysfunction Immune escape immune responses incidence rate indicate Infection Inflammatory response inhibiting interferons involved lncRNA lncRNAs Long long noncoding RNA mechanisms monoclonal antibodies monoclonal antibody Occurrence pandemic pathology regulate Regulation regulator Research respiratory resulting RNA SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spread subsequent therapeutic thrombosis Tocilizumab Transcriptome Treatment type I interferon type I interferons up-regulate Viral viral gene viral genes viral infections viral replication virus infection virus infections [DOI] 10.3389/fimmu.2021.700184 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Vaccination in IBD: Past Lessons, Current Evidence, and Future ChallengesIBD의 SARS-CoV-2 예방 접종: 과거 교훈, 현재 증거 및 미래 과제Review Published on 2021-08-022022-09-11 Journal: Journal of Crohn's & colitis [Category] SARS, 변종, [키워드] cellular challenge Community complications of COVID-19 COVID-19 current Effectiveness Evidence Future high risk humoral IBD identify immune response immune responses immunogenicity immunosuppressive immunosuppressive therapy in some individual Infection Inflammatory bowel disease inflammatory bowel diseases knowledge lAbel off-label pandemic Patient patients SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines therapy translated trials vaccination Vaccination strategies Vaccination strategy Vaccine Vaccines variants were excluded [DOI] 10.1093/ecco-jcc/jjab046 PMC 바로가기 [Article Type] Review
Immunological mechanisms of vaccine-induced protection against COVID-19 in humans인간에서 COVID-19에 대한 백신 유도 보호의 면역학적 메커니즘Review Published on 2021-08-012022-09-11 Journal: Nature reviews. Immunology [Category] MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] Adenovirus adenovirus vaccine antibody approval approved Cell COVID-19 COVID-19 vaccine detectable dose driving Effector mechanism Efficacy elicit functions Human identifying immune immune responses inactivated innate immune mechanism mechanisms moderate MOST mRNA mRNA vaccine NAb NAbs Neutralizing antibodies neutralizing antibody phase III trial Phase III trials Protein subunit reported response SARS-CoV-2 spike protein single dose Spike protein T cell T cell responses T cells T helper the SARS-CoV-2 These data Vaccine development Vaccines virus Virus neutralization [DOI] 10.1038/s41577-021-00578-z PMC 바로가기 [Article Type] Review
Proteomic and metabolomic investigation of serum lactate dehydrogenase elevation in COVID-19 patientsCOVID-19 환자의 혈청 젖산 탈수소효소 상승에 대한 단백질체 및 대사체 연구Article Published on 2021-08-012022-09-11 Journal: Proteomics [Category] 유전자 메커니즘, [키워드] Activation Admission biochemical Biomarker Blood coagulation cascade clinical and laboratory parameters complement Complement cascade consequence COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity declined degranulation differential expression differentially expressed disease course elevated enrolled exhibited expression expressions group hypoxia immune response immune responses Inflammation Inflammatory responses laboratory parameter Lactate lactate dehydrogenase LDH lipid metabolism metabolism metabolomic metabolomics molecular mechanism molecular mechanisms MONITOR Patient patient severity Platelet Prognosis prognostic indicator protein ubiquitination proteomic proteomics pyruvate Quantitative response serum serum lactate severity shown subset threshold tissue injury was determined with COVID-19 [DOI] 10.1002/pmic.202100002 PMC 바로가기 [Article Type] Article
The COVID-19 vaccine development: A pandemic paradigmCOVID-19 백신 개발: 팬데믹 패러다임Review Published on 2021-08-012022-09-11 Journal: Virus research [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Antibody-dependent enhancement approved boost clinical trial clinical trials Combination coronavirus country COVID-19 COVID-19 vaccine COVID-19 vaccine development death develop disease distribution Effect effort Emergency Emergency use epidemiological Evidence evidence of feasible followed by human population human populations immune immune response immune responses immunization immunize include initiate logistics molecular Neutralizing antibodies nine nucleic acid outcome overcome pandemic paradigm phase 3 results platform predict Protein reduce Regulatory Authorities regulatory authority respiratory SARS-CoV-2 Severe acute respiratory syndrome Trial Vaccine Vaccine design Vaccine development vaccine safety Vaccine strategies. Vaccine-resistant variants variants of SARS-CoV-2 Viral [DOI] 10.1016/j.virusres.2021.198454 PMC 바로가기 [Article Type] Review
Antibody Responses After mRNA-Based COVID-19 Vaccination in Residential Older Adults: Implications for Reopening거주 노인에서 mRNA 기반 COVID-19 백신 접종 후 항체 반응: 재개방에 대한 시사점Article Published on 2021-08-012022-09-11 Journal: Journal of the American Medical Directors Associat [Category] SARS, 치료기술, [키워드] adaptive Adults advanced age All participant All participants Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody antibody level antibody levels Antibody Response assisted living B.1.1.7 Beckman Coulter blinded calculated Care coefficients collected Community condition conducted correlated correlation COVID-19 COVID-19 vaccines criteria cross-sectional Descriptive statistics detectable evaluated Factor greater IgG immune response immune responses Immunity Immunoglobulin Impact impair independent independent living Long-term care magnitude males mounted mRNA mRNA-based mRNA-based COVID-19 vaccine Multiple linear regression multiple linear regression analysis neutralization titer neutralization titers nursing homes Older older adult participant Pearson correlation personal care personal care living Pittsburgh protective effect Protective effects provide pseudovirus pseudovirus neutralization titers. Quality improvement reflex reopening response risk SARS-CoV-2 SARS-CoV-2 pseudovirus sera setting Spearman Steroids use of steroids vaccination Variation [DOI] 10.1016/j.jamda.2021.06.006 PMC 바로가기 [Article Type] Article