Highly accurate whole-genome imputation of SARS-CoV-2 from partial or low-quality sequencesTechnical Note Published on 2021-12-022022-10-31 Journal: GigaScience [Category] COVID-19, SARS, [키워드] Amplicon cause complex condition Genome genomes IMPROVE imputation in viral Lineage lineages Linkage disequilibrium pathogen Phylogeny Precision predict producing reference panel Result SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 pandemic SARS-CoV-2 sequencing sequence sequenced sequencing data Surveillance utility virus was tested whole-genome imputation whole-genome sequencing [DOI] 10.1093/gigascience/giab078 PMC 바로가기 [Article Type] Technical Note
Predictors of COVID-19 Vaccine Acceptance and Hesitancy among Healthcare Workers in Southern California: Not Just “Anti” vs. “Pro” VaccineArticle Published on 2021-12-022022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acceptance cause collected contributing to COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine evaluated Factor group Health healthcare professionals healthcare worker Hesitancy highlight hospital Intervention Nurses offered participant Participants Physicians professionals receive response SARS-CoV-2 shown the vaccine vaccination Vaccine Vaccine acceptance Vaccine hesitancy white women worker [DOI] 10.3390/vaccines9121428 PMC 바로가기 [Article Type] Article
Can Africa achieve herd immunity?Perspective Published on 2021-12-022022-10-31 Journal: Global Health Research and Policy [Category] COVID-19, SARS, [키워드] Africa African average basic reproduction number Can cause Community country COVID-19 COVID-19 vaccine described develop distribution effective excluded Factor globe healthcare services herd immunity immune Immunity Infection Infectious disease less over population immunity recorded secondary case vaccination Vaccine Vaccines World Health Organization [DOI] 10.1186/s41256-021-00231-1 PMC 바로가기 [Article Type] Perspective
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopeniaChAdOx1 nCoV-19 백신 유도 면역 혈전성 혈소판 감소증에 대한 통찰력Article Published on 2021-12-022022-09-11 Journal: Blood [Category] SARS, 유전자 메커니즘, 진단, [키워드] abundance activated addition Adverse reaction aggregate Analysis antibody antibody production antigenic AstraZeneca Autoimmune B-cell response Biomarkers cause ChAdOx1 ChAdOx1 nCoV-19 complex complexes component determinant determinants dissemination DNA EDTA elevated ethylenediaminetetraacetic acid HEK293 heparin heparin-induced thrombocytopenia immune immune responses immunohistochemistry insight mechanism mice Microscopy Mouse models NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils Pathogenesis pathologic Patient patients PF4 Platelet platelet factor 4 platelet surface Platelets polyphosphate procoagulant proinflammatory Protein proteomics reaction resulting SARS-CoV-2 serum stimulate stimulated Support thrombocytopenia thromboembolic thrombosis thrombotic Thrombotic thrombocytopenia Trigger Vaccine vascular leakage virus [DOI] 10.1182/blood.2021013231 PMC 바로가기 [Article Type] Article
Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific glial proteinsSARS-COV-2 스파이크 에피토프 서열의 분자 도킹으로 인간 Zo-1, TLR8 및 뇌 특이적 신경교 단백질과의 이종이량체 펩티드-단백질 복합체 형성 확인Article Published on 2021-12-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 유전자 메커니즘, [키워드] allele asphyxia binding Blood brain barrier blurred vision Brain Brain infection cause clinical observation clinical observations complex death deviation docking epitope epitope peptide Epitopes experiment Glia glial cell headache heterodimeric HLA-DRB1 Human brain human population Hypothesis identify immunogenic induce infect Infection Inflammation Interaction Loss of Smell mechanism modify molecular molecule NDRG2 neurological abnormalities neurological abnormality observation observations peptide peptides performed Protein Proteins question receptor respiratory tract illness RMSD root S100B SARS-CoV-2 SARS-COV-2 infection selected sequence specific protein spike spike epitopes Spike protein structures Symptoms tested the Spike TLR TLR8 Toll-like receptor VCAM1 virus working hypothesis zonula zonula occludens [DOI] 10.1016/j.mehy.2021.110706 PMC 바로가기 [Article Type] Article
Kidney allograft biopsy findings after COVID-19코로나19 이후 신장 동종이식 조직 검사 결과Article Published on 2021-12-012022-09-11 Journal: American journal of transplantation : official jou [Category] SARS, 치료기술, [키워드] Acute kidney injury Allograft allograft dysfunction arteritis biopsies biopsy black Case series cause Clinical research clinical research / practice Collapsing Complication complication: infectious COVID-19 COVID-19 pneumonia direct viral infection dysfunction electron microscopy evaluated female FIVE Follow-up glomerulopathy histologic finding immunohistochemistry Immunosuppression In situ hybridization Infarction Infection infection and infectious agents - viral infectious infectious agent infectious agents Injury kidney kidney (allograft) function / dysfunction kidney transplant recipient kidney transplantation / nephrology mechanical ventilation median age Microscopy Most patients nonspecific Pathologies Patient patients died performed Pneumonia positive SARS-CoV-2 PCR reduced rejection reported required Research SARS-CoV-2 two patients viral infection were infected [DOI] 10.1111/ajt.16804 PMC 바로가기 [Article Type] Article
Secretome of Mesenchymal Bone Marrow Stem Cells: Is It Immunosuppressive or Proinflammatory?Article Published on 2021-12-012022-11-16 Journal: Bulletin of experimental biology and medicine [Category] SARS, 치료기술, [키워드] Allogeneic Anti-inflammatory approved Autoimmune disease bone Bone marrow cause Cell cell transplantation characterized chemokine Clinical use condition conditions COVID-19 patient Culture cytokine profile Cytokine storm Cytokines disease functions Graft-versus-host disease GVHD hematopoietic stem cell transplantation IL-10 IL-4 IL-6 IL-8 IMPROVE Intensive Marrow MCP-1 mesenchymal stem cell Mesenchymal stem cells MSC Pathogenesis proinflammatory protocols reaction reduce required risk STEM stem cells therapeutic therapy tolerogenic Treatment [DOI] 10.1007/s10517-021-05371-5 PMC 바로가기
Severe acute respiratory syndrome coronavirus 2 causes lung inflammation and injuryReview Published on 2021-12-012022-10-04 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome affected alveolar epithelial cells antiviral therapy asymptomatic infections cause caused Clinical practice consequence content coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm death develop effective future therapeutic Health health-care system immune response individual Inflammatory Inflammatory responses Injury lack lung damage Lung inflammation lung inflammatory response Lung injury mechanism mechanisms Middle East Mild molecular mechanism objective pathogenic pathway public health pyroptosis reference Research respiratory syndrome coronavirus SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severe disease Source thrombotic tissue repair Transmissibility Treatment [DOI] 10.1016/j.cmi.2021.11.022 PMC 바로가기 [Article Type] Review
Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccinesSARS-CoV-2에서 떠오르는 주목할만한 스파이크 단백질 돌연변이의 역학 예측은 업데이트된 백신의 필요성을 의미합니다Article Published on 2021-12-012022-09-11 Journal: Biochimie [Category] SARS, 변종, 진단, [키워드] addition Alpha antigenicity B.1.1.7 B.1.351 B.1.617.2 Beta binding cause clade cleavage conformational change COVID-19 D614G Delta dominant variant Dynamics Efficacy exhibited flexibility furin furin cleavage Gamma human cell include lack molecular molecular dynamics Mutation mutation D614G neutralization Nextstrain notable other variant other variants P.1 pathogenicity polybasic predict previous study Protein question RBD Receptor-binding domain SARS-CoV-2 spike Spike protein stability structural biology Structure Superimposition the antibody the receptor-binding domain the spike protein Thermodynamics Vaccine Vaccines variant variants virus wild type Wuhan [DOI] 10.1016/j.biochi.2021.08.011 PMC 바로가기 [Article Type] Article
Drug repurposing in COVID-19: A review with past, present and futureResearch article Published on 2021-12-012022-10-05 Journal: Metabolism Open [Category] 신약개발, 임상, 치료제, [키워드] ACE2 Applying approach approaches approved cause clinical conditions clinical trials conducted coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 disease COVID19 drug Drug repurposing effective Effectiveness ENCODE Favipiravir FDA food Genome global public health host cell surface identify in vitro infection process initiate Interaction molecular docking problems protease inhibitors Protein Protein structure‐based drug design Remdesivir reuse ribavirin Ritonavir RNA virus SARS CoV2 SARS-CoV2 shown single-stranded positive-sense spike structural proteins therapeutic agent Tocilizumab treat [DOI] 10.1016/j.metop.2021.100121 [Article Type] Research article