Breakpoint modelling of temporal associations between non-pharmaceutical interventions and symptomatic COVID-19 incidence in the Republic of IrelandResearch Article Published on 2021-07-292022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] age association breakpoint conditions Confirmed country COVID-19 COVID-19 case COVID-19 incidence COVID-19 transmission deciles decrease Deprivation Divergence Effect effective eight Future Health identify increase increasingly infections initiated Intervention Ireland lockdown lockdowns mitigate National NPI NPIs Patient phase Population profile profiles regions reported required responses Result socio-demographic subgroup symptomatic [DOI] 10.1371/journal.pone.0255254 PMC 바로가기 [Article Type] Research Article
Loop-Mediated Isothermal Amplification (LAMP): The Better Sibling of PCR?루프 매개 등온 증폭(LAMP): PCR의 더 나은 형제?Review Published on 2021-07-292022-09-11 Journal: Cells [Category] SARS, 진단, 치료기술, 치료제, [키워드] amplified Analysis Better Chemical conducted denaturation diagnostic DNA DNA polymerase Effectiveness eight faster highlight incubator isothermal amplification Japanese LAMP LAMP method less Loop-mediated isothermal amplification naked eye PCR primer Primers RNA RT-LAMP SARS-CoV-2 SARS-CoV-2 detection sibling targets temperature [DOI] 10.3390/cells10081931 PMC 바로가기 [Article Type] Review
Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display librariesArticle Published on 2021-07-272022-10-04 Journal: Cell Discovery [Category] 변종, [키워드] 2B11 ACE2-binding site acute respiratory syndrome antibodies antibody B.1.1.7 B.1.1.7 variant B.1.351 Combination complexes convalescent coronavirus COVID-19 convalescent patients effective intervention Efficacy Efficiency eight epitope Epitopes exhibited experiment Genes heavy chain highest affinity IGHV immune Immunoglobulin immunology in vivo mice NAb neutralization neutralization potency Neutralizing neutralizing antibody overlap P.1 PBMC Prophylactic pseudoviruses public health RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 virus SARS-CoV-2-neutralizing antibody Screening structural biology the receptor-binding domain the S1 protein therapeutic Treatment variant viruses wild-type WT SARS-CoV-2 [DOI] 10.1038/s41421-021-00295-w PMC 바로가기 [Article Type] Article
Comparative effectiveness and safety of 32 pharmacological interventions recommended by guidelines for coronavirus disease 2019: a systematic review and network meta-analysis combining 66 trials2019년 코로나바이러스 질병 가이드라인에서 권장하는 32가지 약리학적 중재의 비교 효과 및 안전성: 66건의 시험을 결합한 체계적인 검토 및 네트워크 메타 분석Meta-Analysis Published on 2021-07-272022-09-11 Journal: Chinese medical journal [Category] meta-analysis, SARS, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus adverse event Antibiotics antiviral agent Antiviral agents assessment Bayesian framework calculated Chinese Chloroquine ClinicalTrials Cochrane Library Comparative coronavirus coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids COVID-19 cure cure rate development drug effect size Effectiveness Efficacy and safety eight evaluate Evidence followed by global pandemic health problem IFN include increased risk interferon interferons low dose measure moderate Mortality Negative conversion Network meta-analysis Odds ratio other treatments Patient patients with COVID-19 pharmacological intervention pharmacological interventions Primary outcome public health Randomized controlled trial Randomized controlled trials RCT RCTs reduce mortality reduction respiratory risk searched severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 standard care Standard of care systematic review TCM Traditional Chinese medicine Trial Viral was performed [DOI] 10.1097/CM9.0000000000001672 PMC 바로가기 [Article Type] Meta-Analysis
Projecting contact matrices in 177 geographical regions: An update and comparison with empirical data for the COVID-19 eraResearch Article Published on 2021-07-262022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, [키워드] age Analysis Bank conducted Contact country Coverage COVID-19 COVID-19 pandemic demographic division Effect Effectiveness eight element Europe European country feature Geographic difference geographical locations geographical region group groups household household size Infection Infectious disease interact Interaction Intervention lack majority mathematical mathematical model Model outbreak Pathogens physical distancing Population Public health responses quantified risk similarity social contact Spread structures subgroup transmitted [DOI] 10.1371/journal.pcbi.1009098 PMC 바로가기 [Article Type] Research Article
Comparative analysis of two molecular tests for the detection of COVID-19 in Cameroon카메룬에서 Covid-19의 검출을위한 두 분자 테스트의 비교 분석Comparative Study Published on 2021-07-262022-09-01 Journal: The Pan African Medical Journal [Category] 진단, [키워드] 24 hour 24 hours 95% confidence interval age AmpliQuick® SARS-CoV-2 Attitude Bayesian Cameroon Chain Reaction city classic clearance Comorbidity Comparative analysis conducted COVID-19 COVID-19 testing cross-sectional Da An Gene RT-PCR determine Diagnosis diagnostic District Douala drastic reduction eight enrolled ethical clearance ethics committee help Laboratory latent class male Molecular biology molecular test MOST nasopharyngeal sample nationality over parameter participant patients PCR performed polymerase chain polymerase chain reaction Prevalence profession rapid response reduced resolved Result RT-PCR SARS-CoV-2 sensitivity significant level situation study period test results the median Transcription university was performed were recorded [DOI] 10.11604/pamj.2021.39.214.30718 PMC 바로가기 [Article Type] Comparative Study
Development of a healthcare system COVID Hotspotting Score in California: an observational study with prospective validation캘리포니아의 의료 시스템 개발 COVID Hotspotting Score: 전향적 검증을 통한 관찰 연구Observational Study Published on 2021-07-262022-09-11 Journal: BMJ Open [Category] SARS, 임상, 치료기술, [키워드] collected correlated correlation correlations COVID COVID-19 development eight Health health informatics health system health systems healthcare Healthcare system highest hospital identify Metrics mitigate nine Observational data observational study occurred outcome positive COVID-19 public health quantified respiratory infection respiratory viral score setting variable [DOI] 10.1136/bmjopen-2020-048211 PMC 바로가기 [Article Type] Observational Study
Medical student wellness in the United States during the COVID-19 pandemic: a nationwide surveyResearch Published on 2021-07-262022-10-28 Journal: BMC Medical Education [Category] COVID-19, SARS, [키워드] Administered Anxiety Asian black can be used change coronavirus COVID-19 COVID-19 pandemic Decline Depression dimension dimensions eight emotional estimating equation expressed General population Generalized IMPROVE Intellectual less linear media medical education medical students mixed-effects model Monkey multivariable multivariable analysis pandemic physical public health crises reported response Result Satisfaction student supplementary material supported survey the United State unique United State wellness were used white [DOI] 10.1186/s12909-021-02837-y PMC 바로가기 [Article Type] Research
Automated machine learning optimizes and accelerates predictive modeling from COVID-19 high throughput datasets자동 기계 학습은 CovID-19 고역 처리량 데이터 세트의 예측 모델링을 최적화하고 가속화합니다.Article Published on 2021-07-232022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, [키워드] accelerate acute respiratory illness Analysis AUC Characteristics contribute COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients dataset datasets diagnostic disease effective eight feature Healthcare systems individuals Infectious diseases Innate interferon gamma machine learning management metabolomic mRNA Multiple nine Pathway analysis Pathways performed Predictive predictors prognostic proteomic public health reduced remained respiratory selected Signaling signature System therapeutic transcriptomic Viral [DOI] 10.1038/s41598-021-94501-0 PMC 바로가기 [Article Type] Article
Trends of follow-up clinic visits and admissions three-months before and during COVID-19 pandemic at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia: an interrupted time series analysisResearch Published on 2021-07-232022-10-28 Journal: BMC health services research [Category] COVID-19, SARS, [키워드] Admission adopted Analysis antiretroviral baseline Care clinics collected country COVID-19 COVID-19 case COVID-19 pandemic data extraction decrease Effect eight Ethiopia examined fluctuation Follow-up Follow-up visit genders Health healthcare Healthcare utilization hospital illnesses lockdown morbidity and mortality neurologic Non-COVID-19 patients pandemic Patient pediatric problem random renal Responding Result retrospective significant difference significantly lower Spread Treatment trend trends was used [DOI] 10.1186/s12913-021-06730-8 PMC 바로가기 [Article Type] Research