Identification and analysis of long non-coding RNAs and mRNAs in chicken macrophages infected with avian infectious bronchitis coronavirusResearch Article Published on 2021-01-202022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] addition Affect amino acid metabolism Analysis bronchitis cells cellular chicken competing coronavirus cultured cell differentially expressed down-regulated expression profile Factor Gga-miR-30d HD11 Host IBV IBV infection identification indicated Infectious Bronchitis Virus Innate immunity involved lncRNA Long long non-coding RNA Macrophage miR-146a-5p mRNA mRNAs non-coding RNA nucleic acid metabolism nucleotides Ontology Pathogenesis pathway enrichment provided Result RNA Sequencing subset supplementary material uninfected cells up-regulated viral infections [DOI] 10.1186/s12864-020-07359-3 PMC 바로가기 [Article Type] Research Article
Vitamin D Modulation of the Innate Immune Response to Paediatric Respiratory Pathogens Associated with Acute Lower Respiratory Infections비타민 D가 급성 하부 호흡기 감염과 관련된 소아 호흡기 병원체에 대한 선천 면역 반응 조절Review Published on 2021-01-192024-07-30 Journal: Nutrients [Category] 폐렴구균 감염증, [키워드] acute lower respiratory infections Influenza virus Innate immunity respiratory syncytial virus Streptococcus pneumoniae Vitamin D [DOI] 10.3390/nu13010276 PMC 바로가기 [Article Type] Review
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workersObservational Study Published on 2021-01-192022-10-05 Journal: The Journal of Clinical Investigation [Category] 임상, [키워드] acute respiratory syndrome age and sex Analysis anti-SARS-CoV-2 IgG BCG BCG vaccination Care caused Clinical characteristics clinical symptom Cohort collected coronavirus coronavirus disease COVID-19 death decrease determine develop Effects HCW HCWs Health Health care worker incidence Influenza information Innate Innate immunity Los Angele multisite nonspecific participant pneumococcal Prospective clinical trial Protective protective effect Questionnaires Randomized reported retrospective SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 seroprevalence Seroconversion Seroprevalence Therapeutic strategies vaccination Vaccine Vaccines [DOI] 10.1172/JCI145157 PMC 바로가기 [Article Type] Observational Study
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factorsReview Article Published on 2021-01-182023-08-30 Journal: Cellular and Molecular Immunology [Category] E형 간염, [키워드] Infection Innate immunity RIG-I-like receptors stress response Stress signalling viral infection [DOI] 10.1038/s41423-020-00602-7 PMC 바로가기 [Article Type] Review Article
CLIPB10 is a Terminal Protease in the Regulatory Network That Controls Melanization in the African Malaria Mosquito Anopheles gambiaeCLIPB10은 아프리카 말라리아 모기인 Anopheles gambiae의 멜라닌화를 조절하는 규제 네트워크의 말단 프로테아제입니다.Original Research Published on 2021-01-152024-08-08 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] Innate immunity melanization phenoloxidase serine protease serpin (serine proteinase inhibitor) [DOI] 10.3389/fcimb.2020.585986 PMC 바로가기 [Article Type] Original Research
The interplay between neutrophils, complement, and microthrombi in COVID-19Article Published on 2021-01-132023-06-16 Journal: Best practice & research. Clinical rheumatology [Category] MERS, SARS, [키워드] complement COVID-19 Innate immunity NETs Neutrophil extracellular traps SARS-CoV-2 thrombotic microangiopathy [DOI] 10.1016/j.berh.2021.101661 PMC 바로가기
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunityMetabolism Published on 2021-01-132022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] Activation activity ADP-ribose ADP-ribosylation antiviral activity antiviral responses biosynthetic boost cellular coronavirus Coronaviruses COVID-19 decrease demonstrated DNA damage ENhance enzyme expression expression of gene gene transcription host cell induce Infection Innate immunity interferon isozyme MHV murine hepatitis virus NAD biosynthesis NADP NAMPT nicotinamide nicotinamide adenine dinucleotide (NAD) nicotinamide riboside overexpression PARP PARP10 PARP12 PARP14 PARP7 Pathways pharmacological pharmacological intervention plus-stranded RNA virus poly(ADP-ribose) polymerase polymerase post-translational modification (PTM) Protein Replication RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 transcriptionally transcriptomics up-regulate [DOI] 10.1074/jbc.RA120.015138 PMC 바로가기 [Article Type] Metabolism
Immune memory: an evolutionary perspectiveLetter Published on 2021-01-122024-09-04 Journal: Human vaccines & immunotherapeutics [Category] 대상포진, [키워드] c.parvum corynebacterium parvum COVID-19 Innate immunity innate memory trained immunity [DOI] 10.1080/21645515.2020.1846396 PMC 바로가기 [Article Type] Letter
Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples여러 세포 모델 및 임상 샘플에서 SARS-CoV-2에 대한 호스트 미토콘드리아 전사체 반응Article Published on 2021-01-082022-09-10 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] analyzed BALF Cell cell lines cellular cellular respiration clinical sample clinical samples Complex I disrupt downregulated expression Gene Expression induce Infection innate immune response Innate immunity lung MAVS Mitochondria mitochondrial NEM Open reading frame open reading frames Other respiratory viruses polypeptide polypeptides primary cells Protein regulate respiratory respiratory viruses RNAseq RNAseq data SARS-CoV SARS-CoV-2 shown Signaling Transcriptome [DOI] 10.1038/s41598-020-79552-z PMC 바로가기 [Article Type] Article
Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2COVID-19 환자의 비인두 샘플 전사체 및 다른 SARS-CoV-2 감염 모델과의 비교 분석은 SARS-CoV-2에 대한 이질적인 숙주 반응을 보여줍니다Comparative Study Published on 2021-01-072022-09-10 Journal: Journal of Translational Medicine [Category] 변종, 유전자 메커니즘, [키워드] ACE2 Analysis Antigen presentation Apoptosis Atf3 CCL2 CCL4 CCR1 COVID-19 COVID-19 patient CXCL2 cytokine cytokine signaling disparate DPP4 effective enrichment analysis exhibited expressed expression feature Functional enrichment analyses GATA6 Genome variations genomic HDAC2 Host host response Host transcriptional response host transcriptome hypoxia IFN IL1A IL6 immune immune response immune system incorporation induction of apoptosis Innate immunity integrin Integrins interferon Invasion isolates ITGA2B ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAE ITGAV ITGB3 ITGB7 lung Lung injury Lungs Missense mutation nasopharyngeal cells nasopharyngeal sample Nasopharyngeal samples NFAT non-structural protein overexpression Pathogenesis patients progression protease reported response Result SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection TCF12 transcription factor transcription factors Transcriptome upregulation Viral viral pathogenesis Viral protein Viral proteins virus [DOI] 10.1186/s12967-020-02695-0 PMC 바로가기 [Article Type] Comparative Study