Polymorphism and Selection Pressure of SARS-CoV-2 Vaccine and Diagnostic Antigens: Implications for Immune Evasion and Serologic Diagnostic PerformanceArticle Published on 2020-07-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Antigen antigenic drift antigens clade conservation coronavirus Critical diagnostic diversifying selection Diversity Efficacy effort evaluated Frequency glycoprotein immune evasion MOST performance Phylogenetic pressure Protective regions S antigen SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 pandemic Selection selection pressure sequence serologic serological test Significant Spread the Spike triggered Vaccine Vaccine development variant Viral protein viral strain [DOI] 10.3390/pathogens9070584 PMC 바로가기 [Article Type] Article
Temperature Sensitivity: A Potential Method for the Generation of Vaccines against the Avian Coronavirus Infectious Bronchitis VirusArticle Published on 2020-07-142022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Accessory genes affected allelic antigenic clone contagious core body temperature coronavirus days post infection defined determinant determine dissemination effectively deliver eyelid function Generation Genes genetics Host IBV in vivo Infectious Bronchitis Virus investigated lesion molecular mRNA synthesis Mutation pathogenic Potential Proteins replicase replicate respiratory pathogen RNA synthesis sensitivity Seven strain temperature temperature sensitive temperature sensitivity tissue upper respiratory tract Vaccine design Vaccine development vaccine platform viral replication was used [DOI] 10.3390/v12070754 PMC 바로가기 [Article Type] Article
Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19 Research Published on 2020-07-132022-10-05 Journal: Nature Medicine [Category] 바이오마커, 변종, 임상, 치료기술, [키워드] acute respiratory syndrome angiotensin-converting enzyme 2 B cell Biomarker cellular receptor characterized circulating coronavirus coronavirus disease COVID-19 effective elicited Eliciting follicular Frequency glycoprotein hallmark helper T cell Human humoral Humoral immunity immune Immunity immunogenic membrane memory B cell Neutralizing activity neutralizing antibody neutralizing epitopes neutralizing responses pandemic Patient phenotype plasma Prevent Receptor binding domain recovered patient resolved response robust S-based vaccine S-specific antibodies SARS-CoV-2 SARS-COV-2 infection subject Vaccine Vaccine development virion with COVID-19 [DOI] 10.1038/s41591-020-0995-0 [Article Type] Research
Energetics and IC50 based epitope screening in SARS CoV-2 (COVID 19) spike protein by immunoinformatic analysis implicating for a suitable vaccine developmentResearch Published on 2020-07-102022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] ACE-2 receptor protein ACE2 Analysis antigenicity binding conserved COVID 19 database develop domain Effect Effects energetics epitope Epitope designing and screening extreme genetic material glycoprotein glycosylation Health Host IC50 inhibitor manifested MERS-CoV MHC II motif mutations Ontology outbreak PyMol reactivity regimen Region Result SARS CoV SARS CoV-2 SARS CoV-2 (COVID 19) SARS-CoV SARS-CoV-2 screened selected server Severe global outbreak-Dec 2019 spike glycoprotein Spike protein stability the SARS-CoV-2 therapeutic Topology vaccination Vaccination strategy Vaccine Vaccine development viral spike virulence ZDOCK [DOI] 10.1186/s12967-020-02435-4 PMC 바로가기 [Article Type] Research
Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2Short Report Published on 2020-07-102022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, SARS, [키워드] Analysis antigenicity B-cell epitope B-cell epitopes BepiPred binding bioinformatics Bioinformatics analysis Biotechnology candidate caused center characterized component computation database Discontinuous epitope Epitope-based vaccine exhibited feature genome sequence Gln HLA binding IEDB immune Infection MHC class MHC class I NCBI nucleocapsid protein outbreak pandemic peptide predict predicted Pro produced Protective protein sequence public health Rapid residue resource Result retrieved SARS-CoV-2 spike Spike protein surface T-cell epitope Thr Vaccine Vaccine development [DOI] 10.1186/s40249-020-00713-3 PMC 바로가기 [Article Type] Short Report
The early landscape of coronavirus disease 2019 vaccine development in the UK and rest of the worldReview Article Published on 2020-07-082022-10-30 Journal: Immunology [Category] COVID-19, [키워드] accelerated acute respiratory syndrome caused clinical trial conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 death develop Diseases effective genome sequence Infection lifted lockdown measure pandemic Phase I platform Prevent progressed Public health intervention Respiratory disease responsible SARS‐CoV‐2 severe acute respiratory syndrome coronavirus‐2 timeline Vaccine vaccine candidate Vaccine development Vaccines World Health Organization [DOI] 10.1111/imm.13222 PMC 바로가기 [Article Type] Review Article
Implications of SARS-CoV-2 Mutations for Genomic RNA Structure and Host microRNA TargetingArticle Published on 2020-07-072022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] addition Affect Alter amino acid changes analysed cardiovascular disease changes in conserved conserved mutation Critical expressed Genome genomic globe host cells host miRNA host miRNAs human host humans interfere introduced microRNA miRNA miRNA target Mutation mutations offer overexpressed pathogen Pathogenesis Patient platform predicted Replication RNA RNA secondary structure SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 isolate SARS-CoV-2 replication SARS-CoV-2 virus secondary structure secondary structures sequence splice site Structure subset target targeting the SARS-CoV-2 Transmission Vaccine development viral fitness viral life cycle viral tropism zoonotic [DOI] 10.3390/ijms21134807 PMC 바로가기 [Article Type] Article
Recent insights for the emerging COVID-19: Drug discovery, therapeutic options and vaccine developmentReview Published on 2020-07-042023-08-30 Journal: Asian Journal of Pharmaceutical Sciences [Category] E형 간염, [키워드] coronavirus COVID-19 Drug discovery Precise prevention and control SARS-CoV-2 Vaccine development [DOI] 10.1016/j.ajps.2020.06.001 PMC 바로가기 [Article Type] Review
COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning역백신학 및 기계 학습을 사용한 COVID-19 코로나바이러스 백신 설계Immunology Published on 2020-07-032022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 비임상, [키워드] adhesins Analysis antigenicity applied breath Candidates caused clinical trial complementary Complete conserved contagious contagious disease coronavirus coronavirus vaccine COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine development develop disease effective Epitopes FIVE Host human coronavirus immune responses induce infecting Invasion lack linear B-cell epitope linear B-cell epitopes machine learning membrane MERS MERS-CoV MHC-I MHC-II mild symptoms N protein non-structural protein non-structural protein 3 non-structural proteins NSP Nsp3 NSP8 nucleocapsid predict predicted Protective Protein Proteins proteome reverse vaccinology S protein Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus sequence stimulate structural protein T-cell epitopes target tested the S protein the SARS-CoV-2 Vaccine vaccine candidate Vaccine development vaxign vaxign-ML Viral virus was selected [DOI] 10.3389/fimmu.2020.01581 PMC 바로가기 [Article Type] Immunology
The Potential Vaccine Component for COVID-19: A Comprehensive Review of Global Vaccine Development EffortsInternal Medicine Published on 2020-06-272022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome available data caused cell receptor clinical trial component Comprehensive coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 vaccines deaths development DNA effective fatality Interaction International pandemic positive Potential public health emergency review SARS-CoV-2 Treatment Trial unmet need Vaccine Vaccine development [DOI] 10.7759/cureus.8871 PMC 바로가기 [Article Type] Internal Medicine