Repositioning HIV protease inhibitors and nucleos(t)ide RNA polymerase inhibitors for the treatment of SARS-CoV-2 infection and COVID-19SARS-CoV-2 감염 및 COVID-19 치료를 위한 HIV 프로테아제 억제제 및 뉴클레오타이드 RNA 폴리머라제 억제제 재배치Review Published on 2021-03-042022-08-31 Journal: European Journal of Clinical Pharmacology [Category] SARS, 신약개발, 임상, 치료제, [키워드] addition antiretroviral Antiviral treatment approved approved drug candidate Candidates Clinical studies clinical study clinical trial clinical trials clinician Cobicistat compounds COVID-19 darunavir darunavir/cobicistat drug drugs evaluate evaluated Favipiravir followed by high variability HIV protease inhibitor HIV protease inhibitors Hospitalization indications inhibitors lack Lopinavir Lopinavir/ritonavir MERS Mortality pandemic Prevalence Protease inhibitor protease inhibitors question Remdesivir repositioning Repositioning drugs Research Result Ritonavir RNA polymerase RNA polymerase inhibitor RNA polymerase inhibitors RNA virus SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pandemic single-stranded RNA virus sofosbuvir Study design Taking target tenofovir the SARS-CoV-2 therapeutic options Therapeutics Treatment treatment of COVID-19 Vaccine [DOI] 10.1007/s00228-021-03108-x PMC 바로가기 [Article Type] Review
Preferences for Artificial Intelligence Clinicians Before and During the COVID-19 Pandemic: Discrete Choice Experiment and Propensity Score Matching StudyOriginal Paper Published on 2021-03-022022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS, [키워드] 95% CI Accuracy affected Analysis artificial artificial intelligence attribute can be used Care caused changes in choice clinical diagnose clinician clinician diagnosis COVID-19 COVID-19 pandemic demographic characteristics diagnose diagnoses Diagnosis Discrete discrete choice discrete latent traits female group Health high accuracy intelligence latent class logit male matching objective Odds ratio pandemic Patient Patients’ preferences preference propensity score matching public health questionnaire receive receiving recruited remained resource respondent Result score Sex stratified Traditional medicine were used [DOI] 10.2196/26997 PMC 바로가기 [Article Type] Original Paper
Diagnostic value of cutaneous manifestation of SARS‐CoV‐2 infectionEpidemiology Published on 2021-03-022022-10-28 Journal: The British journal of dermatology [Category] COVID-19, SARS, [키워드] 95% confidence interval assist association chilblain classical clinician Cluster conducted COVID COVID‐19 COVID‐19 symptoms cutaneous manifestation diagnosing Diagnosis diagnostic value evaluate form Healthcare professional help hospital include independent individual lesion less manifestation multisystemic disease objective occur Odds ratio Patient positive swab Predictive Rash rashe rashes reported Result SARS‐CoV‐2 infection skin skin rash skin rashe skin rashes Spread Symptom Symptoms the disease used data website [DOI] 10.1111/bjd.19807 PMC 바로가기 [Article Type] Epidemiology
A pharmacological framework for integrating treating the host, drug repurposing and the damage response framework in COVID-19COVID-19에서 숙주 치료, 약물 용도 변경 및 손상 대응 프레임워크를 통합하기 위한 약리학적 프레임워크Review Published on 2021-03-012022-08-31 Journal: British Journal of Clinical Pharmacology [Category] 신약개발, 치료제, [키워드] absence Analysis angiotensin antiviral drugs antiviral therapeutics approach approaches clinical pharmacology clinician conserved COVID-19 damage response framework defined disease dose dose and safety dysregulated effective Elimination framework Government homology Host increasingly infective agent information innate immune innate immune system integration locus mapped novel antiviral drug novel antiviral drugs Observational data outcome Pandemics Pathogenesis pathophysiological pathway patients pharmacological Renin renin angiotensin system renin-angiotensin system repurposing Research reveal severe disease Spectrum target homology the disease therapeutic therapeutic repurposing Therapeutics therapy treating the host. Treatment Vaccine Vaccines Viral virus viruses void [DOI] 10.1111/bcp.14551 PMC 바로가기 [Article Type] Review
Fast and cost-effective screening for SARS-CoV-2 variants in a routine diagnostic setting일상적인 진단 환경에서 SARS-CoV-2 변이체에 대한 빠르고 비용 효율적인 스크리닝Article Published on 2021-03-012022-09-11 Journal: Dental materials : official publication of the Aca [Category] SARS, 변종, [키워드] amplification B1.351 clinician described diagnostic health authorities indications information Mutation N501Y PCR performed positive Positive test prevalent public health authorities public health authority qPCR Randomly Receptor binding domain SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 variant screened screening procedure selected South South Africa United Kingdom variant wildtype [DOI] 10.1016/j.dental.2021.01.015 PMC 바로가기 [Article Type] Article
Estimation of the uncertainty of values assigned to calibration materials prepared in-house: An example for hydroxychloroquine calibrators in blood-hemolysate-based matrix자체적으로 준비한 보정 재료에 할당된 값의 불확실성 추정: 혈액 용혈액 기반 매트릭스의 하이드록시클로로퀸 보정기의 예Article Published on 2021-03-012022-09-12 Journal: Clinical biochemistry [Category] SARS, 진단, [키워드] antimalarial approach assigned assist biological fluids Bottom-up approach calculated calibration Calibration materials calibrator clinician concentration of hydroxychloroquine estimation example Final HPLC Hydroxychloroquine Infection Laboratory measurement Measurement uncertainty. patients with COVID-19 pharmacological quantified resulting Treatment was used [DOI] 10.1016/j.clinbiochem.2021.01.005 PMC 바로가기 [Article Type] Article
Carotid Artery Dissection and Hemorrhagic Stroke in the Setting of Multisystem Inflammatory Syndrome in ChildrenAnesthesiology Published on 2021-03-012022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Admission Artery carotid children clinician coronavirus 2 COVID-19 Dissection eight extracorporeal membrane oxygenation Features ganglia global pandemic healthy children Hemorrhagic Stroke Hospitalized ICU Infection Inflammatory Inflammatory response intensive care MIS-C New York City non-traumatic carotid artery dissection Patient pediatric pediatric anesthesiology positive presenting reported respiratory SARS-CoV-2 setting subsequent syndrome thought United Kingdom [DOI] 10.7759/cureus.13640 PMC 바로가기 [Article Type] Anesthesiology
Could ferritin level be an indicator of COVID-19 disease mortality?페리틴 수치가 COVID-19 질병 사망률의 지표가 될 수 있습니까?Article Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission age blood test blood tests can be used cause caused chemokine clinician control group coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 disease cytokine Cytokine storm cytokine/chemokine died discharge evaluated ferritin hematological high mortality hospital Hospitalized immune immune system Inflammation information Inpatients Laboratory laboratory data laboratory findings level of significance management marker Mortality no significant difference Pandemics Patient predict progression respiratory Serum ferritin serum ferritin level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly higher study group the disease the mean the patient the study group two group two groups while widespread [DOI] 10.1002/jmv.26543 PMC 바로가기 [Article Type] Article
Recommendations for Dosing of Repurposed COVID-19 Medications in Patients with Renal and Hepatic Impairment신장 및 간 장애 환자의 용도 변경 COVID-19 약물 투여에 대한 권장 사항Review Published on 2021-03-012022-09-11 Journal: Drugs in R&D [Category] MERS, 신약개발, 임상, 치료제, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Altered Anakinra anticipated Antiviral Atazanavir available data Azithromycin clinician complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 in patient Dexamethasone Dosing drug drug concentration drug concentrations drug interaction Efficacy excretion experimental drug Experimental drugs Favipiravir Guidance hepatic hepatic disease hepatic function hepatic impairment Hydroxychloroquine immune indications Injury interferon beta Limited Lopinavir Lopinavir/ritonavir medication medications metabolism outbreak Patient patients with COVID-19 pharmacokinetic pharmacokinetics produced recommendation reduced regimen Remdesivir renal renal or hepatic impairment respiratory resulting ribavirin Ritonavir sarilumab SARS-CoV-2 significantly therapy Tocilizumab toxicities Toxicity treat Treatment treatment for COVID-19 Trial University of Liverpool Variability was performed website [DOI] 10.1007/s40268-020-00333-0 PMC 바로가기 [Article Type] Review
Re-purposed antiviral drugs without a purpose in COVID-19: a valuable lesson for cliniciansCOVID-19에서 목적 없는 용도 변경 항바이러스제: 임상의를 위한 귀중한 교훈Review Published on 2021-03-012022-09-11 Journal: European heart journal [Category] Fulltext, SARS, 신약개발, 치료제, [키워드] antiviral drug clinician [DOI] 10.1093/eurheartj/ehab043 PMC 바로가기 [Article Type] Review