followed by – Page 66 – Communicable Diseases Research

Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: a randomised, double-blind, placebo-controlled trial

남아프리카 공화국의 유아 및 유아에 대한 비경구 P2-VP8-P[8] 서브유닛 로타바이러스 백신의 안전성 및 면역원성: 무작위, 이중 맹검, 위약 대조 시험

Articles

Published on 2017-05-052022-09-06
Journal: The Lancet. Infectious Diseases
[Category] Communicable Disease,

[키워드] 95% CI adjusted adverse event adverse events African approach assigned benefit block Block randomisation Cohort computer-generated different dose different doses dose dose-escalation doses double-blind eligible Endpoint enrolled finding FIVE followed by foundation Frequency funding geometric mean geometric mean titre geometric mean titres groups healthy highest HIV-uninfected homologous hospital IgA IgG IgG seroresponse immunogenic immunogenicity Infant Infants injection Injections Laboratory live oral rotavirus vaccines Local Melinda Gate Melinda Gates Mild neutralising antibody neutralising antibody seroresponse neutralising antibody seroresponses nine non-replicating rotavirus vaccine occurred offer oral rotavirus vaccine oral vaccines parent Parenteral parents participant Placebo placebo group placebo-controlled placebo-controlled trial primary immunogenicity randomisation randomised reaction receiving reduced Registered Research rotavirus rotavirus disease rotavirus vaccination rotavirus vaccine Safety safety analysis safety endpoint Serious Adverse Event Serious Adverse Events Serum IgA seroresponse Serum IgA seroresponses Seven severity South South Africa subunit Subunit vaccine systemic reaction systemic reactions the placebo group those receiving placebo Treatment Trial trivalent vaccination Vaccine was done was used
[DOI] 10.1016/S1473-3099(17)30242-6 PMC 바로가기 [Article Type] Articles

Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends

텔로미어의 Ku 결합은 물리적 염색체 말단에서 먼 부위에서 발생

Research Article

Published on 2016-12-082022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

Heterozygous De Novo and Inherited Mutations in the Smooth Muscle Actin ( ACTG2 ) Gene Underlie Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome

평활근 액틴(ACTG2) 유전자의 이형 접합체 및 유전 돌연변이는 거대포낭-소결장-장 연동운동부전 증후군의 기초가 됩니다.

Research Article

Published on 2014-03-272022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] abdominal surgeries abdominal surgery ACTG2 Actin Actins affected affecting arginine arginine residues bladder catheterization codon Cohort cohort of patient component components contractile protein contractile proteins CpG de novo mutation de novo mutations dependent on described description diagnosed dinucleotide disease disorder DNA ENCODE enteric smooth muscle Families Finnish followed by food gastrointestinal problem gastrointestinal problems Genes heterozygous heterozygous mutation Hypoperistalsis identify initial intestinal intestinal pseudo-obstruction intestine less majority megacystis megacystis-microcolon-intestinal hypoperistalsis syndrome microcolon Missense mutation Missense mutations missense variant MMIHS muscle muscle contractile units muscle disease Muscle function Mutation mutations obstruction organ parenteral nutrition Patient patients phenotype powerful tool provide radiologist remained responsible Sanger sequencing Smooth smooth muscle smooth muscle disease Spectrum subjects syndrome the disease total parenteral nutrition Treatment unique urinary catheterization variant visceral whole-exome sequencing γ2 enteric actin
[DOI] 10.1371/journal.pgen.1004258 PMC 바로가기 [Article Type] Research Article

Classic Selective Sweeps Revealed by Massive Sequencing in Cattle

소에서 대규모 시퀀싱으로 밝혀진 클래식 선택적 스윕

Research Article

Published on 2014-02-272022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major affected affecting allele among others analysis ancestors applied approach association autosomal SNP candidate gene cattle classic CLR complementary complexity Composite current detect detectable disequilibrium Domestication ERBB4 Evidence faster fixation Fleckvieh followed by Genetic genetics Genome genome-wide association genomic genomic region help homozygosity Human identify iHS IMPROVE KIT life style likelihood ratio linkage Linkage disequilibrium massive MC1R MITF multiple statistical metrics NRG4 overlap Perspective phenotype Phenotypes physical Protein QTL mapping QTLs Ratio re-sequencing Region regions Result Revealed score sensory perception Sequencing sequencing technology significantly somatic cell somatic cell count speciation subsequent TAS2R16 temper thought TMEM132D traits utility whole genome Whole genome sequencing
[DOI] 10.1371/journal.pgen.1004148 PMC 바로가기 [Article Type] Research Article

Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors

원추형 광수용체에서 Ranbp2의 특정 제거 시 광수용체 세포 유형 간의 고유하고 비정형적인 고유 및 외인성 세포 사멸 경로

Research Article

Published on 2013-06-202022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Ablation Activation acute transverse myelitis affecting Apoptosis approaches arise Author base cascade caspase caspase-3 caspase-7 caspase-9 cause Cell cell death clinical manifestations cone cone photoreceptor contribute death degenerate degeneration demise develop Diseases disintegration downstream driving event expression extrinsic Factor followed by found Gene Genes Genetic genetic defect hallmark healthy heterogeneous implicated intrinsic intrinsically manifestation mechanism membrane permeability metalloproteinase modulation molecular mosaic multifunctional protein Mutation Myelitis necrotic neural retina neurodegeneration neurodegenerative neurodegenerative disorders Neuron neurons neuroprotection PARP1 pathway Pathways photoreceptor photoreceptors pleiotropic progression progression of disease promote Protein Ranbp2 rod rod photoreceptor rod photoreceptors rods spatiotemporal Specific Stressor subcellular therapeutic thought transverse myelitis Trigger triggered Tumor Type undergo underlying disease underlying diseases up-regulation
[DOI] 10.1371/journal.pgen.1003555 PMC 바로가기 [Article Type] Research Article