immune responses – Page 66 – Communicable Diseases Research

Highly feasible immunoprotective multicistronic SARS-CoV-2 vaccine candidate blending novel eukaryotic expression and Salmonella bactofection

새로운 진핵생물 발현과 살모넬라 박토펙션을 혼합한 매우 실현 가능한 면역보호 멀티시스트론 SARS-CoV-2 백신 후보

Article

Published on 2021-07-222022-09-11
Journal: Journal of advanced research [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,

Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine elicits T-cell and antibody responses in mice

이중 항원 코비드 -19 백신을 사용한 비강 + 피하 주요 예방 접종은 마우스에서 T- 세포 및 항체 반응을 유도한다.

Article

Published on 2021-07-212022-09-01
Journal: Scientific Reports [Category] SARS, 진단, 치료기술, 치료법,

Longitudinal Serology of SARS-CoV-2-Infected Individuals in India: A Prospective Cohort Study

인도에서 SARS-COV-2- 감염된 개인의 종단 혈청학 : 전향 적 코호트 연구

Articles

Published on 2021-07-182022-09-10
Journal: The American Journal of Tropical Medicine and Hygi [Category] SARS, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 All participant All participants Antigen Asia Asymptomatic Capital Capital Region Characteristics clinical cohorts comparable convalescence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 epidemiological highlight humoral immune response IgG IgG antibodies IgG antibody immune responses Immunoglobulin Immunoglobulin G immunological characteristics India individual Infection longitudinal Mild mild to moderate moderate multivariable Multivariable regression analysis nasopharyngeal viral nucleocapsid participant positive individuals Postinfection predictor proportion Prospective prospective cohort RBD RBD antigen Receptor binding domain Region regression analysis respiratory response RNA RT-PCR RT-PCR SARS-CoV-2 SARS-CoV-2-positive individual Seroconversion seroconversion rate seroconversion rates serological response serology Seropositivity Serosurveys severe acute respiratory syndrome Coronavirus severe disease severity South subset symptomatic the RBD threshold value Viral were assessed
[DOI] 10.4269/ajtmh.21-0164 PMC 바로가기 [Article Type] Articles

SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescence

SARS-COV-2- 특이 적 순환 T 여포 헬퍼 세포는 중화 항체와 관련이 있으며 조기 회복기 동안 증가합니다.

Research Article

Published on 2021-07-162022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, SARS, 진단, 치료기술, 치료법,

[키워드] addition Antibody neutralization Antigen approved assist Blood caused CD4 T cells CD4 T-cell Cell circulating contribute convalescence convalescent convalescent individuals coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 CXCR5 declined defined detectable examined follicular Frequency generate greater helper cells helping immune response immune responses individual Infection M protein magnitude majority median morbidity and mortality mounted N protein Neutralizing antibodies neutralizing antibody neutralizing antibody responses pandemic PD1 post-symptom onset PROTECT Protein response responses responses against robust S protein SARS-CoV-2 SARS-COV-2 infection specificity Spike protein structural protein structural proteins subset symptom onset T cells T cells) T follicular helper cells T-cell immunity T-cell Response T-cell responses Tfh the spike protein the strongest These cells These data Vaccine
[DOI] 10.1371/journal.ppat.1009761 PMC 바로가기 [Article Type] Research Article

Comprehensive Deep Mutational Scanning Reveals the Immune-Escaping Hotspots of SARS-CoV-2 Receptor-Binding Domain Targeting Neutralizing Antibodies

Microbiology

Published on 2021-07-152022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] ACE2 addition Analysis angiotensin-converting enzyme 2 antibodies antibody benefit binding binding stability Care caused clinically comparable Comprehensive COVID-19 COVID-19 pandemic Critical deep demonstrated Depression Effect Evolution F486 hotspot Hotspots Human immune system immune responses Immunity impairing information Interaction investigated K417 L455 Mutation mutations neutralization Neutralizing Neutralizing antibodies neutralizing antibody observation predict Q493 RBD RBD variant residue resulting SARS-CoV-2 scanning Spread targeting the RBD the receptor-binding domain Vaccine variant variants of SARS-CoV-2 Y449
[DOI] 10.3389/fmicb.2021.698365 PMC 바로가기 [Article Type] Microbiology

Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier

어린이의 다기관 염증 증후군은 장 점막 장벽의 조눌린 의존성 상실에 의해 유발됩니다

Article

Published on 2021-07-152022-09-11
Journal: The Journal of Clinical Investigation [Category] Coronavirus, SARS, 바이오마커, 치료기술, 치료제,

[키워드] acute COVID-19 analyzed Antigen antigen detection antigenemia Biomarker biospecimen biospecimens bloodstream breakdown Cardiac complications characterized children children with MIS-C Clinical improvement controls COVID-19 decrease develop diagnosing disease driven by examined Gastrointestinal GI Tract Gut hyperinflammation Hyperinflammatory immune response immune responses increasingly Inflammation Inflammatory Inflammatory marker inflammatory markers intestinal permeability junctions larazotide life-threatening marker mechanistic data MIS-C mucosal mucosal barrier Pathogenesis Patient plasma probe proof proof of concept reverse transcription PCR RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 spike antigen stools subsequent Symptom syndrome target targets the patient tight junctions treated was used were assessed
[DOI] 10.1172/JCI149633 PMC 바로가기 [Article Type] Article

Safety and immunogenicity of a recombinant COVID-19 vaccine (Sf9 cells) in healthy population aged 18 years or older: two single-center, randomised, double-blind, placebo-controlled, phase 1 and phase 2 trials

18 세 이상의 건강한 인구에서 재조합 코비드 -19 백신 (SF9 세포)의 안전성 및 면역 원성 : 2 개의 단일 센터, 무작위, 이중 맹검, 위약 대조, 1 상 및 2 상 시험의 안전성 및 면역 원성

Clinical Trial

Published on 2021-07-152022-08-13
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 임상,

[키워드] (phase 1 (phase 2 (phase 2) 95% CI Adverse reaction Adverse reactions antibody assigned candidate vaccine China cough COVID-19 vaccine COVID-19 vaccines dose double-blind Eligible participants ELISA enrolled fatigue Fever GMT GMTs headache healthy High dose high dose vaccine highest immune response immune responses immunogenicity injection live SARS-CoV-2 low dose vaccine Neutralising Antibodies neutralising antibody Older Pain participant peaked Phase 1 phase 1 trial Phase 2 phase 2 trial Placebo placebo-controlled problem randomised Randomly receive recombinant COVID-19 vaccine Safe Safety schedule Sf9 cells single-center sore throat Specific Specific T-cell response T-cell Response Tolerability Trial trials vaccination Vaccine Vaccines
[DOI] 10.1038/s41392-021-00692-3 PMC 바로가기 [Article Type] Clinical Trial

A Combination of N and S Antigens With IgA and IgG Measurement Strengthens the Accuracy of SARS-CoV-2 Serodiagnostics

N 및 S 항원과 IgA 및 IgG 측정의 조합으로 SARS-CoV-2 혈청 진단의 정확성 강화

Major Articles and Brief Reports

Published on 2021-07-152022-09-10
Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, 치료법,

[키워드] 229E acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis antibodies antibody Antigen antigens Combination convalescent phase coronavirus coronavirus proteins correlation COVID-19 COVID-19 patient COVID-19 patients CoVs diagnostics enzyme enzyme immunoassay enzyme immunoassays estimates human CoVs humoral immune response humoral immune responses Humoral immunity IgA IgG IgM immune response immune responses immunoassay Immunoglobulin in viral increase Infection measurement MERS Microneutralization test Middle East Middle East respiratory syndrome N protein N proteins Nasopharyngeal swab Nasopharyngeal swab samples Neutralizing antibodies NL63 primary diagnosis provide RBD Receptor binding domain respiratory respiratory infection Result S antigen SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 S1 sensitivity sera serological serology Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly increased Spike protein syndrome test results Viral viral spike protein virus RNA were used
[DOI] 10.1093/infdis/jiab222 PMC 바로가기 [Article Type] Major Articles and Brief Reports

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

인터페론-무기 RBD 이량 체는 SARS-COV-2에 대한 멸균 면역을위한 RBD의 면역 원성을 향상시킨다.

Clinical Trial

Published on 2021-07-152022-08-13
Journal: Cell Research [Category] Fulltext, SARS, 비임상, 임상, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjuvant Adults antigen processing antiviral immune responses appear Biological techniques breath caused Complete coronavirus COVID-19 dimerized DLNs draining lymph node effort elicit ENhance healthy High-dose human I-P-R-F vaccine I-P-R-F I-R-F immune responses Immunity Immunoglobulin induce initiated Innate immunity interferon long-lasting long-lasting neutralizing antibodies long-lasting neutralizing antibody low dose Lower respiratory tract lymph nodes NAbs overcome placebo-controlled protective immunity provide Randomized RBD RBD dimer Receptor-binding domain respiratory rhesus macaques Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell response the receptor-binding domain the vaccine Trial Trigger upper and lower respiratory tracts V-01 vaccination Vaccine vaccine candidate
[DOI] 10.1038/s41422-021-00531-8 PMC 바로가기 [Article Type] Clinical Trial

SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney

시리아 햄스터 모델의 SARS-COV-2 감염은 심장과 신장을 포함한 호흡기 및 비-자극 조직 모두에서 I 형 INTERFERON DYSREGUM뿐만 아니라 염증을 유발합니다.

Research Article

Published on 2021-07-152022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, SARS,

[키워드] (coronavirus disease 2019 acute respiratory syndrome Affect affecting antiviral cytokine antiviral cytokines antiviral response captures cardiovascular system cause caused clinical symptom coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines damage disease dysregulation evaluate Evidence evidence of examination extrapulmonary tissue hamsters heart host response host responses IL-1beta IL-6 immune host response immune responses indicated Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibited interferon interferons investigated kidney kidneys liver microthrombi multiorgan disease myocarditis neurological system non-respiratory tissue occur organ system organ systems PASC people with COVID-19 prolonged disease regulated required respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity significant increases in Symptom Therapeutics TNF tubular inflammation type I interferon type I interferons type II interferon type II interferons upregulation Urinary tract Viral viral infection with infection
[DOI] 10.1371/journal.ppat.1009705 PMC 바로가기 [Article Type] Research Article