Randomized Controlled Trial of a Mobile Health Intervention to Promote Retention and Adherence to Preexposure Prophylaxis Among Young People at Risk for Human Immunodeficiency Virus: The EPIC Study인간 면역 결핍 바이러스의 위험이 있는 젊은이들 사이에서 노출 전 예방에 대한 유지 및 준수를 촉진하기 위한 모바일 건강 중재의 무작위 대조 시험: EPIC 연구Articles and Commentaries Published on 2019-06-152022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 95% CI 95% confidence interval acquisition adherence age bidirectional Blood clinical Concentration conducted Controlled demonstrated doses drug levels Effectiveness Efficacy enrolled EpiC evaluate evaluated HIV Human Human immunodeficiency virus immunodeficiency virus individual Infection insurance Intervention Latino Logistic men men who have sex with men (MSM) Mobile not differ Odds ratio outcome participant preexposure prophylaxis preexposure prophylaxis (PrEP) PrEP Prophylaxis Randomized Randomized controlled trial receive Registration reported Result retention risk robust Sex significantly significantly increased SOC Standard of care study visit tenofovir tenofovir diphosphate text-messaging TFV-DP Youth [DOI] 10.1093/cid/ciy810 PMC 바로가기 [Article Type] Articles and Commentaries
UBXN1 interacts with the S1 protein of transmissible gastroenteritis coronavirus and plays a role in viral replicationResearch Article Published on 2019-04-272022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] Antiviral binding cause cDNA library Cell cells clone coronavirus Degradation diarrhea downregulated expression expression level gastroenteritis glycoprotein GST host receptor identify IFN-β in viral indicated Infection inhibition interact intestinal cell intracellular protein involved late phase morbidity and mortality negative control overexpression positive Protein protein domain protein synthesis provided regulate Replication Research responsible Sequencing sialic acid Signal transduction signaling pathways significantly significantly increased siRNA TGEV the S1 protein UBXN1 viral titer yeast [DOI] 10.1186/s13567-019-0648-9 PMC 바로가기 [Article Type] Research Article
Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn pigletsResearch Articles Published on 2019-02-262022-10-28 Journal: Bioscience Reports [Category] Coronavirus, MERS, [키워드] administration antibody Antigen B. subtilis Bacillus subtilis candidate vaccine cause CD3 CD4 cells COE Contact contagious demonstrated develop disease effective epidemic diarrhea evaluated expressing IgA IgG immune immune response immunization Immunoglobulin immunoglobulin A Infection Local lymphocyte mucosal mucosal immune mucosal immunity Newborn oral administration Oral vaccine PEDV Peyer’s patche Piglets Porcine epidemic diarrhea virus prevented recombinant Bacillus subtilis responses secreting serum SIgA significantly significantly increased Spread systemic immune response T cells up-regulated Vaccine Vaccines virus [DOI] 10.1042/BSR20182028 PMC 바로가기 [Article Type] Research Articles
Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathwayCek1 경로의 활성화에 의해 칸디다 알비칸스 β(1,3)-글루칸의 노출이 촉진됩니다Research Article Published on 2019-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation addition AIDS antigenic approach biogenesis bloodstream Cancer patients Candida Candida albican Candida albicans cascades cause Cdc42 Cell cell wall cell wall synthesis decrease detect disrupt Disruption downstream drug exhibit exposure Fungal infection fungal infections fungal pathogens glucan glycosylated GTPase homozygous Hyperactivation immune immune cells immune function immune system increase independent innate immune cell Innate immune cells Intracellular kinase kinases lab lead leads mannan MAPK masking mitogen Mortality mutant Mutation Pathogens pathway Patient Phosphatidylserine polysaccharide promoted protein kinase receptor receptors regulate remodeling responsible Signaling signaling cascade significantly increased synthesis the cell up-regulated upregulated upregulation upstream virulence virulence factor weakened were used wild-type wild-type cell wild-type cells [DOI] 10.1371/journal.pgen.1007892 PMC 바로가기 [Article Type] Research Article
Single Chain Fragment Variable (scFv) Antibodies Targeting the Spike Protein of Porcine Epidemic Diarrhea Virus Provide Protection against Viral Infection in PigletsArticle Published on 2019-01-142022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Administered administration antibody Antigen cause chain cloned contagious coronavirus death diarrhea effective epidemic diarrhea epitope expression fragment higher affinity IFA Infection inhibit intestinal investigated lesions less mild clinical symptoms Mortality Neonatal neutralizing antibody passive immunization PEDV plaque reduction neutralization Plasmid Porcine epidemic diarrhea virus protection protein expression scFv screened selected shown significantly significantly increased single chain fragment variable (scFv) spike (S) protein Support survival rate targeting the Spike the spike protein Treatment variable viral shedding virus [DOI] 10.3390/v11010058 PMC 바로가기 [Article Type] Article
Oral administration of inactivated porcine epidemic diarrhea virus activate DCs in porcine Peyer’s patchesResearch Article Published on 2018-08-162022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] activate adaptive administration Allogeneic antibody Antigen Cell contagious DCs dendritic cell dendritic cells epidemic diarrhea Gut IgA IgG antibody IL-1 IL-4 immune immune response Immunity inactivated Inactivated porcine epidemic diarrhea virus Interaction intestinal intestine investigated Lymphocytes mucosal oral administration PEDV Peyer’s patche Peyer’s patches proliferation reported Result Safe secreted cytokine serum SIgA significantly increased stimulated Vaccine viral disease virus [DOI] 10.1186/s12917-018-1568-z PMC 바로가기 [Article Type] Research Article
Evolution via recombination: Cell-to-cell contact facilitates larger recombination events in Streptococcus pneumoniae재조합을 통한 진화: 세포 간 접촉은 Streptococcus pneumoniae에서 더 큰 재조합 사건을 촉진합니다Research Article Published on 2018-06-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] adaptation added arising Bacteria Bacterial Cell cells Cluster co-culture competent conditions Contact Culture cultures DNA Donor events Evolution facilitate gene transfer genetic transformation Genome genomes Homologous recombination horizontal gene Horizontal gene transfer Human involved Laboratory less mapped Millipore mixed cultures nasopharynx occur organism parent pathogen pneumococcal pneumococci pneumoniae purified recombinant recombinants Recombination recombination event Sequencing Sex sexual reproduction significantly significantly increased singular SNP SNPs strain Strains Streptococcus pneumoniae thought traits transfer transferred undergo WGS while whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1007410 PMC 바로가기 [Article Type] Research Article
Chaperna-Mediated Assembly of Ferritin-Based Middle East Respiratory Syndrome-Coronavirus NanoparticlesImmunology Published on 2018-05-172022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] affected aggregation Antigen assembly Bacterial binding cellular receptor chaperone Concentration conformations contributed Control defined domain effective Escherichia coli expressed expression favor ferritin fused hDPP4 hosts immunization immunologically in silico in vitro Interaction kinetic lack linker Lysyl-tRNA synthetase MERS-CoV MERS-CoV RBD Microscopy Middle East Middle East respiratory syndrome Coronavirus molecular monomer monomeric Mutation nanoparticle pathway platform presenting proteolytic RBD Receptor-binding domain recombinant vaccine reducing respiratory RNA RNA-interacting domain of human LysRS robust scattering sera serological significantly increased stability Structure structures subsequent Vaccine viral infections Virus-like particle [DOI] 10.3389/fimmu.2018.01093 PMC 바로가기 [Article Type] Immunology
Ultrasensitive Detection of RNA and DNA Viruses Simultaneously Using Duplex UNDP-PCR AssayResearch Article Published on 2015-11-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] added assays characterized coated with complex detect detection detection rate develop DNA DNA and RNA DNA virus DTT exhibiting Gold nanoparticle Infection Intensive lysis buffer magnetic bead mixed infection nucleic acid PCR assay positive probe purification released reproducibility reverse transcription RNA RNA virus selected sensitivity serum serum sample significantly increased specificity TGEV virus viruses [DOI] 10.1371/journal.pone.0141545 PMC 바로가기 [Article Type] Research Article
Alterations in Nerve-Evoked Bladder Contractions in a Coronavirus-Induced Mouse Model of Multiple SclerosisResearch Article Published on 2014-10-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] agonist alteration ATP Bethanechol bladder bladder dysfunction bladder strips blocked cause changes in CNS Combination contractile contraction controls Demyelination disease EFS help male mice Model mouse mucosa Multiple multiple sclerosis muscarinic neurodegenerative not significantly different pathologic pathological change performed physiological receptor receptors reduced removal respond restored Result resulting sclerosis significantly significantly increased Symptom tension underlie urgency urinary frequency Urinary tract [DOI] 10.1371/journal.pone.0109314 PMC 바로가기 [Article Type] Research Article