Psychosocial and clinical effects of the COVID-19 pandemic in patients with childhood rheumatic diseases and their parentsObservational Study Published on 2021-03-012022-10-05 Journal: Rheumatology International [Category] SARS, 임상, [키워드] adolescents age age and gender Anxiety Child childhood children Clinical effect clinician conducted control group COVID-19 COVID-19 pandemic cross-sectional design Depression depression score disease Disease diagnosis Diseases evaluate groups healthy healthy controls increase inventory no difference outbreak pandemic parent parental parents Patient positively correlated Psychiatric psychological symptom Psychosocial questionnaire rheumatic disease Rheumatic diseases rheumatological risk of COVID-19 scale Symptom Treatment variable was used [DOI] 10.1007/s00296-021-04790-x PMC 바로가기 [Article Type] Observational Study
Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical diseaseCOVID-19 백신이 임상 질병을 악화시킬 위험이 있는 백신 시험 대상자에 대한 사전 동의 공개Article Published on 2021-03-012022-09-12 Journal: International journal of clinical practice [Category] MERS, SARS, 진단, [키워드] ADE Antibody-dependent enhancement approach approval approved circulating clinical clinical disease clinical evidence clinical trial clinician composed coronavirus COVID-19 COVID-19 disease COVID-19 vaccine COVID-19 vaccine trial Critical determine disease DNA elicit form identify Informed consent MERS Neutralising Antibodies neutralising antibody occur Patient Protein protocol recipient recruited Research Result risk risk of COVID-19 RNA RSV severe disease subject Trial trial protocol trials unlikely Vaccine vaccine trial viral spike Viral vector virus worsening [DOI] 10.1111/ijcp.13795 PMC 바로가기 [Article Type] Article
Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: Implication of herb-drug interactions in COVID-19 pharmacotherapyQingfei Paidu 달인에 의한 약물 대사 효소 억제: COVID-19 약물 요법에서 허브-약물 상호 작용의 의미Article Published on 2021-03-012022-08-31 Journal: Food and chemical toxicology : an international jo [Category] SARS, 치료제, [키워드] AUC caused China Chinese clinical settings clinically clinician combating Combination concomitant use Corona COVID-19 COVID-19 treatment CYP3A substrate-drugs cytochrome P450 Cytochrome P450 enzymes Cytochrome P450 enzymes (CYPs/P450s) demonstrated Effect enzyme half-life Health Herb Herb-drug interactions (HDIs) in vivo inactivated inhibited inhibition inhibitory Interaction interactions Lopinavir medication modulated NADPH P450s pharmacokinetic pharmacokinetics Qingfei Paidu decoction (QPD). RATs risk significantly Spread the patient Treatment Trigger Virus Disease [DOI] 10.1016/j.fct.2021.111998 PMC 바로가기 [Article Type] Article
Combination of Hydroxychloroquine Plus Azithromycin As Potential Treatment for COVID-19 Patients: Safety Profile, Drug Interactions, and Management of ToxicityCOVID-19 환자를 위한 잠재적 치료제로서 하이드록시클로로퀸과 아지트로마이신의 조합: 안전성 프로파일, 약물 상호작용 및 독성 관리Review Published on 2021-03-012022-09-10 Journal: Microbial Drug Resistance [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 authorization Azithromycin caused clinical trial clinician Combination contagious contagious disease contributing to coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients disease drug Drug–drug interactions early treatment effective Efficacy Evidence Hydroxychloroquine identify Infection information Potential Prevent profile rationale reported respiratory Safe Safety severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 therapeutic strategy Toxicity treat Treatment [DOI] 10.1089/mdr.2020.0232 PMC 바로가기 [Article Type] Review
Clinical description of the broad range of neurological presentations of COVID-19: A retrospective case seriesCOVID-19의 광범위한 신경학적 표현에 대한 임상 설명: 회고적 사례 시리즈Article Published on 2021-03-012022-09-11 Journal: Revue neurologique [Category] SARS, 치료기술, [키워드] Admission Amyotrophic lateral sclerosis Antibody detection Atypical average broad spectrum Case series case sery Central nervous system circulating clinical clinician CNS collected COVID-19 diagnosed Diagnosis diagnosis of COVID-19 diagnosis of SARS-CoV-2 Diaphragmatic ultrasonography disorder Encephalitis Encephalopathy event Guillain-barrè syndrome Infection Isolation Lateral Lateral Sclerosis Mask Masks medical record medical records Nasopharyngeal swab nasopharyngeal swabs Nerve conduction neurological Neurological disorder Neurological disorders Nosocomial infections occur Paris Patient Phrenic nerve Phrenic nerve conduction preventive measure preventive measures pulmonary Pulmonary function tests retrospective RT-PCR SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection serum IgG serum IgG antibodies stroke syndrome [DOI] 10.1016/j.neurol.2021.01.004 PMC 바로가기 [Article Type] Article
Medical vulnerability of individuals with Down syndrome to severe COVID-19–data from the Trisomy 21 Research Society and the UK ISARIC4C surveyResearch article Published on 2021-03-012022-10-05 Journal: EClinicalMedicine [Category] 유전자 메커니즘, [키워드] Action addition age analysed Clinical course clinician collected Complication conditions congenital heart defect cough COVID-19 COVID-19 mortality COVID-19 patient disability Down syndrome Factor Fever finding foundation funding General population group Hospitalization hospitalized COVID-19 patient immune dysfunction individual initiative Intellectual International ISARIC4C Jerome leading less Medical vulnerability Mortality nausea Pain Patient patients with COVID-19 Premature rapid increase risk risk factor severe disease course Shortness of breath significantly higher Society symptoms of COVID-19 trisomy 21 vomiting [DOI] 10.1016/j.eclinm.2021.100769 [Article Type] Research article
Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives메신저 RNA 백신의 나노입자 매개 세포질 전달: 과제 및 미래 전망Review Published on 2021-03-012022-08-31 Journal: Pharmaceutical research [Category] 치료제, [키워드] Cell challenge clinician COVID-19 pandemic cytoplasmic delivery endosomal escape faster followed by Future help immune response induce Intracellular intracellular delivery messenger Messenger RNA mRNA mRNA vaccine mRNA vaccines nanomedicines outlined Perspective physicochemical property profiles provide ribosome ribosomes RNA target Vaccine Vaccines [DOI] 10.1007/s11095-021-03015-x PMC 바로가기 [Article Type] Review
Emerging Immunotherapies against Novel Molecular Targets in Breast CancerReview Published on 2021-02-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] administration antibody Antigen approach bispecific antibodies Breast Breast cancer Cancer CAR CAR-T Cell chimeric clinician COVID-19 vaccine expression profiles form generate highlight Immune checkpoints Immunotherapy improvement in vitro in vivo marker molecular target mRNA vaccine novel precision therapy receptor Research target therapeutic therapy TNBC Treatment triple-negative breast cancer tumor marker tumor specific/associated antigens [DOI] 10.3390/ijms22052433 PMC 바로가기 [Article Type] Review
Proposals for person‐centred care in the COVID‐19 era. Delphi studyOriginal Research Paper Published on 2021-02-272022-11-01 Journal: Health Expectations : An International Journal of Public Participation in Health Care and Health Policy [Category] COVID-19, MERS, SARS, [키워드] approach baseline Care clinician Consensus COVID‐19 criteria delivery of health care DelPhi dimension dimensions Health Health personnel Health Service identify implementation integrated measure Metrics nurse‐patient relations objective participant Participants participated Patient Patient participation patient‐centred care patients performed physician‐patient relations platform Primary Health Care professional professionals Public public health questionnaire reached Result setting spanish health system was used [DOI] 10.1111/hex.13218 PMC 바로가기 [Article Type] Original Research Paper
Content Analysis and Characterization of Medical Tweets During the Early Covid-19 PandemicEmergency Medicine Published on 2021-02-272022-10-31 Journal: Cureus [Category] COVID-19, [키워드] access Analysis analyzed characterization clinician Community content contributed COVID-19 education emotional English Free free open access medical education highlight impacted information Knowledge translation media medical education novel coronavirus disease objective pandemic participant potential benefit profile provide provided public health Randomly Research resource resources Result searched selected setting social media was performed [DOI] 10.7759/cureus.13594 PMC 바로가기 [Article Type] Emergency Medicine