Phospholipase D Facilitates Efficient Entry of Influenza Virus, Allowing Escape from Innate Immune Inhibition *Article Published on 2014-09-122023-06-23 Journal: The Journal of Biological Chemistry [Category] 신종인플루엔자, [키워드] antiviral agent Cell signaling Enzyme inhibitor Influenza virus inhibitors Phospholipase D phospholipid [DOI] 10.1074/jbc.M114.558817 PMC 바로가기
Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including AlisporivirArticle Published on 2014-02-222022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] alisporivir ALV, Alisporivir Caco-2 cell Cell culture cellular Concentration coronavirus Coronavirus replication CoV CoV infection CoV replication CsA/CsD, cyclosporine A/D cyclophilin cyclophilin A Cyclosporine/FK506-non-immunosuppressive derivatives CypA/B, cyclophilin A/B derivative EC50, 50% effective inhibitory concentration effective drug FK506 FKBP FKBP, FK506-binding protein growth HCoV-229E HCoV-NL63 Host Human human coronavirus Infection inhibit inhibited Inhibition of viral replication inhibitors magnitude New NIM811 NL63 PPIase, peptidyl prolyl cis/trans isomerase Prevent qPCR analysis Replication required SARS-CoV shown therapeutic approaches therapy virus replication Weber [DOI] 10.1016/j.virusres.2014.02.010 PMC 바로가기 [Article Type] Article
Bifunctional thiosialosides inhibit influenza virusArticle Published on 2014-01-152023-06-24 Journal: Bioorganic & medicinal chemistry letters [Category] 신종인플루엔자, [키워드] Bifunctional Glycoconjugates Influenza virus inhibitors Sialic acid. [DOI] 10.1016/j.bmcl.2013.11.077 PMC 바로가기
A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoVMethodology Published on 2013-08-262022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] acute respiratory syndrome Antisera antiviral therapeutics backbone BSL-3 can be used cause Cell coronavirus demonstrated detect Dipeptidyl peptidase-4 disease domain DPP4 effective vaccine entry inhibitors evaluate exhibited expressing full-length fused highly pathogenic HIV Human serum albumin IgG Infection inhibit inhibitor inhibitors luciferase-expressing HIV-1 MERS-CoV MERS-CoV entry MERS-CoV pseudovirus mice Middle East Neutralizing antibodies neutralizing antibody Neutralizing antibody response Novel human coronavirus produced Protein pseudovirus RBD receptor residue respiratory syndrome coronavirus Result Safe significantly Spike protein variety viral entry [DOI] 10.1186/1743-422X-10-266 PMC 바로가기 [Article Type] Methodology
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6 , a Gene Identified through Mining the DPH1 – DPH5 Interaction Network효모에서 디프타마이드 생합성의 아미드화 단계에는 DPH1 - DPH5 상호작용 네트워크 마이닝을 통해 확인된 유전자인 DPH6이 필요합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy adenine adenine nucleotide ADP Affect agent amidase Amino acid approach association ATP Author bind Biosynthesis biosynthetic biosynthetic pathway candidate candidate gene Cell cell growth characterized check Complete completion component components Corynebacterium diphtheriae defined Diphthamide dissociation domain DPH1 Dph5 Dph6 Dph7 eEF2 elongation factor embryogenesis enzyme evade expected failure Final form found generate Genes Genetic genetic interaction genomic growth histidine Identified identify inactivation indicated inhibitor inhibitors initial Interaction involved Like maintain mass spectrometry mice molecular mutant name network nucleotide observation pathogen pathway produced promote Protein protein synthesis Proteins Regulatory required residue response Saccharomyces cerevisiae step target trait translation translational upregulated [DOI] 10.1371/journal.pgen.1003334 PMC 바로가기 [Article Type] Research Article
SARS-CoV 9b Protein Diffuses into Nucleus, Undergoes Active Crm1 Mediated Nucleocytoplasmic Export and Triggers Apoptosis When Retained in the NucleusResearch Article Published on 2011-05-272022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] absence Affect Amino acid Apoptosis caspase-3 Cell cellular Critical death Degradation diffuse elevated export found host cell independent induce influence inhibitors interact Interaction Mediated NES NLS nuclear nuclear localization signal nucleus principal Protein SARS-CoV shown transiently transfected Transport Trigger [DOI] 10.1371/journal.pone.0019436 PMC 바로가기 [Article Type] Research Article
Profiling of Substrate Specificity of SARS-CoV 3CL proResearch Article Published on 2010-10-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 3CL pro autocleavage charged residue cleavage Coronaviral correlated demonstrated detected different electrostatic interaction energy transfer finding fluorescent protein found Gln hydrophobic hydrophobic residue in vitro Infection inhibitors Mutagenesis polyprotein Profiling protease required residue residues SARS-CoV sequence solvent specificity Structural properties substitutions substrate variant wild-type β-sheet [DOI] 10.1371/journal.pone.0013197 PMC 바로가기 [Article Type] Research Article
Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral DrugsResearch Published on 2004-04-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome agents Antiviral Antiviral agents antiviral drug antiviral drugs antivirals approved caused clinical testing clinically Compound coronavirus Coronavirus infection Culture cultured cell Cytopathic effect drug effective in vitro Infectious disease inhibition inhibitors interferon interferons investigated leukocyte neuraminidase inhibitors nucleoside analogs protease inhibitors SARS virus SARS-CoV SARS-CoV infection severe Severe acute respiratory syndrome Subtypes Support transcriptase treat Treatment was used [DOI] 10.3201/eid1004.030458 PMC 바로가기 [Article Type] Research