The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase
Structure and Assembly
[키워드] activity
acute respiratory syndrome
addition
ADP-ribose
ADP-ribosylation
affinity
animal model
Antiviral
approved
bind
binding
Biochemistry
caused
complex
Compound
conserved
coronavirus
CoV
CoV infection
COVID-19
Critical
death
demonstrated
domain
ELISAs
enzyme
enzyme activity
enzyme-linked immunosorbent assay
functions
host response
hydrolysis
increasingly
Mac1
macrodomain
MAR
MERS-CoV
Middle East
Modification
mono-ADP-ribose
nonstructural protein 3
Nsp3
Pathogenesis
poly-ADP-ribose
potential therapeutic target
potential therapy
Protein
Proteins
reagent
regulate
respiratory syndrome coronavirus
SARS-CoV
SARS-CoV-2
SARS-related CoV
target proteins
the SARS-CoV-2
therapeutic strategy
therapeutic target
unique
viral infection
viral infections
virulence
worldwide pandemic
[DOI] 10.1128/JVI.01969-20 PMC 바로가기 [Article Type] Structure and Assembly
[DOI] 10.1128/JVI.01969-20 PMC 바로가기 [Article Type] Structure and Assembly